551 KiB
Executable File
551 KiB
Executable File
Gene,Alteration,Oncogenic,Mutation_Effect,Citations,GRCh37_Isoform,GRCh37_RefSeq,Is_Oncogene,Is_Tumor_Suppressor_Gene CDK6,A197T,Likely Neutral,Loss-of-function,4,ENST00000265734,NM_001145306.1,Yes,No MSH2,D603G,Inconclusive,Inconclusive,4,ENST00000233146,NM_000251.2,No,Yes MSH2,S860L,Likely Neutral,Likely Neutral,4,ENST00000233146,NM_000251.2,No,Yes MSH2,G322D,Inconclusive,Inconclusive,4,ENST00000233146,NM_000251.2,No,Yes MSH2,D603N,Likely Oncogenic,Loss-of-function,4,ENST00000233146,NM_000251.2,No,Yes MSH2,A272V,Likely Neutral,Likely Neutral,4,ENST00000233146,NM_000251.2,No,Yes MSH2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000233146,NM_000251.2,No,Yes MSH2,A636P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000233146,NM_000251.2,No,Yes MSH2,L390F,Inconclusive,Inconclusive,4,ENST00000233146,NM_000251.2,No,Yes MSH2,C697R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000233146,NM_000251.2,No,Yes MSH2,L595R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000233146,NM_000251.2,No,Yes MSH2,G751R,Likely Oncogenic,Loss-of-function,4,ENST00000233146,NM_000251.2,No,Yes MSH2,L310R,Inconclusive,Inconclusive,4,ENST00000233146,NM_000251.2,No,Yes MSH2,F694S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000233146,NM_000251.2,No,Yes MSH2,H639Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000233146,NM_000251.2,No,Yes MSH2,A305T,Likely Neutral,Likely Neutral,4,ENST00000233146,NM_000251.2,No,Yes MSH2,G674R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000233146,NM_000251.2,No,Yes MSH2,P349R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000233146,NM_000251.2,No,Yes MSH2,S723F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000233146,NM_000251.2,No,Yes MSH2,G162R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000233146,NM_000251.2,No,Yes CTNNB1,K335T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,I35S,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,S23R,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,T41I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,S37F,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,S33Y,Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,S33A,Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,G34E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,S33C,Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,H36P,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,D32A,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,S45del,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,W383S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,G34R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,S37Y,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,S37A,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,K335I,Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,G34V,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,D32V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,P44A,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,T41A,Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,N387K,Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,W383G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,D32N,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,S37C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,W383R,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,S33P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,D32H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,D32G,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,D32Y,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,H36Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,S33F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,S45P,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,S45F,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,S45Y,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,G34A,Likely Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No CTNNB1,S45A,Oncogenic,Gain-of-function,4,ENST00000349496,NM_001904.3,Yes,No BBC3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000449228,NM_001127240.2,No,Yes RAD51D,S207L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000345365,NM_002878.3,No,Yes RAD51D,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000345365,NM_002878.3,No,Yes RAD51D,S257_R259delinsK,Resistance,Inconclusive,4,ENST00000345365,NM_002878.3,No,Yes FES,L145P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000328850,NM_002005,Yes,No FES,L334P,Likely Neutral,Likely Neutral,4,ENST00000328850,NM_002005,Yes,No EP300,D1399N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263253,NM_001429.3,No,Yes EP300,P1502L,Likely Oncogenic,Loss-of-function,4,ENST00000263253,NM_001429.3,No,Yes EP300,R1627W,Inconclusive,Inconclusive,4,ENST00000263253,NM_001429.3,No,Yes EP300,D1399Y,Likely Oncogenic,Loss-of-function,4,ENST00000263253,NM_001429.3,No,Yes EP300,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263253,NM_001429.3,No,Yes EP300,Y1414C,Likely Oncogenic,Loss-of-function,4,ENST00000263253,NM_001429.3,No,Yes EP300,R1627Q,Inconclusive,Inconclusive,4,ENST00000263253,NM_001429.3,No,Yes EP300,H1451L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263253,NM_001429.3,No,Yes SOCS1,P198S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000332029,NM_003745.1,No,Yes SOCS1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000332029,NM_003745.1,No,Yes PDGFRA,V469A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,H845_N848delinsP,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,C456_N468del,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,I562M,Likely Neutral,Neutral,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,T674I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,R841K,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,P577S,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,H845Y,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,W349C,Likely Neutral,Likely Loss-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,H570R,Likely Neutral,Likely Neutral,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,Exon 18 missense mutations,Likely Oncogenic,Likely Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,R560_V561insER,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,E311_K312del,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,D842_M844del,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,Y375_K455del,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,F808L,Likely Neutral,Loss-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,D842Y,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,Y555C,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,V658A,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,R748G,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,N848K,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,D846Y,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,V561D,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,P130S,Likely Neutral,Likely Neutral,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,Y288C,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,L507P,Likely Neutral,Likely Neutral,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,V536E,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,C456_R481del,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,311_848ins,Likely Oncogenic,Likely Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,D568N,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,D842V,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,Y849S,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,Y849C,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,D842_H845insV,Likely Oncogenic,Likely Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,H650Q,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,N659S,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,V561A,Oncogenic,Likely Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,311_848del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,W559_R560del,Inconclusive,Inconclusive,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,I834V,Likely Neutral,Likely Neutral,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,D1071N,Likely Neutral,Likely Neutral,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,N659K,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,V561_I562insER,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,D842_I843delinsIM,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,I843del,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,K830R,Likely Neutral,Likely Neutral,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,D842I,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,S566_E571delinsR,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,I843_D846del,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,D842_H845del,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,C450_K451insMIEWMI,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,N870S,Likely Neutral,Likely Neutral,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,S584L,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,G853D,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,V544_L545insAVLVLLVIVIISLI,Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,A633T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,Q579R,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,S478P,Likely Neutral,Likely Neutral,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,E996K,Likely Neutral,Likely Neutral,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,Exon 18 deletions,Likely Oncogenic,Likely Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,G829R,Likely Neutral,Neutral,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,Exon 18 insertions,Likely Oncogenic,Likely Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,A633V,Likely Neutral,Neutral,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,R481G,Likely Neutral,Likely Neutral,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,N659R,Likely Oncogenic,Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No PDGFRA,N659Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000257290,NM_006206.4,Yes,No U2AF1,S34Y,Oncogenic,Likely Gain-of-function,4,ENST00000291552,NM_006758.2,Yes,No U2AF1,S34F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000291552,NM_006758.2,Yes,No U2AF1,R156H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000291552,NM_006758.2,Yes,No U2AF1,E159_M160insYE,Likely Oncogenic,Likely Loss-of-function,4,ENST00000291552,NM_006758.2,Yes,No U2AF1,I24T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000291552,NM_006758.2,Yes,No U2AF1,R156Q,Likely Neutral,Likely Neutral,4,ENST00000291552,NM_006758.2,Yes,No U2AF1,Q157R,Oncogenic,Likely Gain-of-function,4,ENST00000291552,NM_006758.2,Yes,No U2AF1,I24V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000291552,NM_006758.2,Yes,No U2AF1,Q157P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000291552,NM_006758.2,Yes,No ARID4A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000355431,NM_002892.3,No,Yes SRC,Q531*,Likely Oncogenic,Gain-of-function,4,ENST00000358208,NM_198291.2,Yes,No ATRIP,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320211,NM_130384,No,Yes BAP1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000460680,NM_004656.3,No,Yes BAP1,G178V,Likely Oncogenic,Loss-of-function,4,ENST00000460680,NM_004656.3,No,Yes BAP1,A95D,Likely Oncogenic,Loss-of-function,4,ENST00000460680,NM_004656.3,No,Yes BAP1,C91S,Oncogenic,Likely Loss-of-function,4,ENST00000460680,NM_004656.3,No,Yes BAP1,E685V,Likely Oncogenic,Loss-of-function,4,ENST00000460680,NM_004656.3,No,Yes BAP1,F170I,Likely Oncogenic,Loss-of-function,4,ENST00000460680,NM_004656.3,No,Yes BAP1,F81V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000460680,NM_004656.3,No,Yes BAP1,C91A,Likely Oncogenic,Loss-of-function,4,ENST00000460680,NM_004656.3,No,Yes BAP1,R146K,Inconclusive,Inconclusive,4,ENST00000460680,NM_004656.3,No,Yes BAP1,I47F,Likely Oncogenic,Loss-of-function,4,ENST00000460680,NM_004656.3,No,Yes FANCC,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000289081,NM_000136.2,No,Yes FGFR4,S342F,Likely Neutral,Likely Neutral,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,R635S,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,D127H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,N535K,Oncogenic,Gain-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,G176C,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,V550E,Oncogenic,Gain-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,R134G,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,Y367C,Oncogenic,Gain-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,R59W,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,C271*,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,R321W,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,A749V,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,A484V,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,R434Q,Likely Neutral,Likely Neutral,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,R707W,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,R464W,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,R411fs*81,Likely Neutral,Likely Neutral,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,R203C,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,C172G,Inconclusive,Inconclusive,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,G687fs*35,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,V550M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,R154H,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,E681K,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,V550L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,R80W,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,R493Q,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,E128K,Likely Neutral,Likely Loss-of-function,4,ENST00000292408,NM_213647.1,Yes,No FGFR4,V548M,Likely Neutral,Likely Neutral,4,ENST00000292408,NM_213647.1,Yes,No TRIP13,R354*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000166345,NM_004237.3,Yes,Yes TGFBR1,C41Y,Likely Oncogenic,Loss-of-function,4,ENST00000374994,NM_004612.2,No,Yes TGFBR1,TGFBR1*6A,Likely Oncogenic,Loss-of-function,4,ENST00000374994,NM_004612.2,No,Yes TGFBR1,P83L,Likely Oncogenic,Loss-of-function,4,ENST00000374994,NM_004612.2,No,Yes TGFBR1,G52R,Likely Oncogenic,Loss-of-function,4,ENST00000374994,NM_004612.2,No,Yes TGFBR1,S241L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000374994,NM_004612.2,No,Yes TGFBR1,S387Y,Likely Oncogenic,Loss-of-function,4,ENST00000374994,NM_004612.2,No,Yes TGFBR1,N45S,Likely Oncogenic,Loss-of-function,4,ENST00000374994,NM_004612.2,No,Yes TGFBR1,R487Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000374994,NM_004612.2,No,Yes TGFBR1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000374994,NM_004612.2,No,Yes TMEM127,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000258439,NM_001193304.2,No,Yes MAL2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000276681,NM_052886.2,No,Yes FOXF1,S2F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262426,NM_001451.2,Yes,Yes ZFHX3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000268489,NM_006885.3,No,Yes ECSIT,T419C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000270517,NM_016581,Yes,No ECSIT,V140A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000270517,NM_016581,Yes,No EGFR,vII,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V834L,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G983R,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,vIII,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L861Q,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,R108K,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S811F,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E746_T751insIP,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,R831H,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G588S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G719C,Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,K745M,Likely Neutral,Loss-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E884K,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,D761N,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V851A,Likely Neutral,Loss-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,H773_V774insNPH,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L747_T751del,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V769M,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E746_T751delinsA,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L833V,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A289I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,I744M,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E114K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S720F,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,C620Y,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S229C,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,D770_N771insGL,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G796D,Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,H773Y,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,T363I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A859T,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,R776C,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,Kinase Domain Duplication,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E746_S752delinsV,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,C-terminal domain,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,D770_N771insSVD,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G428D,Likely Neutral,Loss-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E865K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,P772R,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E746_S752delinsA,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S116F,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,H773L,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S784F,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,K467T,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,T854I,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,K745_E746insVPVAIK,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G796R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,K860I,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,Exon 19 deletions,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,D770_N771insGF,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S768_D770dup,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,H304Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,R841K,Likely Neutral,Likely Loss-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,D587H,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,P772_V774dup,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E709A,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G735S,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V689M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V786M,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L704N,Likely Neutral,Loss-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A763_Y764insFQEA,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,I853T,Likely Neutral,Loss-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L833F,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L792F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,M277E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E746_S752delinsI,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,T785A,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,T363N,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,R776G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,D256Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,R669Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,C797G,Resistance,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,T854S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,Exon 19 insertions,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L861R,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,K745_A750del,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A611T,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,vV,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G810S,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S720P,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,R252P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A763insLQEA,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,R108G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E709Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S464L,Likely Neutral,Likely Loss-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,D770_N771insNPG,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L38V,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V769L,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E746_T751delinsL,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,P772_H773dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,D770_P772dup,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,H773R,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,R98Q,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L718Q,Resistance,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E746_T751delinsVA,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L747_T751delinsP,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V769_D770insGVV,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E709V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,T854A,Resistance,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,P589L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E931G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S492R,Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,D1009N,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,Exon 20 insertions,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V769_D770insASV,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,N771_H773dup,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,D770_N771insY,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,W731L,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,D761Y,Resistance,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L792H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,M178I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V292L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,R776H,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A750_E758del,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L747V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,N771_P772insH,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,P772_H773insYNP,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L747_P753del,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E709_T710delinsD,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E746_A750del,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A289D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A871G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A767_V769dup,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V292M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E330K,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,H835L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A750P,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L838P,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L858Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,I941R,Likely Neutral,Likely Loss-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L844V,Resistance,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,C797Y,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E709G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L858R,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,P772_H773insTPNP,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,P596L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S198R,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,P272L,Likely Neutral,Likely Loss-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V592I,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L747_A750del,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,N826S,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V843I,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V148M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L747_E749del,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,C628Y,Likely Neutral,Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,K754E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E746_A750delinsQ,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E866K,Likely Neutral,Loss-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A767_S768insASV,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G719S,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,N528D,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L62R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G719D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,I491M,Likely Oncogenic,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S645C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V774_C775insPR,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S768I,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G863D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,D191N,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V159E,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L747_A750delinsP,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,H870R,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L814P,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,D770delinsGY,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G796S,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E734Q,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,H47Y,Likely Neutral,Likely Loss-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S220P,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S768_V769insSVD,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G465R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,T263P,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,H773insLGNP,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,Q105H,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E709K,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,Y801H,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,I744_K745delinsKIPVAI,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,T1041A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,P596S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,T725M,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A755G,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L747_K754delinsATSPE,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,P373Q,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V774L,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L718V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A750_E758delinsP,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A864T,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,R324L,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E282K,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L747P,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V774M,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G719A,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L688P,Likely Neutral,Likely Loss-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,Q181H,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G779F,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G598A,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,Q787R,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,R222C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,P848L,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V774_C775insAV,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E45Q,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,R521K,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E804G,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,F712L,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,H773_V774insH,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,C797S,Resistance,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G857E,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S921R,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A767T,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,D770_N771insG,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S768_V769insVAS,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,D770_N771insVDSVDNP,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G724S,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V834I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,T790M,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A767_V769del,Inconclusive,Inconclusive,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A289T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,S306L,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,R252C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,K754_I759del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L838V,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,E868G,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L747S,Likely Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L747_P753delinsS,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L747_S752del,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A508V,Likely Neutral,Likely Neutral,4,ENST00000275493,NM_005228.3,Yes,No EGFR,Y764_D770dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,N771_P772insHH,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,A289V,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,H773dup,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,G598V,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,T354M,Likely Neutral,Likely Loss-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,D770_N771insD,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,V742A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No MSH3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000265081,NM_002439.4,No,Yes MSH3,K383Rfs*32,Likely Oncogenic,Likely Loss-of-function,4,ENST00000265081,NM_002439.4,No,Yes EIF1AX,N4D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379607,NM_001412.3,No,No EIF1AX,G15V,Likely Neutral,Likely Neutral,4,ENST00000379607,NM_001412.3,No,No EIF1AX,G15D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379607,NM_001412.3,No,No EIF1AX,R13P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379607,NM_001412.3,No,No EIF1AX,G8R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000379607,NM_001412.3,No,No EIF1AX,G9R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000379607,NM_001412.3,No,No EIF1AX,K3E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379607,NM_001412.3,No,No EIF1AX,G6D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000379607,NM_001412.3,No,No EIF1AX,A113_splice,Likely Oncogenic,Likely Gain-of-function,4,ENST00000379607,NM_001412.3,No,No MTOR,E1799K,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,A8S,Likely Neutral,Likely Neutral,4,ENST00000361445,NM_004958.3,Yes,No MTOR,T2232I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,K1452N,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,S2215T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,A1428T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,C1483F,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,A1459P,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,A41T,Likely Neutral,Likely Neutral,4,ENST00000361445,NM_004958.3,Yes,No MTOR,V2006I,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,P2476L,Likely Neutral,Likely Neutral,4,ENST00000361445,NM_004958.3,Yes,No MTOR,F1888I,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,S2215P,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,S2231W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,F1888V,Inconclusive,Inconclusive,4,ENST00000361445,NM_004958.3,Yes,No MTOR,P2273S,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,I2500M,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,A2226S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,R2505Q,Likely Neutral,Likely Neutral,4,ENST00000361445,NM_004958.3,Yes,No MTOR,Y1450D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,R2152C,Likely Neutral,Likely Neutral,4,ENST00000361445,NM_004958.3,Yes,No MTOR,C1483R,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,M2327I,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,A41S,Likely Neutral,Likely Neutral,4,ENST00000361445,NM_004958.3,Yes,No MTOR,W1456R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,F2108L,Likely Neutral,Likely Neutral,4,ENST00000361445,NM_004958.3,Yes,No MTOR,L2216P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,T1977R,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,E2014K,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,D2512H,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,L2230V,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,R2505*,Likely Neutral,Likely Neutral,4,ENST00000361445,NM_004958.3,Yes,No MTOR,A41P,Likely Neutral,Likely Neutral,4,ENST00000361445,NM_004958.3,Yes,No MTOR,S2215F,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,S2215Y,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,L2427Q,Inconclusive,Inconclusive,4,ENST00000361445,NM_004958.3,Yes,No MTOR,Q2223K,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,A2210P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,E2419K,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,E2288K,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,A2034V,Likely Neutral,Likely Neutral,4,ENST00000361445,NM_004958.3,Yes,No MTOR,L2431P,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,L2427P,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,I2500F,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,A1519T,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,T1977I,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,I1973F,Inconclusive,Inconclusive,4,ENST00000361445,NM_004958.3,Yes,No MTOR,Y1463S,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,L2427R,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,L2220F,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,T1977S,Likely Neutral,Likely Neutral,4,ENST00000361445,NM_004958.3,Yes,No MTOR,V2006F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,F1888L,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,D2512G,Likely Neutral,Likely Neutral,4,ENST00000361445,NM_004958.3,Yes,No MTOR,L1460P,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,L1433S,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,D2512Y,Likely Neutral,Likely Neutral,4,ENST00000361445,NM_004958.3,Yes,No MTOR,L2172M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,R2505P,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,C1483W,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,R2430M,Likely Neutral,Likely Neutral,4,ENST00000361445,NM_004958.3,Yes,No MTOR,L2209V,Likely Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,T1977K,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,R2217W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,C1483Y,Oncogenic,Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No MTOR,V2006L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361445,NM_004958.3,Yes,No DAXX,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000374542,NM_001141970.1,No,Yes HRAS,A59T,Oncogenic,Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G15_K16insGVG,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12D,Oncogenic,Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,Q61H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G13D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,A11_G12insVN,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,Q61K,Oncogenic,Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,A59G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,K117N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12S,Oncogenic,Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,A11_G12insPGSG,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,Y64A,Inconclusive,Inconclusive,4,ENST00000451590,NM_005343.2,Yes,No HRAS,K117R,Oncogenic,Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,A146V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,Q22K,Inconclusive,Inconclusive,4,ENST00000451590,NM_005343.2,Yes,No HRAS,Q61L,Oncogenic,Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,T58I,Inconclusive,Inconclusive,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G13S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12delG,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12_G13insGAG,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12V,Oncogenic,Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,Q61R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,A146T,Oncogenic,Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,P34R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,F28L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No HRAS,G12Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000451590,NM_005343.2,Yes,No LZTR1,G248R,Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes LZTR1,R810W,Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes LZTR1,R688C,Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes LZTR1,H287Y,Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes LZTR1,R284C,Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes LZTR1,R198G,Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes LZTR1,S247N,Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes LZTR1,S813I,Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes LZTR1,T288I,Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes LZTR1,S122L,Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes LZTR1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes LZTR1,P520L,Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes LZTR1,Y119C,Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes LZTR1,W105R,Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes LZTR1,V456G,Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes LZTR1,R466Q,Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes LZTR1,G404R,Oncogenic,Likely Loss-of-function,4,ENST00000215739,NM_006767.3,No,Yes ERCC2,R631C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,E576K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,G665A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,H659Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,D423N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,G665C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,Y24C,Oncogenic,Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,E606Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,E86Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,L461V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,T46S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,D609E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,Y14C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,Y72C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,R299W,Likely Neutral,Likely Neutral,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,T484M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,R683W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,F568fs,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,M42V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,A717G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,Q758E,Likely Neutral,Likely Neutral,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,P463L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,S746fs,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,G675S,Likely Neutral,Likely Neutral,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,D609G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,D312N,Likely Neutral,Likely Neutral,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,D513Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,E79D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,V536M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,Y209C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,E606G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,R450H,Likely Neutral,Likely Neutral,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,R487W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,S44L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,R592H,Likely Neutral,Likely Neutral,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,G607A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,P463S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,N238S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,S246F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,R601Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,R286W,Likely Neutral,Likely Neutral,4,ENST00000391945,NM_000400.3,No,Yes ERCC2,V242F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000391945,NM_000400.3,No,Yes ATP1A1,E960_A963delinsS,Likely Oncogenic,Likely Loss-of-function,4,ENST00000295598,NM_000701,Yes,Yes ATP1A1,L100_I104del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000295598,NM_000701,Yes,Yes ATP1A1,V332G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000295598,NM_000701,Yes,Yes ATP1A1,L104R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000295598,NM_000701,Yes,Yes ATP1A1,G99R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000295598,NM_000701,Yes,Yes FBXW2,S84C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000608872,NM_012164,No,No FBXW2,D30Y,Likely Neutral,Likely Neutral,4,ENST00000608872,NM_012164,No,No FBXW2,G258W,Likely Neutral,Likely Neutral,4,ENST00000608872,NM_012164,No,No FBXW2,E269K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000608872,NM_012164,No,No DUSP4,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000240100,NM_001394.6,No,Yes FANCA,R1055L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000389301,NM_000135.2,No,Yes FANCA,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000389301,NM_000135.2,No,Yes FANCA,L210R,Likely Oncogenic,Loss-of-function,4,ENST00000389301,NM_000135.2,No,Yes FANCA,R435C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000389301,NM_000135.2,No,Yes FANCA,Y510C,Likely Oncogenic,Loss-of-function,4,ENST00000389301,NM_000135.2,No,Yes FANCA,R1117G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000389301,NM_000135.2,No,Yes FANCA,S858R,Likely Oncogenic,Loss-of-function,4,ENST00000389301,NM_000135.2,No,Yes FANCA,W183A,Likely Oncogenic,Loss-of-function,4,ENST00000389301,NM_000135.2,No,Yes FANCA,S1088F,Likely Oncogenic,Loss-of-function,4,ENST00000389301,NM_000135.2,No,Yes FANCA,L274P,Likely Oncogenic,Loss-of-function,4,ENST00000389301,NM_000135.2,No,Yes FANCA,H492R,Likely Oncogenic,Loss-of-function,4,ENST00000389301,NM_000135.2,No,Yes CD79B,Y197S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000392795,NM_001039933.1,Yes,No CD79B,Y197H,Oncogenic,Gain-of-function,4,ENST00000392795,NM_001039933.1,Yes,No CD79B,E198G,Oncogenic,Gain-of-function,4,ENST00000392795,NM_001039933.1,Yes,No CD79B,Y197N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000392795,NM_001039933.1,Yes,No CD79B,Y197F,Oncogenic,Gain-of-function,4,ENST00000392795,NM_001039933.1,Yes,No CD79B,Y197C,Oncogenic,Gain-of-function,4,ENST00000392795,NM_001039933.1,Yes,No PPP6C,H114Y,Oncogenic,Loss-of-function,4,ENST00000373547,NM_002721.4,No,Yes PPP6C,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373547,NM_002721.4,No,Yes PPP6C,R264C,Likely Oncogenic,Loss-of-function,4,ENST00000373547,NM_002721.4,No,Yes PPP6C,S270L,Likely Oncogenic,Loss-of-function,4,ENST00000373547,NM_002721.4,No,Yes PPP6C,P186S,Likely Oncogenic,Loss-of-function,4,ENST00000373547,NM_002721.4,No,Yes ERRFI1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000377482,NM_018948.3,No,Yes MUTYH,P391L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000372115,NM_001048171.1,No,Yes MUTYH,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000372115,NM_001048171.1,No,Yes MUTYH,R168C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000372115,NM_001048171.1,No,Yes MUTYH,G382D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000372115,NM_001048171.1,No,Yes MUTYH,R95W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000372115,NM_001048171.1,No,Yes MUTYH,R231C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000372115,NM_001048171.1,No,Yes MUTYH,R260Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000372115,NM_001048171.1,No,Yes MUTYH,E466del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000372115,NM_001048171.1,No,Yes MUTYH,Y165C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000372115,NM_001048171.1,No,Yes CBFB,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000412916,NM_022845.2,No,Yes BRIP1,S407G,Likely Neutral,Likely Neutral,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,G690E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,P47A,Oncogenic,Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,D791V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,H587L,Likely Neutral,Likely Neutral,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,E511G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,E636K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,A745T,Likely Neutral,Likely Neutral,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,R777C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,R173C,Inconclusive,Inconclusive,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,R251C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,Q740H,Likely Neutral,Likely Neutral,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,I782V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,Y822H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,R865W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,K797R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,S624L,Inconclusive,Inconclusive,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,M299I,Inconclusive,Inconclusive,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,C832Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,L844I,Likely Neutral,Likely Neutral,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,I691L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,G649S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,A349P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,V676E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,K52R,Oncogenic,Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes BRIP1,R798*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000259008,NM_032043.2,No,Yes POLE,P286S,Likely Oncogenic,Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,L424V,Likely Oncogenic,Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,S459Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,S459F,Likely Oncogenic,Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,V411L,Likely Oncogenic,Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,D368Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,S459del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,F367V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,L424I,Likely Oncogenic,Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,P286R,Likely Oncogenic,Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,P436R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,F367S,Likely Oncogenic,Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,S297F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,V411M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,S297Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,M295R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,M444K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,P286L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,P286H,Likely Oncogenic,Loss-of-function,4,ENST00000320574,NM_006231.2,No,Yes POLE,A456P,Inconclusive,Inconclusive,4,ENST00000320574,NM_006231.2,No,Yes PDGFRB,R987W,Inconclusive,Likely Loss-of-function,4,ENST00000261799,NM_002609.3,Yes,No PDGFRB,V665A,Oncogenic,Loss-of-function,4,ENST00000261799,NM_002609.3,Yes,No PDGFRB,P584R,Oncogenic,Gain-of-function,4,ENST00000261799,NM_002609.3,Yes,No PDGFRB,C843G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000261799,NM_002609.3,Yes,No PDGFRB,P660T,Likely Neutral,Likely Neutral,4,ENST00000261799,NM_002609.3,Yes,No PDGFRB,N666K,Oncogenic,Gain-of-function,4,ENST00000261799,NM_002609.3,Yes,No PDGFRB,R561C,Likely Oncogenic,Gain-of-function,4,ENST00000261799,NM_002609.3,Yes,No PDGFRB,L658P,Likely Neutral,Loss-of-function,4,ENST00000261799,NM_002609.3,Yes,No PDGFRB,E1071W,Likely Neutral,Likely Loss-of-function,4,ENST00000261799,NM_002609.3,Yes,No PDGFRB,N666H,Oncogenic,Gain-of-function,4,ENST00000261799,NM_002609.3,Yes,No PHF6,K235E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000332070,NM_001015877.1,No,Yes PHF6,R274E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000332070,NM_001015877.1,No,Yes PHF6,R274Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000332070,NM_001015877.1,No,Yes PHF6,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000332070,NM_001015877.1,No,Yes ARID4B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264183,NM_001206794.1,No,Yes MYC,P74Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000377970,NM_002467.4,Yes,No MYC,T73N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000377970,NM_002467.4,Yes,No MYC,T73I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000377970,NM_002467.4,Yes,No MYC,T73A,Likely Oncogenic,Gain-of-function,4,ENST00000377970,NM_002467.4,Yes,No MYC,MYC-nick,Inconclusive,Inconclusive,4,ENST00000377970,NM_002467.4,Yes,No AFF4,Y256C,Inconclusive,Inconclusive,4,ENST00000265343,NM_014423,Yes,No NOTCH4,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000375023,NM_004557.3,Yes,Yes PTPRS,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357368,NM_002850.3,No,Yes PTPRD,P1311T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356435,NM_002839.3,No,Yes PTPRD,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356435,NM_002839.3,No,Yes PTPRD,R1088C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356435,NM_002839.3,No,Yes PTPRD,G446E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356435,NM_002839.3,No,Yes PTPRD,V1565I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356435,NM_002839.3,No,Yes TGFBR2,R537P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000295754,NM_003242.5,No,Yes TGFBR2,D379G,Likely Oncogenic,Loss-of-function,4,ENST00000295754,NM_003242.5,No,Yes TGFBR2,E526Q,Likely Oncogenic,Loss-of-function,4,ENST00000295754,NM_003242.5,No,Yes TGFBR2,P525L,Likely Oncogenic,Loss-of-function,4,ENST00000295754,NM_003242.5,No,Yes TGFBR2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000295754,NM_003242.5,No,Yes TGFBR2,V419L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000295754,NM_003242.5,No,Yes CMTR2,K117A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000338099,NM_001099642.1,No,Yes CMTR2,K275A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000338099,NM_001099642.1,No,Yes CMTR2,D235A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000338099,NM_001099642.1,No,Yes ERCC3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000285398,NM_000122.1,No,Yes ERCC3,R109*,Likely Oncogenic,Loss-of-function,4,ENST00000285398,NM_000122.1,No,Yes DDX41,R525H,Inconclusive,Inconclusive,4,ENST00000507955,NM_016222.2,No,Yes PIM1,E135K,Likely Neutral,Likely Neutral,4,ENST00000373509,NM_002648.3,No,No PIM1,P123M,Likely Neutral,Likely Neutral,4,ENST00000373509,NM_002648.3,No,No PIM1,L2V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000373509,NM_002648.3,No,No PIM1,P81S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373509,NM_002648.3,No,No PIM1,E142D,Inconclusive,Inconclusive,4,ENST00000373509,NM_002648.3,No,No PIM1,N82K,Likely Neutral,Likely Loss-of-function,4,ENST00000373509,NM_002648.3,No,No PIM1,E124Q,Inconclusive,Inconclusive,4,ENST00000373509,NM_002648.3,No,No PIM1,H68Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000373509,NM_002648.3,No,No PIM1,S97N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000373509,NM_002648.3,No,No PIM1,Y53H,Inconclusive,Inconclusive,4,ENST00000373509,NM_002648.3,No,No PIM1,L193F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373509,NM_002648.3,No,No CDK4,K22A,Oncogenic,Gain-of-function,4,ENST00000257904,NM_000075.3,Yes,No CDK4,R24C,Oncogenic,Gain-of-function,4,ENST00000257904,NM_000075.3,Yes,No PMAIP1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000316660,NM_021127.2,No,Yes STAT5B,N642H,Oncogenic,Gain-of-function,4,ENST00000293328,NM_012448.3,Yes,No STAT5B,T628S,Likely Oncogenic,Gain-of-function,4,ENST00000293328,NM_012448.3,Yes,No STAT5B,Q706L,Likely Neutral,Likely Neutral,4,ENST00000293328,NM_012448.3,Yes,No CEBPA,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000498907,NM_004364.3,No,Yes PPP2R1A,R258C,Inconclusive,Inconclusive,4,ENST00000322088,NM_014225.5,No,Yes PPP2R1A,S256F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000322088,NM_014225.5,No,Yes PPP2R1A,W257C,Inconclusive,Inconclusive,4,ENST00000322088,NM_014225.5,No,Yes PPP2R1A,P179L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000322088,NM_014225.5,No,Yes PPP2R1A,S256W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000322088,NM_014225.5,No,Yes PPP2R1A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000322088,NM_014225.5,No,Yes PPP2R1A,R183P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000322088,NM_014225.5,No,Yes PPP2R1A,R183W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000322088,NM_014225.5,No,Yes PPP2R1A,R183Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000322088,NM_014225.5,No,Yes PPP2R1A,R258H,Inconclusive,Inconclusive,4,ENST00000322088,NM_014225.5,No,Yes PPP2R1A,W257G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000322088,NM_014225.5,No,Yes PPP2R1A,R182W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000322088,NM_014225.5,No,Yes PPP2R1A,R183G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000322088,NM_014225.5,No,Yes PPP2R1A,P179R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000322088,NM_014225.5,No,Yes PPP2R1A,S256Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000322088,NM_014225.5,No,Yes SAMHD1,D497Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262878,NM_015474.3,No,Yes SAMHD1,A338T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262878,NM_015474.3,No,Yes SAMHD1,R366H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262878,NM_015474.3,No,Yes SAMHD1,V133I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262878,NM_015474.3,No,Yes CTCF,R339W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264010,NM_006565.3,No,Yes CTCF,R377H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264010,NM_006565.3,No,Yes CTCF,P378L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264010,NM_006565.3,No,Yes CTCF,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264010,NM_006565.3,No,Yes CTCF,Y226C,Likely Neutral,Likely Neutral,4,ENST00000264010,NM_006565.3,No,Yes CTCF,H284N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264010,NM_006565.3,No,Yes CTCF,H284P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264010,NM_006565.3,No,Yes CTCF,H284Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264010,NM_006565.3,No,Yes PTCH1,R571W,Likely Neutral,Likely Neutral,4,ENST00000331920,NM_000264.3,No,Yes PTCH1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000331920,NM_000264.3,No,Yes PTCH1,F1147fs,Likely Oncogenic,Likely Loss-of-function,4,ENST00000331920,NM_000264.3,No,Yes EGR1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000239938,NM_001964.2,No,Yes NF1,V1398D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,R1276Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,R1204W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,R1391G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,K1436Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,R1204G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,R1391S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,R1276P,Oncogenic,Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,L90P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,Y489C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,R2429*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,T1324N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,K1423E,Oncogenic,Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,L90R,Inconclusive,Inconclusive,4,ENST00000356175,NM_000267.3,No,Yes NF1,L1301R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,G629R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,E1356G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes NF1,S1463F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000356175,NM_000267.3,No,Yes PHOX2B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000226382,NM_003924.3,No,Yes FBXW7,S462Y,Likely Neutral,Likely Neutral,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,T15insVR,Likely Neutral,Likely Neutral,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,W425C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,D520N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,R689Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,A503V,Likely Neutral,Likely Neutral,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,I347M,Likely Neutral,Likely Neutral,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,R465L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,R479H,Likely Oncogenic,Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,R479P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,R505L,Oncogenic,Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,R505C,Oncogenic,Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,R465C,Oncogenic,Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,R465H,Likely Oncogenic,Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,V154I,Likely Neutral,Likely Neutral,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,V514F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,R689W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,T205A,Likely Neutral,Likely Gain-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,R658Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,G423V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,G423R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,R479L,Likely Oncogenic,Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,S562L,Likely Neutral,Likely Neutral,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,K11R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,R479Q,Oncogenic,Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,D480N,Likely Neutral,Likely Neutral,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,S227A,Likely Oncogenic,Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes FBXW7,Y545C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000281708,NM_033632.3,No,Yes POLD1,S478N,Likely Oncogenic,Loss-of-function,4,ENST00000440232,NM_002691.3,No,Yes NKX3-1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380871,NM_006167.3,No,Yes FGFR3,M528I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,E466K,Inconclusive,Inconclusive,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,N540K,Oncogenic,Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,G380E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,R640W,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,R669G,Likely Oncogenic,Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,K403fs*93,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,K508M,Inconclusive,Inconclusive,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,Q209H,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,A257V,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,I538V,Likely Oncogenic,Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,A391V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,L608V,Inconclusive,Inconclusive,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,K650E,Oncogenic,Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,R248_S249insC,Likely Oncogenic,Likely Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,G382D,Inconclusive,Inconclusive,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,V555L,Inconclusive,Inconclusive,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,N540S,Likely Oncogenic,Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,V555M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,E140K,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,S371C,Likely Oncogenic,Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,Y373C,Oncogenic,Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,C582F,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,N653H,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,Y647C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,P63S,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,P572A,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,R621H,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,R603Q,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,R248C,Oncogenic,Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,V677I,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,G697C,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,K650N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,D641G,Likely Oncogenic,Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,E322K,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,P283S,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,G375C,Likely Oncogenic,Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,A265V,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,A265T,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,D617G,Likely Neutral,Likely Loss-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,I538F,Inconclusive,Inconclusive,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,K650M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,A391E,Likely Oncogenic,Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,H643D,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,A500T,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,G380R,Likely Oncogenic,Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,H284fs*10,Likely Oncogenic,Likely Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,K650R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,G370C,Likely Oncogenic,Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,G346E,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,K650T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,G66fs*32,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,G637W,Likely Neutral,Likely Loss-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,T79S,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,E627D,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,T311fs*55,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,F384L,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,P716H,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,D646Y,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,V630M,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,R248H,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,K650Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,D641N,Likely Oncogenic,Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,S249C,Oncogenic,Gain-of-function,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,T689M,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,E686K,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No FGFR3,E194K,Likely Neutral,Likely Neutral,4,ENST00000260795,NM_000142.4,Yes,No RAD51B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000487270,NM_133509.3,No,Yes RAD51B,R47*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000487270,NM_133509.3,No,Yes POT1,S322L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357628,NM_015450.2,No,Yes POT1,R117C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357628,NM_015450.2,No,Yes POT1,Y36N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357628,NM_015450.2,No,Yes POT1,Y89C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357628,NM_015450.2,No,Yes POT1,Q94E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357628,NM_015450.2,No,Yes POT1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357628,NM_015450.2,No,Yes POT1,Y223C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357628,NM_015450.2,No,Yes POT1,R273L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357628,NM_015450.2,No,Yes POT1,I78T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357628,NM_015450.2,No,Yes ALK,I1171T,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,F1174S,Likely Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,E1242K,Likely Neutral,Likely Neutral,4,ENST00000389048,NM_004304.4,Yes,No ALK,M1328I,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,Q1064R,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,F1245C,Likely Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,L1198P,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,S1206F,Inconclusive,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,S1206R,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,V597A,Likely Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,G1123S,Inconclusive,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,D1349H,Likely Neutral,Likely Neutral,4,ENST00000389048,NM_004304.4,Yes,No ALK,R401Q,Likely Neutral,Likely Neutral,4,ENST00000389048,NM_004304.4,Yes,No ALK,R1275Q,Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,R1464*,Likely Neutral,Likely Neutral,4,ENST00000389048,NM_004304.4,Yes,No ALK,R1192P,Likely Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,L1198F,Likely Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,F1174L,Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,I1171S,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,F1174I,Likely Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,T1343I,Likely Neutral,Likely Neutral,4,ENST00000389048,NM_004304.4,Yes,No ALK,G1202R,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,D1091N,Likely Neutral,Likely Neutral,4,ENST00000389048,NM_004304.4,Yes,No ALK,T1151R,Inconclusive,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,M1166R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,E1197K,Inconclusive,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,I1170S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,C1156F,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,K1062M,Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,H694R,Likely Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,E1210K,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,R1275L,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,C1156Y,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,N1178H,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,R1060H,Likely Neutral,Likely Neutral,4,ENST00000389048,NM_004304.4,Yes,No ALK,L1152P,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,G1128A,Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,G881D,Likely Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,E1384K,Likely Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,F1174V,Likely Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,R401L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,Y1278S,Likely Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,F1245V,Likely Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,D1270G,Likely Neutral,Neutral,4,ENST00000389048,NM_004304.4,Yes,No ALK,S1206Y,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,I1171N,Likely Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,L1122V,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,I1170N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,A1234T,Likely Neutral,Likely Neutral,4,ENST00000389048,NM_004304.4,Yes,No ALK,T1151dup,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,G1123D,Inconclusive,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,L1196Q,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,T1151M,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,A1200V,Likely Neutral,Likely Neutral,4,ENST00000389048,NM_004304.4,Yes,No ALK,P1139S,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,T1151K,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,D1203N,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,R291C,Inconclusive,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,R1231Q,Likely Neutral,Likely Neutral,4,ENST00000389048,NM_004304.4,Yes,No ALK,T1087I,Likely Neutral,Likely Neutral,4,ENST00000389048,NM_004304.4,Yes,No ALK,G1128S,Inconclusive,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,F1174C,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,A1099T,Likely Neutral,Likely Neutral,4,ENST00000389048,NM_004304.4,Yes,No ALK,I1183T,Likely Neutral,Likely Neutral,4,ENST00000389048,NM_004304.4,Yes,No ALK,S1206C,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,L1196M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,V1180L,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,G1269S,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,G1201E,Inconclusive,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,L1152R,Resistance,Inconclusive,4,ENST00000389048,NM_004304.4,Yes,No ALK,G1269A,Likely Oncogenic,Gain-of-function,4,ENST00000389048,NM_004304.4,Yes,No ALK,G1286R,Likely Neutral,Likely Neutral,4,ENST00000389048,NM_004304.4,Yes,No ALK,I1250T,Likely Neutral,Likely Neutral,4,ENST00000389048,NM_004304.4,Yes,No ALK,L1204F,Likely Neutral,Likely Neutral,4,ENST00000389048,NM_004304.4,Yes,No ARID5B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000279873,NM_032199.2,No,Yes ATM,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,R1575H,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,R2691C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,D2870A,Inconclusive,Inconclusive,4,ENST00000278616,NM_000051.3,No,Yes ATM,E2039K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,H2554D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,L2427_R2428del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,R337S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,F2827C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,A59S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,P960H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,L2427P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,S2394L,Likely Oncogenic,Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,N1650S,Inconclusive,Inconclusive,4,ENST00000278616,NM_000051.3,No,Yes ATM,T1743I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,Q2730P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,T2031I,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,A1742P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,P604S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,H1380Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,R3008C,Oncogenic,Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,R45Q,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,S2855_V2856delinsRI,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,V1941L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,L1322I,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,A2274T,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,K1807E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,S2592C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,L581V,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,T2947S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,H2872Q,Inconclusive,Inconclusive,4,ENST00000278616,NM_000051.3,No,Yes ATM,S1455R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,L2452P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,R2034P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,L2338P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,R2506_N2543del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,R2642S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,G2765S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,S2707C,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,F1025L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,S49C,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,E2668G,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,L1874F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,P2974L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,K224E,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,F858L,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,R2832C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,L1420F,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,D2708N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,Y2019C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,K1992T,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,R2486G,Inconclusive,Inconclusive,4,ENST00000278616,NM_000051.3,No,Yes ATM,H2038Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,L1956H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,D1682H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,N2326_K2363del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,P1054R,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,L589R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,S2685T,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,C2488Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,D1853V,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,D1853N,Inconclusive,Inconclusive,4,ENST00000278616,NM_000051.3,No,Yes ATM,I323V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,R2547_S2549del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,Y1961C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,T2666A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,S333F,Inconclusive,Inconclusive,4,ENST00000278616,NM_000051.3,No,Yes ATM,R3008H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,L546V,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,I1681V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,F2732V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,G2718_K2756del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,L2890V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,V2424G,Likely Oncogenic,Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,N2875K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,V1841I,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,A2067D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,N2875T,Inconclusive,Inconclusive,4,ENST00000278616,NM_000051.3,No,Yes ATM,A220V,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,P292L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,V519I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,D1682Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,S824F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,E1978*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,P2699L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,A2062V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,S1691R,Likely Neutral,Likely Neutral,4,ENST00000278616,NM_000051.3,No,Yes ATM,L1465P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,K2749I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes ATM,R3047*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000278616,NM_000051.3,No,Yes MLH1,R659P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000231790,NM_000249.3,No,Yes MLH1,A681T,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,G67R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000231790,NM_000249.3,No,Yes MLH1,A111P,Likely Oncogenic,Loss-of-function,4,ENST00000231790,NM_000249.3,No,Yes MLH1,R265S,Likely Oncogenic,Loss-of-function,4,ENST00000231790,NM_000249.3,No,Yes MLH1,L559R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000231790,NM_000249.3,No,Yes MLH1,V506A,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,K618T,Likely Neutral,Likely Neutral,4,ENST00000231790,NM_000249.3,No,Yes MLH1,R755S,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,L582F,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,G67W,Likely Oncogenic,Loss-of-function,4,ENST00000231790,NM_000249.3,No,Yes MLH1,N38S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000231790,NM_000249.3,No,Yes MLH1,Q689R,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,I219V,Likely Neutral,Likely Neutral,4,ENST00000231790,NM_000249.3,No,Yes MLH1,P603R,Likely Neutral,Likely Neutral,4,ENST00000231790,NM_000249.3,No,Yes MLH1,R217C,Likely Neutral,Likely Neutral,4,ENST00000231790,NM_000249.3,No,Yes MLH1,P648S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000231790,NM_000249.3,No,Yes MLH1,E433Q,Likely Neutral,Likely Neutral,4,ENST00000231790,NM_000249.3,No,Yes MLH1,E172K,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,T117M,Likely Oncogenic,Gain-of-function,4,ENST00000231790,NM_000249.3,No,Yes MLH1,L622H,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,T82A,Likely Oncogenic,Loss-of-function,4,ENST00000231790,NM_000249.3,No,Yes MLH1,P654L,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,N551T,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,D737V,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,A120S,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,G101S,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,P648L,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,V716M,Likely Neutral,Likely Neutral,4,ENST00000231790,NM_000249.3,No,Yes MLH1,V384D,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000231790,NM_000249.3,No,Yes MLH1,M587V,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,R659L,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,R389Q,Likely Neutral,Likely Neutral,4,ENST00000231790,NM_000249.3,No,Yes MLH1,L550P,Inconclusive,Inconclusive,4,ENST00000231790,NM_000249.3,No,Yes MLH1,R265C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000231790,NM_000249.3,No,Yes MLH1,R725C,Likely Neutral,Likely Neutral,4,ENST00000231790,NM_000249.3,No,Yes MLH1,K618A,Likely Neutral,Likely Neutral,4,ENST00000231790,NM_000249.3,No,Yes MLH1,L749P,Likely Oncogenic,Loss-of-function,4,ENST00000231790,NM_000249.3,No,Yes GNB1,K57T,Oncogenic,Gain-of-function,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,K57E,Oncogenic,Gain-of-function,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,R304G,Oncogenic,Gain-of-function,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,S316G,Oncogenic,Gain-of-function,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,I80N,Oncogenic,Gain-of-function,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,I269T,Oncogenic,Gain-of-function,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,I80T,Oncogenic,Gain-of-function,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,H225L,Oncogenic,Gain-of-function,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,G41*,Likely Neutral,Likely Neutral,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,H54N,Oncogenic,Gain-of-function,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,R214*,Likely Neutral,Likely Neutral,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,G272R,Oncogenic,Gain-of-function,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,R256H,Likely Neutral,Likely Neutral,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,K89E,Oncogenic,Gain-of-function,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,N230S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,R283C,Likely Neutral,Likely Neutral,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,D76G,Oncogenic,Gain-of-function,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,D118Y,Oncogenic,Gain-of-function,4,ENST00000378609,NM_001282539.1,Yes,No GNB1,A11V,Oncogenic,Gain-of-function,4,ENST00000378609,NM_001282539.1,Yes,No RRAS,Q87L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000246792,NM_006270.3,Yes,No RRAS,Q72H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000246792,NM_006270.3,Yes,No BTG1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256015,NM_001731.2,No,Yes EPCAM,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263735,NM_002354.2,No,Yes EPCAM,3' Deletion,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263735,NM_002354.2,No,Yes RELN,R2290H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000428762,NM_005045.3,No,No RELN,R1742W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000428762,NM_005045.3,No,No RELN,R2290C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000428762,NM_005045.3,No,No RELN,R1742Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000428762,NM_005045.3,No,No RAD51C,G264S,Likely Neutral,Neutral,4,ENST00000337432,NM_058216.2,No,Yes RAD51C,R258H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000337432,NM_058216.2,No,Yes RAD51C,R193W,Resistance,Inconclusive,4,ENST00000337432,NM_058216.2,No,Yes RAD51C,H192delinsGG,Resistance,Inconclusive,4,ENST00000337432,NM_058216.2,No,Yes RAD51C,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000337432,NM_058216.2,No,Yes RAD51C,R193L,Resistance,Inconclusive,4,ENST00000337432,NM_058216.2,No,Yes RAD51C,D159N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000337432,NM_058216.2,No,Yes RAD51C,A126T,Likely Neutral,Neutral,4,ENST00000337432,NM_058216.2,No,Yes RAD51C,L138F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000337432,NM_058216.2,No,Yes FGFR2,H544Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,M640I,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,E695K,Likely Neutral,Likely Loss-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,V564F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,C383R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,R399Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,Exon 18 deletion,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,H213Y,Inconclusive,Inconclusive,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,G613S,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,N549T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,C382Y,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,G701S,Inconclusive,Inconclusive,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,G542E,Likely Neutral,Likely Loss-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,E565A,Inconclusive,Inconclusive,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,C62Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,K659E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,G305R,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,H242Y,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,E475K,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,R625Q,Likely Neutral,Likely Loss-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,N549H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,S252W,Oncogenic,Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,M391R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,L617M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,L560F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,V564I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,S791T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,R210Q,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,H416R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,K526E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,R399*,Likely Neutral,Likely Loss-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,W290C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,P253L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,I547V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,P582L,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,I288_E295delinsT,Inconclusive,Inconclusive,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,G227E,Likely Neutral,Likely Loss-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,Q212K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,N549K,Oncogenic,Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,R251Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,A264T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,L770V,Inconclusive,Inconclusive,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,E160K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,A371V,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,N549S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,R6P,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,N82K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,R330W,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,Q227E,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,R203C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,C278F,Likely Neutral,Likely Loss-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,G364E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,T729S,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,E219K,Inconclusive,Inconclusive,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,Y375C,Oncogenic,Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,H167_N173del,Oncogenic,Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,Y328N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,K517R,Likely Neutral,Likely Loss-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,F276C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,C287R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,P253R,Oncogenic,Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,E565G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,K641R,Oncogenic,Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,S267_D273dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,D101Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,M722I,Likely Neutral,Likely Loss-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,I642V,Likely Neutral,Likely Loss-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,E731K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,M186T,Likely Neutral,Likely Loss-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,G271E,Likely Neutral,Likely Loss-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,N549D,Inconclusive,Inconclusive,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,V248D,Inconclusive,Inconclusive,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,R664W,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,E718K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,A389T,Inconclusive,Inconclusive,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,E163K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,P303L,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,K659M,Inconclusive,Inconclusive,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,S372C,Inconclusive,Inconclusive,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,M537I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,Q259*,Likely Neutral,Likely Loss-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,Y381D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,C382R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,L617V,Inconclusive,Inconclusive,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,V754I,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,P708S,Likely Neutral,Likely Loss-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,E636K,Inconclusive,Inconclusive,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,V392A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,L617F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,L33S,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,R203H,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,A67V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,R678G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,W290R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,K659N,Likely Oncogenic,Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,T341P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,A648T,Likely Neutral,Likely Loss-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,D530N,Likely Neutral,Likely Loss-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,I422V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,V395D,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,M535I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,D471N,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,K310R,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,K641N,Resistance,Inconclusive,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,W290_I291delinsC,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358487,NM_000141.4,Yes,No FGFR2,E596K,Likely Neutral,Likely Neutral,4,ENST00000358487,NM_000141.4,Yes,No NOTCH1,G230R,Likely Neutral,Likely Neutral,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,F1592S,Likely Oncogenic,Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,Q2405Rfs*17,Likely Oncogenic,Likely Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,V1605del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,P2415del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,L1678P,Likely Oncogenic,Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,I1680N,Likely Oncogenic,Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,R1598P,Likely Oncogenic,Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,A465T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,Truncating mutations in the PEST domain,Likely Oncogenic,Likely Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,G309R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,I1718T,Likely Oncogenic,Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,H2428Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,L1596H,Likely Oncogenic,Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,G310R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,T311P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,N386T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,V1671I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,E455K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,Truncating mutations upstream of transactivation domain,Oncogenic,Likely Loss-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,R1608S,Likely Neutral,Likely Neutral,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,L1593P,Likely Oncogenic,Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,I1616T,Likely Oncogenic,Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,V1576E,Likely Oncogenic,Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,P2412T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,V1578del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,A2425T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,L1574P,Oncogenic,Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,Q2416*,Likely Oncogenic,Likely Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,L1600P,Likely Oncogenic,Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,C440F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,A1701P,Likely Oncogenic,Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,G2420C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,L2429V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,P2417A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,F357del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,R1594Q,Likely Oncogenic,Loss-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,G2430A,Likely Oncogenic,Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,V1676D,Likely Oncogenic,Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,D464N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,I1616N,Likely Oncogenic,Gain-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,T349P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes NOTCH1,G347S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000277541,NM_017617.3,Yes,Yes PIK3R1,X582_splice,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,R503W,Oncogenic,Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,E439del,Likely Oncogenic,Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,R162*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,R348*,Oncogenic,Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,E218*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,L380del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,Y452H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,N564D,Oncogenic,Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,K567E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,D560Y,Likely Oncogenic,Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,Q579_L581del,Oncogenic,Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,R574fs,Oncogenic,Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,K459_S460delinsN,Oncogenic,Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,T576del,Oncogenic,Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,K379E,Oncogenic,Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,X475_splice,Likely Oncogenic,Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,X434_splice,Likely Oncogenic,Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,I559_D560insDKRMNS,Oncogenic,Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,K448_Y452del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,N564K,Likely Oncogenic,Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,G376R,Likely Oncogenic,Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,W624R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,K288Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,W333R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,E137K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,R262T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,W237_Y242del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,E160*,Oncogenic,Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,L370fs,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274335,NM_181523.2,No,Yes PIK3R1,L372_R373del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000274335,NM_181523.2,No,Yes SUZ12,E610G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000322652,NM_015355.2,No,Yes SUZ12,D605V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000322652,NM_015355.2,No,Yes SUZ12,E610V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000322652,NM_015355.2,No,Yes SUZ12,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000322652,NM_015355.2,No,Yes SUZ12,F603L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000322652,NM_015355.2,No,Yes CHEK2,E64K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000328354,NM_007194.3,No,Yes CHEK2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000328354,NM_007194.3,No,Yes CHEK2,E321K,Likely Oncogenic,Loss-of-function,4,ENST00000328354,NM_007194.3,No,Yes CHEK2,R145W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000328354,NM_007194.3,No,Yes CHEK2,H371Y,Likely Oncogenic,Loss-of-function,4,ENST00000328354,NM_007194.3,No,Yes CHEK2,R117G,Likely Oncogenic,Loss-of-function,4,ENST00000328354,NM_007194.3,No,Yes CHEK2,K373E,Oncogenic,Loss-of-function,4,ENST00000328354,NM_007194.3,No,Yes CHEK2,E161del,Likely Oncogenic,Loss-of-function,4,ENST00000328354,NM_007194.3,No,Yes CHEK2,R181C,Inconclusive,Inconclusive,4,ENST00000328354,NM_007194.3,No,Yes CHEK2,P85L,Likely Neutral,Neutral,4,ENST00000328354,NM_007194.3,No,Yes CHEK2,R346H,Inconclusive,Inconclusive,4,ENST00000328354,NM_007194.3,No,Yes CHEK2,R180H,Inconclusive,Inconclusive,4,ENST00000328354,NM_007194.3,No,Yes CHEK2,S372F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000328354,NM_007194.3,No,Yes CHEK2,I189V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000328354,NM_007194.3,No,Yes CHEK2,I157T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000328354,NM_007194.3,No,Yes CHEK2,S428F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000328354,NM_007194.3,No,Yes TNFRSF14,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000355716,NM_003820.2,No,Yes XRCC2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000359321,NM_005431.1,No,Yes XRCC2,R188H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000359321,NM_005431.1,No,Yes RAC1,P34R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000356142,NM_018890.3,Yes,No RAC1,Q61R,Likely Oncogenic,Gain-of-function,4,ENST00000356142,NM_018890.3,Yes,No RAC1,P29S,Oncogenic,Gain-of-function,4,ENST00000356142,NM_018890.3,Yes,No RAC1,C18Y,Likely Oncogenic,Gain-of-function,4,ENST00000356142,NM_018890.3,Yes,No RAC1,P29L,Oncogenic,Gain-of-function,4,ENST00000356142,NM_018890.3,Yes,No RAC1,C176Y,Likely Oncogenic,Gain-of-function,4,ENST00000356142,NM_018890.3,Yes,No RAC1,G12V,Oncogenic,Gain-of-function,4,ENST00000356142,NM_018890.3,Yes,No PIK3R3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262741,NM_003629.3,No,Yes CALR,Exon 9 insertions,Likely Neutral,Likely Neutral,4,ENST00000316448,NM_004343.3,Yes,No CALR,Exon 9 deletions,Likely Neutral,Likely Neutral,4,ENST00000316448,NM_004343.3,Yes,No CALR,C-terminal truncating mutations,Likely Oncogenic,Likely Gain-of-function,4,ENST00000316448,NM_004343.3,Yes,No ERCC4,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000311895,NM_005236.2,No,Yes ERCC4,S786F,Oncogenic,Loss-of-function,4,ENST00000311895,NM_005236.2,No,Yes ERCC4,L230P,Oncogenic,Loss-of-function,4,ENST00000311895,NM_005236.2,No,Yes ERCC4,E875G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000311895,NM_005236.2,No,Yes ERCC4,R689S,Oncogenic,Loss-of-function,4,ENST00000311895,NM_005236.2,No,Yes NF2,L46R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000338641,NM_000268.3,No,Yes NF2,E106G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000338641,NM_000268.3,No,Yes NF2,L535P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000338641,NM_000268.3,No,Yes NF2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000338641,NM_000268.3,No,Yes NF2,K79E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000338641,NM_000268.3,No,Yes NF2,Q324L,Likely Neutral,Likely Neutral,4,ENST00000338641,NM_000268.3,No,Yes NF2,T352M,Likely Neutral,Likely Neutral,4,ENST00000338641,NM_000268.3,No,Yes NF2,K413E,Inconclusive,Inconclusive,4,ENST00000338641,NM_000268.3,No,Yes NF2,Q538P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000338641,NM_000268.3,No,Yes NF2,L64P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000338641,NM_000268.3,No,Yes NF2,A211D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000338641,NM_000268.3,No,Yes CARD11,E626K,Likely Oncogenic,Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,C49S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,S250P,Oncogenic,Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,G126D,Likely Oncogenic,Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,F115L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,E134G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,V119E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,F130Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,N62Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,E93D,Oncogenic,Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,C49Y,Likely Oncogenic,Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,D387V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,G123D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,F97Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,Y361C,Inconclusive,Inconclusive,4,ENST00000396946,NM_032415.4,Yes,No CARD11,G123S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,K215M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,D230N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,F130I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,L251P,Oncogenic,Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,R113Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,D357E,Resistance,Inconclusive,4,ENST00000396946,NM_032415.4,Yes,No CARD11,D401N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,T112I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No CARD11,T117A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396946,NM_032415.4,Yes,No NOTCH3,N-terminal truncating mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263388,NM_000435.2,Yes,Yes NOTCH3,C-terminal truncating mutations,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263388,NM_000435.2,Yes,Yes PTPRT,R1209W,Likely Oncogenic,Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,F74S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,V648G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,T1365M,Likely Oncogenic,Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,Q984K,Likely Oncogenic,Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,R453C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,V1014M,Likely Oncogenic,Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,Y280H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,T863M,Likely Oncogenic,Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,A1041E,Oncogenic,Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,R1059L,Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,Promoter Hypermethylation,Oncogenic,Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,D944G,Likely Oncogenic,Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,S492F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,T605M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,Y412F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,A707T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,L708P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,I395V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,K218T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,N510K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,N1125I,Likely Oncogenic,Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,A209T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,Q479E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,F248S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes PTPRT,R1343L,Likely Oncogenic,Loss-of-function,4,ENST00000373198,NM_133170.3,No,Yes CIITA,S11P,Likely Neutral,Likely Neutral,4,ENST00000324288,NM_001286402,No,Yes CIITA,C715Y,Likely Oncogenic,Loss-of-function,4,ENST00000324288,NM_001286402,No,Yes CIITA,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000324288,NM_001286402,No,Yes CIITA,D71N,Likely Neutral,Likely Neutral,4,ENST00000324288,NM_001286402,No,Yes CIITA,T636M,Likely Oncogenic,Loss-of-function,4,ENST00000324288,NM_001286402,No,Yes RIT1,M90I,Oncogenic,Gain-of-function,4,ENST00000368323,NM_006912.5,Yes,No RIT1,Q40L,Likely Neutral,Likely Neutral,4,ENST00000368323,NM_006912.5,Yes,No RIT1,Y89H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368323,NM_006912.5,Yes,No RIT1,A77S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368323,NM_006912.5,Yes,No RIT1,T83P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368323,NM_006912.5,Yes,No RIT1,A77P,Oncogenic,Gain-of-function,4,ENST00000368323,NM_006912.5,Yes,No RIT1,E81G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368323,NM_006912.5,Yes,No RIT1,T83del,Oncogenic,Gain-of-function,4,ENST00000368323,NM_006912.5,Yes,No RIT1,T76insTLDT,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368323,NM_006912.5,Yes,No RIT1,R122L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368323,NM_006912.5,Yes,No RIT1,Q79L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368323,NM_006912.5,Yes,No RIT1,F82L,Oncogenic,Gain-of-function,4,ENST00000368323,NM_006912.5,Yes,No RIT1,A57G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368323,NM_006912.5,Yes,No RIT1,A77T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368323,NM_006912.5,Yes,No IRF8,K108E,Likely Oncogenic,Loss-of-function,4,ENST00000268638,NM_002163.2,No,Yes IRF8,T80A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000268638,NM_002163.2,No,Yes IRF8,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000268638,NM_002163.2,No,Yes SOX17,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000297316,NM_022454.3,No,Yes SOX17,S403I,Likely Neutral,Likely Neutral,4,ENST00000297316,NM_022454.3,No,Yes SOX17,A96G,Likely Neutral,Likely Neutral,4,ENST00000297316,NM_022454.3,No,Yes AXL,A273V,Likely Oncogenic,Inconclusive,4,ENST00000301178,NM_021913.4,Yes,No CSF3R,T618I,Oncogenic,Gain-of-function,4,ENST00000361632,NM_000760.3,Yes,No TMPRSS2,T112M,Inconclusive,Inconclusive,4,ENST00000398585,NM_001135099.1,No,No BTG2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000290551,NM_006763,No,Yes BACH2,T817A,Likely Neutral,Likely Neutral,4,ENST00000257749,NM_001170794.1,No,Yes BACH2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000257749,NM_001170794.1,No,Yes BACH2,E788K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000257749,NM_001170794.1,No,Yes BACH2,L24P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000257749,NM_001170794.1,No,Yes BACH2,S521A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000257749,NM_001170794.1,No,Yes BACH2,T519A,Likely Neutral,Likely Neutral,4,ENST00000257749,NM_001170794.1,No,Yes FGFR1,V592M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,R220C,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,A635T,Likely Neutral,Likely Loss-of-function,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,R840Q,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,T59I,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,D128V,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,G734S,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,P514L,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,S269N,Likely Neutral,Likely Loss-of-function,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,N224fs*8,Likely Neutral,Likely Loss-of-function,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,R506Q,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,E623G,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,S467F,Likely Neutral,Likely Loss-of-function,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,E701K,Likely Neutral,Likely Loss-of-function,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,K687M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,V695L,Likely Neutral,Likely Loss-of-function,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,E498K,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,R476W,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,A154D,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,V782A,Likely Neutral,Likely Loss-of-function,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,R281W,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,S158L,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,A294V,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,A54T,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,S619T,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,R677W,Likely Neutral,Likely Loss-of-function,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,P184S,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,T371M,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,Kinase Domain Duplication,Oncogenic,Gain-of-function,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,K687*,Likely Neutral,Likely Loss-of-function,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,A299S,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,K687E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,D351N,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,M487V,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,D166N,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,T174R,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,N577K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,T350A,Likely Neutral,Likely Loss-of-function,4,ENST00000425967,NM_001174067.1,Yes,No FGFR1,D128N,Likely Neutral,Likely Neutral,4,ENST00000425967,NM_001174067.1,Yes,No NOTCH2,2010_2471trunc,Likely Oncogenic,Likely Gain-of-function,4,ENST00000256646,NM_024408.3,Yes,Yes NOTCH2,1_2009trunc,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256646,NM_024408.3,Yes,Yes DTX1,A56T,Likely Neutral,Likely Neutral,4,ENST00000257600,NM_004416.2,No,Yes DTX1,F17Y,Likely Neutral,Likely Neutral,4,ENST00000257600,NM_004416.2,No,Yes DTX1,W30*,Likely Oncogenic,Loss-of-function,4,ENST00000257600,NM_004416.2,No,Yes DTX1,H34N,Likely Neutral,Likely Neutral,4,ENST00000257600,NM_004416.2,No,Yes DTX1,H34R,Likely Neutral,Likely Neutral,4,ENST00000257600,NM_004416.2,No,Yes DTX1,P11S,Likely Neutral,Likely Neutral,4,ENST00000257600,NM_004416.2,No,Yes DTX1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000257600,NM_004416.2,No,Yes DTX1,D75A,Likely Oncogenic,Loss-of-function,4,ENST00000257600,NM_004416.2,No,Yes DTX1,E33D,Likely Neutral,Likely Neutral,4,ENST00000257600,NM_004416.2,No,Yes DTX1,G58D,Likely Neutral,Likely Neutral,4,ENST00000257600,NM_004416.2,No,Yes DTX1,H34Y,Likely Neutral,Likely Neutral,4,ENST00000257600,NM_004416.2,No,Yes DTX1,F82L,Likely Neutral,Likely Neutral,4,ENST00000257600,NM_004416.2,No,Yes DTX1,E49D,Likely Oncogenic,Loss-of-function,4,ENST00000257600,NM_004416.2,No,Yes DTX1,P11fs*2,Likely Oncogenic,Loss-of-function,4,ENST00000257600,NM_004416.2,No,Yes DTX1,Q81L,Likely Neutral,Likely Neutral,4,ENST00000257600,NM_004416.2,No,Yes PIK3R2,A36E,Likely Neutral,Likely Neutral,4,ENST00000222254,NM_005027.3,No,Yes PIK3R2,D557H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000222254,NM_005027.3,No,Yes PIK3R2,K376N,Likely Neutral,Likely Neutral,4,ENST00000222254,NM_005027.3,No,Yes PIK3R2,N561D,Oncogenic,Gain-of-function,4,ENST00000222254,NM_005027.3,No,Yes PIK3R2,A727V,Likely Neutral,Likely Neutral,4,ENST00000222254,NM_005027.3,No,Yes PIK3R2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000222254,NM_005027.3,No,Yes PIK3R2,S273C,Likely Neutral,Likely Neutral,4,ENST00000222254,NM_005027.3,No,Yes PIK3R2,G373R,Likely Oncogenic,Gain-of-function,4,ENST00000222254,NM_005027.3,No,Yes PIK3R2,A171V,Oncogenic,Gain-of-function,4,ENST00000222254,NM_005027.3,No,Yes MAP3K1,E1286V,Likely Neutral,Likely Neutral,4,ENST00000399503,NM_005921.1,No,Yes MAP3K1,T779fs,Likely Oncogenic,Likely Loss-of-function,4,ENST00000399503,NM_005921.1,No,Yes MAP3K1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000399503,NM_005921.1,No,Yes FANCD2,L153S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000383807,NM_001018115.1,No,Yes FANCD2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000383807,NM_001018115.1,No,Yes CHEK1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000428830,NM_001274.5,No,Yes MSH6,S144I,Likely Neutral,Likely Neutral,4,ENST00000234420,NM_000179.2,No,Yes MSH6,R976H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000234420,NM_000179.2,No,Yes MSH6,G39E,Inconclusive,Inconclusive,4,ENST00000234420,NM_000179.2,No,Yes MSH6,F1088Lfs*5,Likely Oncogenic,Likely Loss-of-function,4,ENST00000234420,NM_000179.2,No,Yes MSH6,R361H,Inconclusive,Inconclusive,4,ENST00000234420,NM_000179.2,No,Yes MSH6,T1219I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000234420,NM_000179.2,No,Yes MSH6,R1076C,Inconclusive,Inconclusive,4,ENST00000234420,NM_000179.2,No,Yes MSH6,V509A,Inconclusive,Inconclusive,4,ENST00000234420,NM_000179.2,No,Yes MSH6,R1095H,Likely Neutral,Likely Neutral,4,ENST00000234420,NM_000179.2,No,Yes MSH6,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000234420,NM_000179.2,No,Yes HNF1A,P291Qfs*51,Likely Oncogenic,Likely Loss-of-function,4,ENST00000257555,NM_000545.5,No,Yes HNF1A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000257555,NM_000545.5,No,Yes HNF1A,I27L,Inconclusive,Inconclusive,4,ENST00000257555,NM_000545.5,No,Yes HNF1A,T196A,Likely Neutral,Neutral,4,ENST00000257555,NM_000545.5,No,Yes BRCA2,T3013I,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,F2600C,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Y2726C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,K2498E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2929W,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,C3069G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G1771D,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D1280V,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S2704F,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P1819S,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,C554W,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,K513R,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S3020C,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,T1723Sfs*2,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2625K,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P2785L,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,K2849E,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S1760A,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D2965H,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,T3349A,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S2988G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2686P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S2695L,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,N987I,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P3039L,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2596E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,F2562V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D935N,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2842L,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,H1966Y,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D2312V,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D3073G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2581W,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,T2662M,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L3011P,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,H2623Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2787H,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D2723V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S3070F,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A1170V,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,I2285V,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,M2676T,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,I332M,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2602T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S2697N,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Q1998Nfs*4,Resistance,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2510P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,E2769Q,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S2509N,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S869L,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D1352Y,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,T2681R,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V2728A,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,K607T,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,E2757V,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V2969M,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P2639A,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S206C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2901D,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,I2675V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A2756G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,I2627F,Likely Oncogenic,Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Y3098H,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Q2858R,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2688P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2418G,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S1424C,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,I1349T,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A2643G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,N1878K,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Y3092S,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2585R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2659K,Likely Oncogenic,Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,T2250A,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D2680G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,N56T,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2587F,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D2606G,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Y3035C,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S2483N,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L3101P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V2908G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A2786P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G3003E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,E2847K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Y3006D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P2767S,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S3058G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,K2630Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S1172L,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,W2626C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S1733F,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G3076V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,M192T,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,N517S,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A2603P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V3079I,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D2611G,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S2533C,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,N2113S,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Q2925H,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2488S,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,I2672V,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,C2646W,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,C1365Y,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2653P,Likely Oncogenic,Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,N3124I,Oncogenic,Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S2806L,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2654P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P2800S,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,N588D,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D3170G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2609D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2812E,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S1869_N1877del,Resistance,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2973C,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2792P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,I3107T,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Q1396R,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D2723G,Likely Oncogenic,Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,E832Q,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2604P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,E2856A,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V2652G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Q2561P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L3101R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,T1302del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2865V,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V1306I,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A2770T,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Q2858K,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A2351G,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,E462G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A3088V,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,E2571G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2842C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,K1025_K1026delinsN*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P168T,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2659T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V3081A,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2824T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,E1382del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L929S,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,E3002D,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Q2829R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2584D,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Y2660D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Q2655R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P2800R,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,E3152K,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S196N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A2730V,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V159M,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D1420Y,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L1019V,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2973H,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2784W,Likely Oncogenic,Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,T2722R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V211I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,F2562L,Likely Oncogenic,Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,H2623R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A2951T,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D3112N,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Q2925K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V2466A,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2837E,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2896C,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A1847_M1890del,Resistance,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,F2873C,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2502C,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2787C,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,N2436I,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D2712N,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,N2048I,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2336H,Likely Oncogenic,Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A2730P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,F3146S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2502H,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,E3071D,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R259fs*15,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A2770D,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P2827S,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,K2729N,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V2687F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Q2561R,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,M927V,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2336P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V3072E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D806H,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V1790_A1996del,Resistance,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2991H,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,N319T,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,T2515I,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P655R,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,F1524V,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S1871_C1893del,Resistance,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,E3002K,Likely Oncogenic,Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A75P,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2768H,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,I2821T,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,T1354M,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,C3198R,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A3028P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,K3326*,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2625I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2659G,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2596R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G3086A,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,N3124K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2494Q,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R3384Q,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,H1918Y,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R1190W,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2748D,Likely Oncogenic,Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V1643A,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,H2074N,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,K169R,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,M784V,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L1904V,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P2589H,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,T630I,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2896H,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D3197G,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D3095E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,N372H,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,W2725L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D2723A,Likely Oncogenic,Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,E832G,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,F2642S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2862P,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G1194D,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,C1265S,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,E2981K,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2888C,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S384F,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R3007G,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2842H,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V894I,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A2351T,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,F2562C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P2735R,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,K2472T,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2724W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G173C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2793E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L3125H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A2851V,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A2632G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S2691F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2774R,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,T582P,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V2728I,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S2807L,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,F2794L,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2488G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,W2626R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S3123G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P2771L,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Y3092C,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P2532L,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S976I,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S2782N,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,I2495T,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S326R,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S2522F,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V1839_E1901del,Resistance,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,T1815_Y1894del,Resistance,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2108H,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G602R,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,N1102Y,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2609V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2508S,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2748S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,I2490T,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2274V,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D2679G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S2670L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G1529R,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A3029V,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2793R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2106P,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R3052Q,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,N1228D,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R18H,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,T2722A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,K2411T,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2784Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P2608A,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2520P,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,K2950N,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2972W,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2544S,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,I1929V,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,K1690N,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,T3033I,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Y42C,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G2813E,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2034C,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A248T,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Y3035S,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S142I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R174C,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L209F,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,A2717S,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,W2788S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2520Q,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,C3069R,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G3076R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2721H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,K722Q,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P375S,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S1834_G1892del,Resistance,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Q2384K,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,K1434I,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,V2652M,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Y3049C,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2647P,Likely Oncogenic,Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,W2788R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2318Q,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,T3211K,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D2723H,Likely Oncogenic,Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D2913E,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,I2944F,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Q3026E,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,K1872*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D191G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,C2765G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,P3063S,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,S2810G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2678G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,E2663V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,D2665G,Likely Neutral,Likely Neutral,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,L2396F,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,R3052W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,Q2925R,Inconclusive,Inconclusive,4,ENST00000380152,NM_000059.3,No,Yes BRCA2,G3076E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380152,NM_000059.3,No,Yes ZNRF3,P103A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000544604,NM_001206998.1,No,Yes BCOR,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000378444,NM_001123385.1,No,Yes BCOR,Internal Tandem Duplication,Likely Oncogenic,Likely Switch-of-function,4,ENST00000378444,NM_001123385.1,No,Yes ATRX,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373344,NM_000489.3,No,Yes ACVR1,G328V,Likely Oncogenic,Gain-of-function,4,ENST00000263640,NM_001111067.2,Yes,No ACVR1,R206H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263640,NM_001111067.2,Yes,No ACVR1,G328E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263640,NM_001111067.2,Yes,No ACVR1,G356D,Likely Oncogenic,Gain-of-function,4,ENST00000263640,NM_001111067.2,Yes,No ACVR1,Q207E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263640,NM_001111067.2,Yes,No NTHL1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219066,NM_002528.5,No,Yes DNMT3A,G800S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R899H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,K906N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,F751I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,Y436S,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,E342K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,C710S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L639R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,C537S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L547H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V872I,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,A575T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V339del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G413S,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,E428Q,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,S828N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,K518N,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,F701L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,C586Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R318Q,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G642E,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,E400D,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R736H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L637Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,F290S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,D438N,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,A741P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,S770W,Inconclusive,Inconclusive,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P307S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,S770L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,K826R,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G822D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,K272N,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,D857N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V687D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R803S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,S638F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R771L,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R309G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,F909C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,E733A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,Y359D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R836W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,C494F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,E477K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R596W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,Q573L,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,Y365C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V850I,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R181C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,N838D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,A662D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V636M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,Y793D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,D781G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L648P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P431S,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R19W,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V758del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,Y660C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,E30A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L344Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G302D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V563M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,A376D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G324V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,M548K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R183W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,E774K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R366H,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,S881I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G707D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,D579G,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R366S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,F731del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R598Q,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V649L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L901R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,F902del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L647R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,F755L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,I769N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,H739A,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G543C,Inconclusive,Inconclusive,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R688S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L295P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,W297del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G699D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,D668A,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,F794L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,K299N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G332R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R484W,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G646E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,C514F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P627R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,I898T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,D702G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,Y908C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R288W,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,I780T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R635W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P709L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R556S,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V759del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G869C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,T691I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R882H,Oncogenic,Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R676W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R771P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V778G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G308D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,D531N,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R379H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,C911F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,A192E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L815Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L508P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L737F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L754R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,D641G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V704M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,F731L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,A572D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V567del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G511R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,K455Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,W893S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,I705T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,T437M,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,I369N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G728D,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P580L,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P419T,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,H783R,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,M761I,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,T835M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,S378N,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G293V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,T316M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,K829R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,Y623D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G706R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R882P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P804S,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,Y533C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P849L,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,S352N,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P743S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,M801T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R720H,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,H789Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V716I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,D747A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,A525V,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,S267F,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,E545G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,A910V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,F734L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,E865V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V690D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V672G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,A571P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,Y735C,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R635Q,Inconclusive,Inconclusive,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R659H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P700L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,E281K,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,A825V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,A254T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R301W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,C583Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L653W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,F772L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,F752del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,D529N,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,S669F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R792H,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,A410T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,N879D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G685R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,Q886R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,C549R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G298E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,W860R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R631G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,F414S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R478W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R742P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,A884V,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,I695L,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,F868V,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,C497Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R729W,Inconclusive,Inconclusive,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L905R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,C562R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R749C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L650P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,S714C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V684D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P799A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R604Q,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,I407T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,A380T,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,K361R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,I495N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,E756A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G532S,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,H873N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,M880V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G796C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V759L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L813Q,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,A322T,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,S663W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,E907V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L798P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,W795C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,I661N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,W314S,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,C517R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,D768Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,L703V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P507R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V665L,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R736C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V657G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,H677R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,E814G,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,E426D,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,I292T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,D811V,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,N90S,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,S337L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R326S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,T645A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P777L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P424T,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V328D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P718R,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,A368T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,G550R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P385L,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,V675L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,F902S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,I310N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R882C,Oncogenic,Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,S312Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,D686Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R458P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,W581R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,C554Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P904L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,Q527H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,P896S,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,N717S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,R474G,Likely Neutral,Likely Neutral,4,ENST00000264709,NM_022552.4,No,Yes DNMT3A,N797D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264709,NM_022552.4,No,Yes CDKN2B,D86N,Oncogenic,Loss-of-function,4,ENST00000276925,NM_004936.3,No,Yes CDKN2B,Hypermethylation,Oncogenic,Loss-of-function,4,ENST00000276925,NM_004936.3,No,Yes CDKN2B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000276925,NM_004936.3,No,Yes CDKN2B,E35*,Oncogenic,Loss-of-function,4,ENST00000276925,NM_004936.3,No,Yes CDKN2B,A23E,Oncogenic,Loss-of-function,4,ENST00000276925,NM_004936.3,No,Yes CDKN2B,P40T,Oncogenic,Loss-of-function,4,ENST00000276925,NM_004936.3,No,Yes KDM5C,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000375401,NM_004187.3,No,Yes KDM5C,D402Y,Likely Oncogenic,Loss-of-function,4,ENST00000375401,NM_004187.3,No,Yes KDM5C,V1075Yfs*2,Likely Oncogenic,Loss-of-function,4,ENST00000375401,NM_004187.3,No,Yes KDM5C,M1_E165del,Likely Oncogenic,Loss-of-function,4,ENST00000375401,NM_004187.3,No,Yes KDM5C,P480L,Likely Oncogenic,Loss-of-function,4,ENST00000375401,NM_004187.3,No,Yes RYBP,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000477973,NM_012234.5,No,Yes SESN2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000253063,NM_031459.4,No,Yes PMS2,R107W,Likely Oncogenic,Loss-of-function,4,ENST00000265849,NM_000535.5,No,Yes PMS2,P470S,Likely Neutral,Likely Neutral,4,ENST00000265849,NM_000535.5,No,Yes PMS2,I668V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000265849,NM_000535.5,No,Yes PMS2,S815L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000265849,NM_000535.5,No,Yes PMS2,R20Q,Oncogenic,Loss-of-function,4,ENST00000265849,NM_000535.5,No,Yes PMS2,S46I,Likely Oncogenic,Loss-of-function,4,ENST00000265849,NM_000535.5,No,Yes PMS2,E5K,Likely Neutral,Likely Neutral,4,ENST00000265849,NM_000535.5,No,Yes PMS2,L585I,Likely Neutral,Likely Neutral,4,ENST00000265849,NM_000535.5,No,Yes PMS2,G857A,Likely Neutral,Likely Neutral,4,ENST00000265849,NM_000535.5,No,Yes PMS2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000265849,NM_000535.5,No,Yes PMS2,I66T,Likely Neutral,Likely Neutral,4,ENST00000265849,NM_000535.5,No,Yes PMS2,E41A,Likely Oncogenic,Loss-of-function,4,ENST00000265849,NM_000535.5,No,Yes PMS2,I18V,Likely Neutral,Likely Neutral,4,ENST00000265849,NM_000535.5,No,Yes PMS2,G207E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000265849,NM_000535.5,No,Yes PMS2,T485K,Likely Neutral,Likely Neutral,4,ENST00000265849,NM_000535.5,No,Yes PMS2,S46N,Likely Oncogenic,Loss-of-function,4,ENST00000265849,NM_000535.5,No,Yes PMS2,K541E,Likely Neutral,Likely Neutral,4,ENST00000265849,NM_000535.5,No,Yes PMS2,H479Q,Likely Neutral,Likely Neutral,4,ENST00000265849,NM_000535.5,No,Yes ZRSR2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000307771,NM_005089.3,No,No SESN3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000536441,NM_144665.3,No,Yes PARP1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000366794,NM_001618.3,No,Yes CDKN2C,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262662,NM_078626.2,No,Yes RAD17,Truncating Mutations,Likely Oncogenic,Loss-of-function,4,ENST00000380774,NM_133339,No,Yes GLI1,R380A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000228682,NM_005269.2,Yes,No NRAS,G12R,Oncogenic,Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,G13C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,Q61R,Oncogenic,Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,Q61E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,G13D,Oncogenic,Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,A59G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,A146T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,A146V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,T58I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,K117D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,K135N,Likely Neutral,Likely Neutral,4,ENST00000369535,NM_002524.4,Yes,No NRAS,G12W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,C51Y,Inconclusive,Inconclusive,4,ENST00000369535,NM_002524.4,Yes,No NRAS,G12C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,G12V,Oncogenic,Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,G13E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,G60E,Likely Oncogenic,Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,A146P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,Q61L,Oncogenic,Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,Q61K,Oncogenic,Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,A59T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,G12D,Oncogenic,Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,G12F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,Wildtype,Likely Neutral,Likely Neutral,4,ENST00000369535,NM_002524.4,Yes,No NRAS,T50I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,E49K,Inconclusive,Inconclusive,4,ENST00000369535,NM_002524.4,Yes,No NRAS,G13R,Oncogenic,Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,Q61H,Oncogenic,Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,G12A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,G12S,Oncogenic,Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No NRAS,G13V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000369535,NM_002524.4,Yes,No MPL,S505N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000372470,NM_005373.2,Yes,No MPL,T119I,Inconclusive,Inconclusive,4,ENST00000372470,NM_005373.2,Yes,No MPL,E230G,Inconclusive,Inconclusive,4,ENST00000372470,NM_005373.2,Yes,No MPL,W515L,Oncogenic,Gain-of-function,4,ENST00000372470,NM_005373.2,Yes,No MPL,W515K,Oncogenic,Gain-of-function,4,ENST00000372470,NM_005373.2,Yes,No MPL,P106L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000372470,NM_005373.2,Yes,No MPL,Exon 10 missense mutations,Likely Oncogenic,Likely Gain-of-function,4,ENST00000372470,NM_005373.2,Yes,No MPL,S204P,Inconclusive,Inconclusive,4,ENST00000372470,NM_005373.2,Yes,No MPL,V285E,Inconclusive,Inconclusive,4,ENST00000372470,NM_005373.2,Yes,No MPL,S204F,Inconclusive,Inconclusive,4,ENST00000372470,NM_005373.2,Yes,No MPL,R321W,Inconclusive,Inconclusive,4,ENST00000372470,NM_005373.2,Yes,No MPL,Y591D,Inconclusive,Inconclusive,4,ENST00000372470,NM_005373.2,Yes,No FLT3,S451E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,F594_R595insGTGSSDNEYFYVDF,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,V592G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,R595_L601dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,D835N,Oncogenic,Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,M737I,Likely Neutral,Likely Neutral,4,ENST00000241453,NM_004119.2,Yes,No FLT3,L601_K602insNVDFREYEYDL,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,N676S,Resistance,Inconclusive,4,ENST00000241453,NM_004119.2,Yes,No FLT3,F691L,Resistance,Inconclusive,4,ENST00000241453,NM_004119.2,Yes,No FLT3,E604_F605insSPRGGNEYFYVDFREYEYDLKWE,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,N676K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,Y597_E598insDEYFYVDFREY,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,M578_E598dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,T167A,Likely Neutral,Likely Neutral,4,ENST00000241453,NM_004119.2,Yes,No FLT3,Y599F,Likely Neutral,Likely Loss-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,S451F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,Internal tandem duplication,Oncogenic,Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,Y842C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,D835del,Oncogenic,Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,F594L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,E598_F612dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,N676D,Resistance,Inconclusive,4,ENST00000241453,NM_004119.2,Yes,No FLT3,Y572C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,V579A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,G831E,Likely Neutral,Likely Neutral,4,ENST00000241453,NM_004119.2,Yes,No FLT3,V194M,Likely Neutral,Likely Neutral,4,ENST00000241453,NM_004119.2,Yes,No FLT3,Y597_E598insAGSSDNEYFYVDFREY,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,A627T,Inconclusive,Inconclusive,4,ENST00000241453,NM_004119.2,Yes,No FLT3,S584_D600dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,M664I,Resistance,Inconclusive,4,ENST00000241453,NM_004119.2,Yes,No FLT3,Y599_E604dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,Y597_K602dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,V557I,Likely Neutral,Likely Neutral,4,ENST00000241453,NM_004119.2,Yes,No FLT3,N841I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,E598_Y599insVAYVDFREYE,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,S584_F605dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,R595_E596insDYVDFR,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,D835A,Oncogenic,Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,D835Y,Oncogenic,Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,K868N,Likely Neutral,Likely Loss-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,F594_D600dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,I867S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,E598_Y599insSGSSDNEYFYVDFREYE,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,I836,Oncogenic,Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,D835E,Oncogenic,Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,Y599_D600insPAPQIMSTSTLISENMNIA,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,D835H,Oncogenic,Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,F612_G613insQGFYVDFREYEYDLKWEFPRENLEF,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,D593_F594insSPEDNEYFYVD,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,D586_E596dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,D839G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,Y364H,Likely Neutral,Likely Neutral,4,ENST00000241453,NM_004119.2,Yes,No FLT3,R834Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,I836del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,V592A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,F590G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,D835V,Oncogenic,Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,D324N,Likely Neutral,Likely Neutral,4,ENST00000241453,NM_004119.2,Yes,No FLT3,Y591D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,S585_F594dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,Y599_D600insEYEYEYEY,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No BTK,R544S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000308731,NM_000061.2,Yes,No BTK,R28P,Likely Neutral,Likely Loss-of-function,4,ENST00000308731,NM_000061.2,Yes,No BTK,T316A,Resistance,Inconclusive,4,ENST00000308731,NM_000061.2,Yes,No BTK,R28C,Likely Neutral,Likely Loss-of-function,4,ENST00000308731,NM_000061.2,Yes,No BTK,G164D,Resistance,Inconclusive,4,ENST00000308731,NM_000061.2,Yes,No BTK,C481G,Inconclusive,Inconclusive,4,ENST00000308731,NM_000061.2,Yes,No BTK,Y551F,Likely Neutral,Loss-of-function,4,ENST00000308731,NM_000061.2,Yes,No BTK,R28S,Inconclusive,Inconclusive,4,ENST00000308731,NM_000061.2,Yes,No BTK,T474S,Resistance,Inconclusive,4,ENST00000308731,NM_000061.2,Yes,No BTK,T474I,Resistance,Inconclusive,4,ENST00000308731,NM_000061.2,Yes,No BTK,C481F,Resistance,Likely Loss-of-function,4,ENST00000308731,NM_000061.2,Yes,No BTK,R28L,Inconclusive,Inconclusive,4,ENST00000308731,NM_000061.2,Yes,No BTK,C481R,Resistance,Likely Loss-of-function,4,ENST00000308731,NM_000061.2,Yes,No BTK,R28H,Likely Neutral,Likely Loss-of-function,4,ENST00000308731,NM_000061.2,Yes,No BTK,C481Y,Resistance,Likely Loss-of-function,4,ENST00000308731,NM_000061.2,Yes,No BTK,C481S,Resistance,Gain-of-function,4,ENST00000308731,NM_000061.2,Yes,No INPPL1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000298229,NM_001567.3,No,Yes CD58,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000369489,NM_001779.2,No,Yes BLM,C1055S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000355112,NM_000057.2,No,Yes BLM,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000355112,NM_000057.2,No,Yes EED,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263360,NM_003797.3,No,Yes FLCN,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000285071,NM_144997.5,No,Yes VAV1,K404R,Likely Neutral,Likely Neutral,4,ENST00000602142,NM_005428.3,Yes,No VAV1,S67Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000602142,NM_005428.3,Yes,No VAV1,Q498K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000602142,NM_005428.3,Yes,No VAV1,R798P,Likely Neutral,Likely Neutral,4,ENST00000602142,NM_005428.3,Yes,No VAV1,E556D,Likely Neutral,Likely Neutral,4,ENST00000602142,NM_005428.3,Yes,No VAV1,M501R,Likely Neutral,Likely Neutral,4,ENST00000602142,NM_005428.3,Yes,No VAV1,E157K,Likely Neutral,Likely Neutral,4,ENST00000602142,NM_005428.3,Yes,No VAV1,H337Y,Likely Neutral,Likely Neutral,4,ENST00000602142,NM_005428.3,Yes,No ABL1,Y440H,Inconclusive,Inconclusive,4,ENST00000318560,NM_005157.4,Yes,No ABL1,M388L,Resistance,Inconclusive,4,ENST00000318560,NM_005157.4,Yes,No ABL1,H396R,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,V379I,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,V289F,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,F311L,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,E355G,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,V299L,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,H396P,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,L248V,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,F317I,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,F317L,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,E355A,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,L384M,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,Y253H,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,D276G,Oncogenic,Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,T315N,Resistance,Inconclusive,4,ENST00000318560,NM_005157.4,Yes,No ABL1,L387M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,F317V,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,E279K,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,E255K,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,T315I,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,Y253F,Resistance,Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,Q252H,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,S417Y,Resistance,Inconclusive,4,ENST00000318560,NM_005157.4,Yes,No ABL1,T315L,Resistance,Inconclusive,4,ENST00000318560,NM_005157.4,Yes,No ABL1,F311I,Resistance,Inconclusive,4,ENST00000318560,NM_005157.4,Yes,No ABL1,T315A,Resistance,Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,G250E,Resistance,Inconclusive,4,ENST00000318560,NM_005157.4,Yes,No ABL1,M351T,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,R332W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,E281K,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,M244V,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,F359V,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,F359I,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,E255V,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,M318T,Inconclusive,Inconclusive,4,ENST00000318560,NM_005157.4,Yes,No ABL1,E459K,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,F317C,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,F359C,Resistance,Likely Gain-of-function,4,ENST00000318560,NM_005157.4,Yes,No ABL1,I293M,Inconclusive,Inconclusive,4,ENST00000318560,NM_005157.4,Yes,No TP53BP1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000382044,NM_001141980.1,No,Yes KBTBD4,R297delinsPRR,Inconclusive,Inconclusive,4,ENST00000395288,NM_016506.5,No,No KBTBD4,P295delinsPP,Inconclusive,Inconclusive,4,ENST00000395288,NM_016506.5,No,No BRCA1,M1628V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,N810Y,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1736G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C24R,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,T1349M,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L52F,Likely Neutral,Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D1778G,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,Q1409L,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,K1110del,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,Q1785H,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D1818G,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E23fs (185delAG),Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M18K,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1775E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,G1738E,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L1407P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1783I,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,A1752G,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R170W,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D1692Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R1751Q,Likely Neutral,Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,I89T,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1101N,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,I21V,Likely Neutral,Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,P1776S,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,Q60L,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,A1752P,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,Y1853*,Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L1780P,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,P142H,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L1844R,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E1682V,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1008I,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R133H,Likely Neutral,Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,P1812S,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,T1852S,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,Y1703H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C197_splice,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,F1695L,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,P1749R,Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1663L,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E1836K,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,I31M,Likely Neutral,Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1378I,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,A1708E,Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V191D,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D1733G,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,K56N,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E362H,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,W1837C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1301R,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,P1859R,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,A1823T,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R1699Q,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D67Y,Likely Neutral,Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1810G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S988A,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C64G,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C39R,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,N132K,Likely Neutral,Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1512I,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,A1843T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,Y1853C,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,G1788V,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D96N,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S186Y,Likely Neutral,Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,P1856S,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R866C,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,A1708V,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,F79S,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1652I,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D1692N,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D1778H,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1804A,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,F1734S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1775R,Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1841R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,G1706E,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D1739E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1809F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L1657P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D1851E,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,Q1826H,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,I1807S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R1751P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R1443G,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1833E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,G1738R,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1838E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E1346K,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R1495K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E1282V,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,G57R,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,K45N,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,W1718S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1542C,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,W1782C,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R841Q,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1841N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,Q1756fs,Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R1589P,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E1794D,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,T1685I,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1775V,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E1214K,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,Y1703S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1722F,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,I15T,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,I124V,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1497A,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,I42V,Likely Neutral,Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,F1761I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1808A,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1689R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,F1734L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D1739Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C47F,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M18T,Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,P798L,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,A1830T,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,G1743R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R1699W,Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1411T,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C1697R,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1775K,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D1344H,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1809A,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,K50L,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S59R,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,G1803A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R71G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,N1647K,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L28P,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V271L,Likely Neutral,Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,Q1811R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C24Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C27A,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1652K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1651P,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,I1766S,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,Q12Y,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1652T,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E29V,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1400V,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L165P,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,I68K,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,T37R,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C39S,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E143K,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S153R,Likely Neutral,Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L1564P,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,K1793N,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,H1686Q,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D1778Y,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,H1283Y,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V191I,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S4F,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,P1812R,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,W1837R,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,W1718L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1714G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C1787S,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C360R,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,F1662S,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,H1746Q,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,P1856T,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,T1691K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E1682K,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1741G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1473P,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,T77M,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1164I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D245V,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,Q1756C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1663K,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L63F,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1613C,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,K45T,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,T1700A,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1628T,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1696L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,T1773I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D1778N,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,G1656D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1713A,Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,P1771R,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1783L,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C44Y,Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,G1706A,Likely Neutral,Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L1267S,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,K1702E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C47G,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,N1819Y,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,T1685A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,N550H,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E1660G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,F1704S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L1764P,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,T1691I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,F1761S,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E1644G,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1486C,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,W1718C,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,T1720I,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C39Y,Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R496C,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1655F,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1715C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1448G,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1665M,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C1767S,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D1546N,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,N1236K,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,A1669S,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,H1402Y,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1297del,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,T826K,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1689T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,P1637L,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L22S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R1753K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,A1789S,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E1586G,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,Y856H,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,H1421Y,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,K50E,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L1705P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1833M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R170Q,Likely Neutral,Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,P1806A,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,P1812A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,H1746N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,T1773S,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,N1730S,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,Y179C,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E1060A,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E33A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,N1819S,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,I26N,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,M1783T,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V11A,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L1664P,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,I90T,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L246V,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C61G,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,Y105C,Likely Neutral,Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D1739V,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,A1789T,Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S308A,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D695N,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L147F,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,P1771L,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R1589H,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R841W,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,H1805P,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1715R,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,P1614S,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,H1686R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,A1843P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,K45Q,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R1699L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R1758G,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1653M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1688del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L358R,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,H41R,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S72R,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1841A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,K38N,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1736A,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D1739G,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1651F,Likely Neutral,Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R1753T,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,G1770V,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,A1752V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R1835P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1613G,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,W1837G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,H1862L,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E1735K,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1715N,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L82P,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,E1250K,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1534M,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,T231M,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,K1487R,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S1140G,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L668F,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,K65M,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,D1692H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,R1726G,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,L1854P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,N473S,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,V1804D,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,T1720A,Likely Neutral,Likely Neutral,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,C44F,Likely Oncogenic,Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,G1763V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,I89N,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,S4P,Inconclusive,Inconclusive,4,ENST00000357654,NM_007294.3,No,Yes BRCA1,G1788D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357654,NM_007294.3,No,Yes LRP1B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000389484,NM_018557,No,Yes LRP1B,R1661H,Inconclusive,Inconclusive,4,ENST00000389484,NM_018557,No,Yes MED12,G44D,Oncogenic,Likely Loss-of-function,4,ENST00000374080,NM_005120.2,Yes,Yes MED12,Exon 2 mutations,Oncogenic,Likely Loss-of-function,4,ENST00000374080,NM_005120.2,Yes,Yes MED12,L1224F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000374080,NM_005120.2,Yes,Yes MED12,G44S,Oncogenic,Likely Loss-of-function,4,ENST00000374080,NM_005120.2,Yes,Yes MED12,Exon 1 mutations,Oncogenic,Likely Loss-of-function,4,ENST00000374080,NM_005120.2,Yes,Yes MED12,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000374080,NM_005120.2,Yes,Yes CXCR4,S330_S352fs,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241393,NM_003467.2,Yes,No CXCR4,G332_S352trunc,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241393,NM_003467.2,Yes,No CXCR4,R334*,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241393,NM_003467.2,Yes,No CXCR4,S338*,Oncogenic,Gain-of-function,4,ENST00000241393,NM_003467.2,Yes,No BRAF,K601Q,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,S607F,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,N486_T491del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,E586K,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,N581Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G466V,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,N581S,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,A33T,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,T529I,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,R558Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,N581D,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G596S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,A728V,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,D594V,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G478C,Likely Neutral,Loss-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,S122Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,V600K,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,E501K,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,T599insTT,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,p61BRAF-V600E,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,D594N,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,L597P,Resistance,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,L597Q,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,S467L,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,R682W,Resistance,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,N486_T488del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,Q257R,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G596C,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,F247L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,L485_P490del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,A598T,Likely Neutral,Loss-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,R271H,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,D287H,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,V487_P490del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,S363F,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,A598V,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,T599R,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,S151A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G466R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G466A,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,K483E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,V600D,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,K499E,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,T274A,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,P490_Q494del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,R462I,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,T599dup,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,W531C,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,M117L,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,R671Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,A489_P490del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,W604C,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,T310I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,L505H,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,T488_P492del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,K601E,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,L597R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,V600E,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,D594G,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,M620I,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,E451K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,Y472C,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,N412S,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,D594Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,L485_Q494del,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,T488_P490del,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,R239Q,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,N581I,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,N486del,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,V471F,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,S467A,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,F595L,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,V600R,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,L597S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,I592_A598dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G469V,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,N486_P490del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,V600A,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,I463S,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,V600L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,A762V,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G469L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,N486_T491delinsK,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G596R,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,V487_P492delinsA,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,H725Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,E501G,Likely Neutral,Likely Loss-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,T599I,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,N581T,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,A598_T599insV,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G466E,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,R389C,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,V600M,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,E275K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,N486_A489del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,Q201H,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,R506_K507insVLR,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,I572F,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,L597V,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,V600G,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G464V,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G469E,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,I326V,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,T599_V600insV,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,L584F,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G469A,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,M517V,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,N486_V487del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,D594A,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,V600_K601insDFGLAT,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,V459L,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,P162S,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,T241P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,D594H,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,L514V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,S616Y,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,A246P,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G464R,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,K601T,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,P367S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,W450L,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,F468C,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,Kinase Domain Duplication,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,T529N,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G596D,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,R462E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,H574Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,R239L,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G469R,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,K601N,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,L485F,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,P490del,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G469del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G596V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,P367R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G469S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,K483M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,F294L,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,T529M,Likely Neutral,Likely Neutral,4,ENST00000288602,NM_004333.4,Yes,No BRAF,R509H,Likely Neutral,Loss-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,L485_P490delinsF,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,V600delinsYM,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,L485Y,Resistance,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G464E,Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,G606W,Likely Neutral,Likely Loss-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,L485W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,D594E,Likely Oncogenic,Gain-of-function,4,ENST00000288602,NM_004333.4,Yes,No BRAF,L485_P490delinsY,Inconclusive,Inconclusive,4,ENST00000288602,NM_004333.4,Yes,No MYD88,S230N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396334,NM_002468.4,Yes,No MYD88,M232T,Oncogenic,Gain-of-function,4,ENST00000396334,NM_002468.4,Yes,No MYD88,L252P,Oncogenic,Gain-of-function,4,ENST00000396334,NM_002468.4,Yes,No MYD88,S243N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000396334,NM_002468.4,Yes,No MYD88,M219T,Oncogenic,Gain-of-function,4,ENST00000396334,NM_002468.4,Yes,No MYD88,L265P,Oncogenic,Gain-of-function,4,ENST00000396334,NM_002468.4,Yes,No MYD88,Oncogenic Mutations,Oncogenic,Gain-of-function,4,ENST00000396334,NM_002468.4,Yes,No PALB2,T1030I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000261584,NM_024675.3,No,Yes PALB2,K30N,Likely Neutral,Likely Neutral,4,ENST00000261584,NM_024675.3,No,Yes PALB2,Y28C,Likely Oncogenic,Loss-of-function,4,ENST00000261584,NM_024675.3,No,Yes PALB2,L939W,Inconclusive,Inconclusive,4,ENST00000261584,NM_024675.3,No,Yes PALB2,R37H,Likely Neutral,Likely Neutral,4,ENST00000261584,NM_024675.3,No,Yes PALB2,K18R,Likely Neutral,Likely Neutral,4,ENST00000261584,NM_024675.3,No,Yes PALB2,L35P,Likely Oncogenic,Loss-of-function,4,ENST00000261584,NM_024675.3,No,Yes PALB2,L1143P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000261584,NM_024675.3,No,Yes PALB2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000261584,NM_024675.3,No,Yes PALB2,N241D,Inconclusive,Inconclusive,4,ENST00000261584,NM_024675.3,No,Yes ACTG1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000331925,NM_001199954.1,No,Yes BCORL1,Q1076H,Inconclusive,Inconclusive,3,ENST00000218147,,No,Yes BCORL1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,3,ENST00000218147,,No,Yes SMARCA4,A1186T,Likely Neutral,Likely Neutral,4,ENST00000358026,NM_001128849.1,No,Yes SMARCA4,R1192C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358026,NM_001128849.1,No,Yes SMARCA4,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358026,NM_001128849.1,No,Yes SMARCA4,E1083G,Likely Oncogenic,Loss-of-function,4,ENST00000358026,NM_001128849.1,No,Yes SMARCA4,R1243W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358026,NM_001128849.1,No,Yes SMARCA4,G1232D,Likely Oncogenic,Loss-of-function,4,ENST00000358026,NM_001128849.1,No,Yes SMARCA4,R1135W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358026,NM_001128849.1,No,Yes SMARCA4,R978*,Oncogenic,Loss-of-function,4,ENST00000358026,NM_001128849.1,No,Yes SMARCA4,G1232S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358026,NM_001128849.1,No,Yes SMARCA4,G1162C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358026,NM_001128849.1,No,Yes SMARCA4,E821K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358026,NM_001128849.1,No,Yes SMARCA4,T910M,Likely Oncogenic,Loss-of-function,4,ENST00000358026,NM_001128849.1,No,Yes SMARCA4,R1093*,Oncogenic,Loss-of-function,4,ENST00000358026,NM_001128849.1,No,Yes SMARCA4,R1189*,Likely Oncogenic,Loss-of-function,4,ENST00000358026,NM_001128849.1,No,Yes SMARCA4,R1189Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358026,NM_001128849.1,No,Yes SMARCA4,K785R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358026,NM_001128849.1,No,Yes SMARCA4,E882K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358026,NM_001128849.1,No,Yes CDKN2A,M53I,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,A57V,Likely Neutral,Likely Neutral,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,A60V,Likely Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,I49S,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,H83Y,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,Q50P,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,L32P,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,E69G,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,D108N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,G35R,Likely Neutral,Likely Neutral,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,Q50R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,N71S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,R87L,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,P81L,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,D153H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,A36P,Likely Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,D84Y,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,G23D,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,A68T,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,G35A,Likely Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,H83N,Likely Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,Q50*,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,N71K,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,R87W,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,G67R,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,D84G,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,P114S,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,G35V,Likely Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,D74Y,Likely Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,S56I,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,D108V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,T77P,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,G67S,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,L16P,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,P48L,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,D84V,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,A148T,Inconclusive,Inconclusive,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,N71I,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,L63P,Inconclusive,Inconclusive,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,R87P,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,D84N,Likely Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,Q50H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,G101W,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,D108G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,V59G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,P81T,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,D108Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,E88K,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,D84H,Likely Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,P114L,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,D108H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,R112G,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,D74N,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,R24P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,A60R,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes CDKN2A,R99P,Oncogenic,Loss-of-function,4,ENST00000304494,NM_000077.4,No,Yes DNMT3B,DNMT3B7,Likely Oncogenic,Likely Loss-of-function,4,ENST00000328111,NM_006892.3,No,Yes DNMT3B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000328111,NM_006892.3,No,Yes ETV6,R369Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000396373,NM_001987.4,No,Yes ETV6,P214L,Likely Oncogenic,Loss-of-function,4,ENST00000396373,NM_001987.4,No,Yes ETV6,R418G,Likely Oncogenic,Loss-of-function,4,ENST00000396373,NM_001987.4,No,Yes ETV6,R369W,Inconclusive,Inconclusive,4,ENST00000396373,NM_001987.4,No,Yes ETV6,N385_R418del,Likely Oncogenic,Loss-of-function,4,ENST00000396373,NM_001987.4,No,Yes NUP93,E14K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000308159,NM_014669.4,No,No NUP93,Y629C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000308159,NM_014669.4,No,No NUP93,K442Nfs*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000308159,NM_014669.4,No,No NUP93,G591V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000308159,NM_014669.4,No,No NUP93,Exon 13 deletion,Likely Oncogenic,Likely Loss-of-function,4,ENST00000308159,NM_014669.4,No,No NPM1,W288fs,Likely Oncogenic,Likely Loss-of-function,4,ENST00000296930,NM_002520.6,No,Yes NPM1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000296930,NM_002520.6,No,Yes SOX9,K398A,Likely Oncogenic,Gain-of-function,4,ENST00000245479,NM_000346.3,Yes,Yes SOX9,L142P,Likely Oncogenic,Loss-of-function,4,ENST00000245479,NM_000346.3,Yes,Yes SOX9,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000245479,NM_000346.3,Yes,Yes SOX9,P70R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000245479,NM_000346.3,Yes,Yes APC,R640G,Oncogenic,Loss-of-function,4,ENST00000257430,NM_000038.5,No,Yes APC,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000257430,NM_000038.5,No,Yes APC,I1307K,Inconclusive,Inconclusive,4,ENST00000257430,NM_000038.5,No,Yes APC,N1026S,Likely Oncogenic,Loss-of-function,4,ENST00000257430,NM_000038.5,No,Yes PMS1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000441310,NM_000534.4,No,Yes PMS1,Q233*,Likely Oncogenic,Loss-of-function,4,ENST00000441310,NM_000534.4,No,Yes BCL2L11,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000393256,NM_138621.4,No,Yes BCL2L11,Single Nucleotide Polymorphism,Oncogenic,Loss-of-function,4,ENST00000393256,NM_138621.4,No,Yes EPHA7,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000369303,NM_004440.3,Yes,Yes SESN1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000436639,NM_014454.2,No,Yes CIC,A1185T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,R202Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,R215W,Likely Oncogenic,Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,A281S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,R666C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,Q247R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,R202W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,S649F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,G107E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,R181W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,G1098D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,R1515H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,P722L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,R201W,Likely Oncogenic,Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,Q1516H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,R1515C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes CIC,R1515L,Likely Oncogenic,Loss-of-function,4,ENST00000575354,NM_015125.3,No,Yes MAP2K4,P326L,Likely Oncogenic,Loss-of-function,4,ENST00000353533,NM_003010.3,No,Yes MAP2K4,V321M,Likely Oncogenic,Loss-of-function,4,ENST00000353533,NM_003010.3,No,Yes MAP2K4,R134W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000353533,NM_003010.3,No,Yes MAP2K4,G85R,Oncogenic,Loss-of-function,4,ENST00000353533,NM_003010.3,No,Yes MAP2K4,A279T,Oncogenic,Loss-of-function,4,ENST00000353533,NM_003010.3,No,Yes MAP2K4,N234I,Oncogenic,Loss-of-function,4,ENST00000353533,NM_003010.3,No,Yes MAP2K4,R228K,Oncogenic,Loss-of-function,4,ENST00000353533,NM_003010.3,No,Yes MAP2K4,R154W,Oncogenic,Loss-of-function,4,ENST00000353533,NM_003010.3,No,Yes MAP2K4,S251N,Oncogenic,Loss-of-function,4,ENST00000353533,NM_003010.3,No,Yes MAP2K4,R304*,Likely Oncogenic,Loss-of-function,4,ENST00000353533,NM_003010.3,No,Yes MAP2K4,R134Q,Likely Neutral,Likely Neutral,4,ENST00000353533,NM_003010.3,No,Yes MAP2K4,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000353533,NM_003010.3,No,Yes DKK1,F234K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373970,NM_012242.2,No,No DKK1,W206E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373970,NM_012242.2,No,No DKK1,E232K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373970,NM_012242.2,No,No DKK1,H229E,Likely Neutral,Likely Neutral,4,ENST00000373970,NM_012242.2,No,No DKK1,K226E,Likely Neutral,Likely Neutral,4,ENST00000373970,NM_012242.2,No,No SHQ1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000325599,NM_018130.2,No,Yes RBM10,V419E,Oncogenic,Loss-of-function,4,ENST00000329236,NM_001204468.1,No,Yes RBM10,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000329236,NM_001204468.1,No,Yes AR,H875Y,Oncogenic,Gain-of-function,4,ENST00000374690,NM_000044.3,Yes,No AR,AR-V7,Oncogenic,Gain-of-function,4,ENST00000374690,NM_000044.3,Yes,No AR,L702H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000374690,NM_000044.3,Yes,No AR,Q120E,Likely Neutral,Likely Neutral,4,ENST00000374690,NM_000044.3,Yes,No AR,L272F,Likely Neutral,Likely Neutral,4,ENST00000374690,NM_000044.3,Yes,No AR,L57Q,Likely Neutral,Loss-of-function,4,ENST00000374690,NM_000044.3,Yes,No AR,N235K,Likely Neutral,Likely Loss-of-function,4,ENST00000374690,NM_000044.3,Yes,No AR,ARv567es,Oncogenic,Gain-of-function,4,ENST00000374690,NM_000044.3,Yes,No AR,A159T,Inconclusive,Inconclusive,4,ENST00000374690,NM_000044.3,Yes,No AR,W742L,Oncogenic,Gain-of-function,4,ENST00000374690,NM_000044.3,Yes,No AR,T878S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000374690,NM_000044.3,Yes,No AR,Q58_Q59insL,Likely Neutral,Likely Loss-of-function,4,ENST00000374690,NM_000044.3,Yes,No AR,F876L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000374690,NM_000044.3,Yes,No AR,L57del,Likely Neutral,Likely Neutral,4,ENST00000374690,NM_000044.3,Yes,No AR,F877L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000374690,NM_000044.3,Yes,No AR,P380R,Inconclusive,Inconclusive,4,ENST00000374690,NM_000044.3,Yes,No AR,G216R,Likely Neutral,Likely Neutral,4,ENST00000374690,NM_000044.3,Yes,No AR,T878A,Oncogenic,Gain-of-function,4,ENST00000374690,NM_000044.3,Yes,No AR,W742C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000374690,NM_000044.3,Yes,No AR,G248V,Inconclusive,Inconclusive,4,ENST00000374690,NM_000044.3,Yes,No ERBB4,T926M,Likely Neutral,Neutral,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,N181S,Likely Neutral,Neutral,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,E452K,Oncogenic,Gain-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,G936R,Inconclusive,Inconclusive,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,R1275W,Likely Neutral,Loss-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,S303F,Inconclusive,Inconclusive,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,R393W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,S303Y,Inconclusive,Inconclusive,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,R544W,Oncogenic,Gain-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,E542K,Oncogenic,Gain-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,D931Y,Likely Oncogenic,Gain-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,K935I,Oncogenic,Gain-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,Y285C,Oncogenic,Gain-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,R306S,Likely Oncogenic,Gain-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,D595V,Oncogenic,Gain-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,E836K,Oncogenic,Gain-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,T244R,Likely Neutral,Neutral,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,S774G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,H618P,Likely Neutral,Neutral,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,R106H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,D843N,Likely Neutral,Loss-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,E872K,Oncogenic,Gain-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,L798R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,E563K,Oncogenic,Gain-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,E317K,Oncogenic,Gain-of-function,4,ENST00000342788,NM_005235.2,Yes,No ERBB4,V348L,Likely Neutral,Neutral,4,ENST00000342788,NM_005235.2,Yes,No FOXL2,C134W,Likely Oncogenic,Loss-of-function,4,ENST00000330315,NM_023067.3,Yes,Yes FOXL2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000330315,NM_023067.3,Yes,Yes WT1,H445Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000332351,NM_024426.4,Yes,Yes WT1,R462W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000332351,NM_024426.4,Yes,Yes WT1,S341A,Likely Neutral,Likely Neutral,4,ENST00000332351,NM_024426.4,Yes,Yes WT1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000332351,NM_024426.4,Yes,Yes WT1,D464N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000332351,NM_024426.4,Yes,Yes WT1,F222S,Likely Neutral,Likely Neutral,4,ENST00000332351,NM_024426.4,Yes,Yes ATP6V1B2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000276390,NM_001693.3,No,Yes ATP6V1B2,R400Q,Oncogenic,Loss-of-function,4,ENST00000276390,NM_001693.3,No,Yes ATP6V1B2,Y371C,Oncogenic,Loss-of-function,4,ENST00000276390,NM_001693.3,No,Yes NTRK3,G608S,Likely Neutral,Likely Neutral,4,ENST00000360948,NM_001012338.2,Yes,No NTRK3,G623R,Resistance,Inconclusive,4,ENST00000360948,NM_001012338.2,Yes,No NTRK3,G696A,Resistance,Inconclusive,4,ENST00000360948,NM_001012338.2,Yes,No NTRK3,F617L,Resistance,Inconclusive,4,ENST00000360948,NM_001012338.2,Yes,No CARM1,S216A,Inconclusive,Likely Loss-of-function,4,ENST00000327064,NM_199141.1,No,No CARM1,S216C,Inconclusive,Inconclusive,4,ENST00000327064,NM_199141.1,No,No CARM1,S216E,Inconclusive,Inconclusive,4,ENST00000327064,NM_199141.1,No,No CARM1,S216T,Inconclusive,Inconclusive,4,ENST00000327064,NM_199141.1,No,No AXIN1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262320,NM_003502.3,No,Yes RNF43,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000407977,NM_017763.4,No,Yes BMPR1A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000372037,NM_004329.2,No,Yes NFE2,R273W,Inconclusive,Inconclusive,4,ENST00000312156,NM_001136023.2,Yes,No NFE2,R284H,Likely Neutral,Likely Loss-of-function,4,ENST00000312156,NM_001136023.2,Yes,No NFE2,R272Q,Inconclusive,Inconclusive,4,ENST00000312156,NM_001136023.2,Yes,No NFE2,C283R,Likely Neutral,Likely Loss-of-function,4,ENST00000312156,NM_001136023.2,Yes,No NFE2,K287R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000312156,NM_001136023.2,Yes,No NFE2,Truncating Mutations,Likely Oncogenic,Likely Gain-of-function,4,ENST00000312156,NM_001136023.2,Yes,No NFE2,R219Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000312156,NM_001136023.2,Yes,No NFE2,Q7Tfs*,Likely Oncogenic,Likely Gain-of-function,4,ENST00000312156,NM_001136023.2,Yes,No SDHAF2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000301761,NM_017841.2,No,Yes SPOP,W131C,Likely Neutral,Likely Neutral,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,N296I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,F102V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,R121Q,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,Y87C,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,W131G,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,S119N,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,E50K,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,F133C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,F133L,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,P94A,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,D130A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,F125V,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,Y87N,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,K129E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,F102C,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,F133V,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,W131A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,W131R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,G75R,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,K134N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,M117V,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,E47K,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,M117I,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,S80R,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,D140G,Likely Oncogenic,Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes SPOP,F102I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000347630,NM_001007228.1,No,Yes FOXA1,S453fs*,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,F266L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,S250F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,P358fs,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,H247Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,R219S,Likely Oncogenic,Likely Switch-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,M253_N256del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,L388M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,I360*,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,M253K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,F266S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,Y259S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,G87R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,R265_Q271del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,I176M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,F254_E255del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,P359fs,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,L455M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,Y259C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,H247R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,D226N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,H247Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,R219C,Likely Oncogenic,Likely Switch-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,F400I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,R261C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,R261G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000250448,NM_004496.3,Yes,Yes FBXO11,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000403359,NM_001190274.1,No,Yes ARID3A,Y330A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263620,NM_005224.2,No,Yes ARID3A,F317A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263620,NM_005224.2,No,Yes ARID3A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263620,NM_005224.2,No,Yes ARID3A,W299A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263620,NM_005224.2,No,Yes ARID3A,P268A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263620,NM_005224.2,No,Yes PBRM1,D1308Gfs*,Oncogenic,Loss-of-function,4,ENST00000394830,NM_018313.4,No,Yes PBRM1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000394830,NM_018313.4,No,Yes MERTK,R758C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000295408,NM_006343.2,Yes,No MERTK,R758H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000295408,NM_006343.2,Yes,No MERTK,Y754F,Likely Neutral,Likely Loss-of-function,4,ENST00000295408,NM_006343.2,Yes,No MAP2K1,I111_I112del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,S86A,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,D152_L155del,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,S222D,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,K104_P105del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,N109_Q110del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,P323A,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,N382H,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E320K,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,I111A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,I107_R108del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,R227K,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E114V,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,Q56P,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,P105_I107delinsS,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,Q58_E62del,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,I99_H100del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,R96K,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,T55P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,H119Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,A257V,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,Q58H,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E102_I103del,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,D336H,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L253V,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,H119P,Resistance,Inconclusive,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,F53_Q58delinsL,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,V60M,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L42_K57del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L332V,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L98_I99del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,P264R,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,D67N,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,Q56_V60del,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E41_L54del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,F129L,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,G213V,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,I111R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,P193S,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,P105_I107del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,R49L,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,K97_L98del,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,A132V,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,S123P,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E203V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L101_E102del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,S123T,Inconclusive,Inconclusive,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L63M,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,F53L,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L313F,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,H100_I103delinsPL,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,Y130H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,R201H,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,I204T,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E203R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,R108Q,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,I111N,Resistance,Inconclusive,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E163K,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,P321H,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E51_Q58del,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,Q56_G61delinsR,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,P387S,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,H100_L101del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E144K,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,P162F,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,P105_A106del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,P264S,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,R113_E114del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,G128V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L98_I103delinsES,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,R201C,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,A95_R96del,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L177M,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,R47Q,Inconclusive,Inconclusive,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,V258I,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,P124Q,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,S327T,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,V154I,Inconclusive,Inconclusive,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,K57N,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,P124L,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,K59del,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E203D,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,T28I,Inconclusive,Inconclusive,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,F53C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E333A,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,Y130C,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,V60E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E41_F53del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,G128D,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,F53I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,I103_K104del,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,N122D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,N109_R113del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,Y130N,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,G176V,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E203Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,D16N,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E44K,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,H119Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,V211D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,K57T,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,I103M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,F53S,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,K57_G61del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L42F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L115R,Resistance,Inconclusive,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,R201D,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L37P,Inconclusive,Inconclusive,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,P124S,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E120Q,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E203K,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,A106_I107del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E114_L115del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,G210E,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,R96_K97del,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L177V,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,R108_N109del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,R201_E203delinsQ,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L206F,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,E44G,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,R349K,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,A52V,Likely Neutral,Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,K97M,Likely Neutral,Loss-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,Q110_I111del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,I103N,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,M146T,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,I99_K104del,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,P306H,Inconclusive,Inconclusive,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,C121S,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,I310L,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,K57_V60delinsN,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,P124R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,F53_Q58del,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,R49H,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,S218D,Likely Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,I111P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,M146I,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L98_K104delinsQ,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,I112_R113del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,M146L,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,I204F,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,P105_I107delinsL,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,K35N,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,G328E,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L50_E51insI,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,G294R,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,A106T,Likely Neutral,Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,F53V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,R291M,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,K57E,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L115P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,D65N,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L235H,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L98_I103del,Oncogenic,Gain-of-function,4,ENST00000307102,NM_002755.3,Yes,No MAP2K1,R289Q,Likely Neutral,Likely Neutral,4,ENST00000307102,NM_002755.3,Yes,No EPHA3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000336596,NM_005233.5,No,Yes VHL,D121G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,H191D,Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,S65P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,P81L,Inconclusive,Inconclusive,4,ENST00000256474,NM_000551.3,No,Yes VHL,R161Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,H115R,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,L188V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,L158V,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,Y112D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,N150K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,L63P,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,Y98H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,L158Q,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,Y112H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,S111R,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,E70K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,N78S,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,V155A,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,L128F,Likely Neutral,Likely Neutral,4,ENST00000256474,NM_000551.3,No,Yes VHL,S111C,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,I151S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,S68W,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,R64P,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,R200W,Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,Q164R,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,G114R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,L89H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,L118R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,P40fs*,Inconclusive,Inconclusive,4,ENST00000256474,NM_000551.3,No,Yes VHL,F119S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,L158P,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,L188Q,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,S65W,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,W117L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,Y98N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,H115Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,L118P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,V84L,Inconclusive,Inconclusive,4,ENST00000256474,NM_000551.3,No,Yes VHL,S65L,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,Q145H,Likely Neutral,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,R167Q,Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,Y112C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,N90I,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,A149P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,R69C,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,W117C,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,F76del,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,C162F,Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,R167W,Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,Q96P,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,S65A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,R82P,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes VHL,P86H,Likely Oncogenic,Loss-of-function,4,ENST00000256474,NM_000551.3,No,Yes BCL10,R58Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000370580,NM_003921.4,No,Yes BCL10,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000370580,NM_003921.4,No,Yes BCL10,E140*,Likely Oncogenic,Likely Gain-of-function,4,ENST00000370580,NM_003921.4,No,Yes RAD54L,G325R,Likely Oncogenic,Loss-of-function,4,ENST00000371975,NM_001142548.1,No,No ARID2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000334344,NM_152641.2,No,Yes KEAP1,C249Y,Likely Oncogenic,Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,R320Q,Oncogenic,Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,R204P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,D479G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,D422N,Oncogenic,Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,G186R,Oncogenic,Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,S102L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,R470H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,V155F,Oncogenic,Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,G333C,Oncogenic,Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,R601W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,R415G,Oncogenic,Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,G524C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,P278S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,R470C,Oncogenic,Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,G430C,Oncogenic,Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,G379D,Likely Oncogenic,Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,G423V,Oncogenic,Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,D389Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,E611D,Likely Neutral,Likely Neutral,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,S243C,Oncogenic,Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,E117K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,R470S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,C23Y,Likely Oncogenic,Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,S338L,Likely Oncogenic,Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,G417R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,G480W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,T142M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,L268P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,G603W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,S144F,Likely Neutral,Likely Neutral,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,G333S,Oncogenic,Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes KEAP1,R272C,Oncogenic,Loss-of-function,4,ENST00000171111,NM_203500.1,No,Yes CDC73,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000367435,NM_024529.4,No,Yes NTRK2,M713I,Likely Neutral,Likely Loss-of-function,4,ENST00000277120,NM_006180.3,Yes,No NTRK2,R734C,Likely Neutral,Likely Loss-of-function,4,ENST00000277120,NM_006180.3,Yes,No NTRK2,R715G,Likely Neutral,Likely Neutral,4,ENST00000277120,NM_006180.3,Yes,No SRSF2,S54F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000359995,NM_003016.4,No,No SRSF2,S54A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000359995,NM_003016.4,No,No SRSF2,P95L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000359995,NM_003016.4,No,No SRSF2,P107H,Likely Neutral,Likely Neutral,4,ENST00000359995,NM_003016.4,No,No SRSF2,P95_R102del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000359995,NM_003016.4,No,No SRSF2,H99L,Likely Neutral,Likely Neutral,4,ENST00000359995,NM_003016.4,No,No SRSF2,R94_P95insR,Likely Oncogenic,Likely Loss-of-function,4,ENST00000359995,NM_003016.4,No,No SRSF2,P95H,Oncogenic,Loss-of-function,4,ENST00000359995,NM_003016.4,No,No SRSF2,R102del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000359995,NM_003016.4,No,No SRSF2,R86_G93dup,Likely Oncogenic,Likely Loss-of-function,4,ENST00000359995,NM_003016.4,No,No SRSF2,P95R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000359995,NM_003016.4,No,No PPM1D,422_605trunc,Likely Oncogenic,Likely Gain-of-function,4,ENST00000305921,NM_003620.3,Yes,No AXIN2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000307078,NM_004655.3,No,Yes MYOD1,L122R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000250003,NM_002478.4,No,Yes AJUBA,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262713,NM_032876.5,No,Yes CTR9,R98W,Likely Neutral,Likely Neutral,4,ENST00000361367,NM_014633.4,No,Yes CTR9,P164S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000361367,NM_014633.4,No,Yes CTR9,R201C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000361367,NM_014633.4,No,Yes CTR9,A220T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000361367,NM_014633.4,No,Yes NKX2-1,A369V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000354822,NM_001079668.2,Yes,No TP63,R379C,Inconclusive,Inconclusive,4,ENST00000264731,NM_003722.4,Yes,Yes TP63,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264731,NM_003722.4,Yes,Yes CASP8,G384A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000358485,NM_001080125.1,No,Yes CASP8,Promoter Hypermethylation,Likely Oncogenic,Loss-of-function,4,ENST00000358485,NM_001080125.1,No,Yes CASP8,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358485,NM_001080125.1,No,Yes CASP8,R307W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358485,NM_001080125.1,No,Yes MYCN,P44L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000281043,NM_005378.4,Yes,No ERBB3,V104M,Oncogenic,Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,R103G,Inconclusive,Inconclusive,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,K329E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,D297H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,R669C,Inconclusive,Inconclusive,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,K329T,Likely Neutral,Likely Neutral,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,P262H,Oncogenic,Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,S846I,Oncogenic,Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,R475W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,N126K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,T389K,Oncogenic,Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,A1131T,Inconclusive,Inconclusive,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,A232T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,T355I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,A232V,Oncogenic,Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,Q809R,Oncogenic,Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,E928G,Oncogenic,Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,V714M,Likely Neutral,Likely Neutral,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,V104L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,D297Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,G284R,Oncogenic,Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No ERBB3,M91I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000267101,NM_001982.3,Yes,No EP400,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000389561,NM_015409.3,No,Yes PTEN,R173H,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,A126S,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,H61D,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,R130L,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,A126P,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,K289E,Inconclusive,Inconclusive,4,ENST00000371953,NM_000314.4,No,Yes PTEN,V369G,Likely Neutral,Neutral,4,ENST00000371953,NM_000314.4,No,Yes PTEN,I122S,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,L181P,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,R335L,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,P95L,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Y155H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,F341V,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G129V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,N48K,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,A126V,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Y138L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,T160I,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,P169H,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,N276S,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,V133I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,L112R,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G127R,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,H93Y,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,H93D,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,I122V,Likely Neutral,Neutral,4,ENST00000371953,NM_000314.4,No,Yes PTEN,I101F,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,W111G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,T167A,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D92V,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G44D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G251V,Likely Neutral,Likely Neutral,4,ENST00000371953,NM_000314.4,No,Yes PTEN,K128N,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,R130P,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,H123D,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,K6I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,C124N,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,H123Q,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G165E,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,C124S,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,A121V,Likely Neutral,Neutral,4,ENST00000371953,NM_000314.4,No,Yes PTEN,H61R,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G129E,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,R15S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Q171E,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,K125E,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,K125L,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,R173P,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,I168F,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,K6E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Y174N,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,M199del,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,S10N,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,T319A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D92G,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,R173C,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Y177D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D252G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,P38F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,V343E,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,H93L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,T277A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,C105F,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D162H,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,A121P,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,M134L,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,T401I,Likely Neutral,Likely Neutral,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D24Y,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,N94I,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G127N,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,R130G,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Y155C,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G251C,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,E157G,Inconclusive,Inconclusive,4,ENST00000371953,NM_000314.4,No,Yes PTEN,R130K,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G132V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,F154L,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,K128Q,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D107V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,T167N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D331G,Inconclusive,Inconclusive,4,ENST00000371953,NM_000314.4,No,Yes PTEN,K125R,Likely Neutral,Neutral,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D107Y,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G127E,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D92A,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,L320S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,M134I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D92H,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,I122L,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,L23F,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,P38H,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,H118P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,L108P,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,F347L,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,F241S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,H123Y,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G251D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G129A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,S170I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,I67K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,C71Y,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,T131S,Likely Neutral,Neutral,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D92E,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,T319del,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,H93Q,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G36R,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,T131A,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,L345Q,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,L42R,Inconclusive,Inconclusive,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Q110R,Likely Neutral,Likely Neutral,4,ENST00000371953,NM_000314.4,No,Yes PTEN,P246L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Y68H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,S227F,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,P95S,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,H93P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,R159G,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,P96Q,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,A34D,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,A121E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Y65C,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,R15K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,T277N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,A151P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,R130*,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G132S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,V255A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Y177C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,C136R,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G165R,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Y27S,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,R161G,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,P38L,Inconclusive,Inconclusive,4,ENST00000371953,NM_000314.4,No,Yes PTEN,F21A,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,C124R,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G129R,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,H93R,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,K128R,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,T131L,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,C124G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,K125M,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G129D,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,W111S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D326N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Y68N,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,C136Y,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,V217D,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D301N,Likely Neutral,Likely Neutral,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D92Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,M35R,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G132D,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,K128T,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Y16C,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G165V,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,R130A,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,R335*,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Y68D,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,L112P,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,K62R,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D92N,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,L325F,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,A34P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,S362L,Likely Neutral,Likely Neutral,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Y27C,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,K342N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,S170N,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,S170R,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D162G,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,A126G,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,M134T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,T131I,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,A126D,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,G20E,Likely Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,A39P,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,Y16D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,W111R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,D24N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,R130Q,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes PTEN,I101T,Oncogenic,Loss-of-function,4,ENST00000371953,NM_000314.4,No,Yes CYLD,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000398568,NM_001042355.1,No,Yes SETD2,R1625C,Oncogenic,Loss-of-function,4,ENST00000409792,NM_014159.6,No,Yes SETD2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000409792,NM_014159.6,No,Yes SMARCA2,R1159Q,Oncogenic,Likely Loss-of-function,4,ENST00000349721,NM_001289396.1,No,Yes SMARCA2,K755R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000349721,NM_001289396.1,No,Yes MGA,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219905,NM_001164273.1,No,Yes DIS3,R780K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000377767,NM_014953.3,No,Yes DIS3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000377767,NM_014953.3,No,Yes INHA,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000243786,NM_002191.3,No,Yes MAP2K2,L46_E55del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,Q60P,Oncogenic,Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,G132D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,M150L,Likely Neutral,Likely Neutral,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,V35M,Oncogenic,Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,P268R,Likely Neutral,Likely Neutral,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,N126D,Oncogenic,Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,D71N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,Y134H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,I107N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,K61T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,E207K,Oncogenic,Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,S222D,Inconclusive,Inconclusive,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,R231H,Likely Neutral,Likely Neutral,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,S226D,Inconclusive,Inconclusive,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,F57L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,F57V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,Y134C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,L46F,Oncogenic,Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,F57C,Likely Oncogenic,Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,C125S,Oncogenic,Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,H123Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,L181M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,S154F,Likely Neutral,Neutral,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,V64D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,A110V,Likely Neutral,Likely Neutral,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,K101M,Inconclusive,Inconclusive,4,ENST00000262948,NM_030662.3,Yes,No MAP2K2,P128L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262948,NM_030662.3,Yes,No RECQL,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000421138,NM_002907.3,No,Yes TCF7L2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000543371,NM_001146274.1,No,Yes APLNR,C181S,Inconclusive,Inconclusive,4,ENST00000257254,NM_005161.4,Yes,Yes APLNR,G349E,Inconclusive,Inconclusive,4,ENST00000257254,NM_005161.4,Yes,Yes APLNR,T44S,Inconclusive,Inconclusive,4,ENST00000257254,NM_005161.4,Yes,Yes APLNR,P292L,Inconclusive,Inconclusive,4,ENST00000257254,NM_005161.4,Yes,Yes SETD3,M1_E242del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000331768,NM_032233.2,No,No DCUN1D1,L30A,Oncogenic,Likely Gain-of-function,4,ENST00000292782,NM_020640.2,Yes,No ERBB2,R138Q,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G292R,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,E1079K,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,F671N,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,S1002R,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L49H,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,K753A,Likely Neutral,Loss-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,D769Y,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G778_P780dup,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V1128I,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R683Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,I767M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,D769N,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,I263T,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,K676T,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,E812K,Resistance,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,S653C,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,P1199T,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L651V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G776S,Likely Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V777M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,A648L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,D277G,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,D962N,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,P650S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,D769A,Likely Neutral,Likely Loss-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,I682G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G309A,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,Exon 20 deletions,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,E265K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L869R,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,D277Y,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,S649T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,K753E,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,M774_A775insAYVM,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L755S,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,A710V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L755M,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G660R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,P780L,Resistance,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V659D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,D1058A,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,P489L,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,F1030C,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R1006C,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,A1232fs,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R678W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V659K,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R896G,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R678Q,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V794M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,S335C,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G776_V777insVGC,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,I655V,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V777A,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,D277H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R1153L,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,D821N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G660D,Likely Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G776V,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,D845A,Likely Neutral,Loss-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,D808N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,T686A,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G776_V777insYVMA,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L841V,Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G776delinsLC,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,E717K,Resistance,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,C334S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,A644V,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L663H,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,P1170A,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R896C,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,E719G,Resistance,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V773M,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G309E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,S310Y,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R677L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R143G,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V664F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V842I,Likely Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,D326G,Likely Neutral,Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L663P,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V480A,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V659E,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V777L,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,K753M,Likely Neutral,Loss-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,E770_A771insAYVM,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,I675M,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R677Q,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L674V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L755P,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V659G,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G776delinsVC,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,E693K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,Exon 20 insertions,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,S656C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R217C,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L915M,Resistance,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,T216S,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R784C,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,E401G,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R143Q,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,T798M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,P780_Y781insGSP,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,E321G,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,E719K,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,S633F,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L755W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,N319D,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R647T,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L866M,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,T733I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,E914K,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V773A,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,S779_P780insVGS,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,Y343C,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V665D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,Y803N,Resistance,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,A241V,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L726F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R34Q,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,A775_G776insYVMA,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R138W,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V308M,Likely Neutral,Likely Loss-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,Q680F,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,I628M,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,E930D,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,Q709L,Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,D742H,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,T862A,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L15F,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,C630Y,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,E645K,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,E645F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L755_E757delinsS,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L785F,Resistance,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,A1039T,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,S760A,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,T306M,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,S783P,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R677T,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,Y772_A775dup,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,S310F,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,N857S,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,H878Y,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,A440T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L755_T759del,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L674H,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,Y1248F,Likely Neutral,Loss-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,A644F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V750E,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,A775G,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L726I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,P1074L,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,V839G,Resistance,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R487W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G778_S779insG,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G727A,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L313V,Likely Neutral,Likely Loss-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,I654V,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,R897Q,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G135E,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G641S,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,C311R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,L651W,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,P36S,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,S792F,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,D769H,Oncogenic,Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,G222C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,A293T,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,T798I,Inconclusive,Inconclusive,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,Y835F,Likely Neutral,Likely Loss-of-function,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,S305F,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No ERBB2,Q711H,Likely Neutral,Likely Neutral,4,ENST00000269571,NM_004448.2,Yes,No RECQL4,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000428558,NM_004260.3,No,Yes ROS1,L1951R,Resistance,Inconclusive,4,ENST00000368508,NM_002944.2,Yes,No ROS1,C2060G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368508,NM_002944.2,Yes,No ROS1,G2032R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368508,NM_002944.2,Yes,No ROS1,S1986Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368508,NM_002944.2,Yes,No ROS1,D2033N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368508,NM_002944.2,Yes,No ROS1,F2004V,Inconclusive,Inconclusive,4,ENST00000368508,NM_002944.2,Yes,No ROS1,F2004C,Inconclusive,Inconclusive,4,ENST00000368508,NM_002944.2,Yes,No ROS1,V2098I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368508,NM_002944.2,Yes,No ROS1,L1947R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368508,NM_002944.2,Yes,No ROS1,S1986F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368508,NM_002944.2,Yes,No ROS1,G2101A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368508,NM_002944.2,Yes,No ROS1,E1935G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368508,NM_002944.2,Yes,No ROS1,G1971E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000368508,NM_002944.2,Yes,No NBN,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000265433,NM_002485.4,No,Yes STK11,P221R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,R104G,Likely Neutral,Likely Neutral,4,ENST00000326873,NM_000455.4,No,Yes STK11,R304W,Oncogenic,Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,K84del,Likely Neutral,Likely Neutral,4,ENST00000326873,NM_000455.4,No,Yes STK11,R211Q,Likely Neutral,Likely Neutral,4,ENST00000326873,NM_000455.4,No,Yes STK11,Y60*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,Q112E,Likely Neutral,Likely Neutral,4,ENST00000326873,NM_000455.4,No,Yes STK11,R409W,Likely Neutral,Likely Neutral,4,ENST00000326873,NM_000455.4,No,Yes STK11,G163R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,R297M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,K78I,Likely Oncogenic,Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,S31F,Likely Neutral,Likely Neutral,4,ENST00000326873,NM_000455.4,No,Yes STK11,S193Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,M136R,Likely Oncogenic,Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,H202R,Inconclusive,Inconclusive,4,ENST00000326873,NM_000455.4,No,Yes STK11,G242V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,S216F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,P275L,Likely Neutral,Likely Neutral,4,ENST00000326873,NM_000455.4,No,Yes STK11,R297S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,W308C,Likely Oncogenic,Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,K311N,Likely Neutral,Likely Neutral,4,ENST00000326873,NM_000455.4,No,Yes STK11,A205T,Oncogenic,Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,G155R,Likely Neutral,Likely Neutral,4,ENST00000326873,NM_000455.4,No,Yes STK11,G56W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,G163D,Likely Oncogenic,Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,P179R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,F148S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,D194Y,Likely Oncogenic,Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,A241P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,K78A,Likely Oncogenic,Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,W239C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,I177N,Oncogenic,Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,F354L,Likely Neutral,Likely Neutral,4,ENST00000326873,NM_000455.4,No,Yes STK11,P280A,Likely Neutral,Likely Neutral,4,ENST00000326873,NM_000455.4,No,Yes STK11,L67P,Likely Oncogenic,Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,G251C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,A397S,Likely Neutral,Likely Neutral,4,ENST00000326873,NM_000455.4,No,Yes STK11,H174R,Likely Oncogenic,Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,D176N,Likely Oncogenic,Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,G156_S169del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,E223V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,W308R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000326873,NM_000455.4,No,Yes STK11,A417S,Likely Neutral,Likely Neutral,4,ENST00000326873,NM_000455.4,No,Yes ETNK1,G245A,Inconclusive,Inconclusive,4,ENST00000266517,NM_018638.4,No,No ETNK1,N244S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000266517,NM_018638.4,No,No ETNK1,H243Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000266517,NM_018638.4,No,No AURKA,F31I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000312783,NM_003600.2,Yes,No NTRK1,G667A,Inconclusive,Inconclusive,4,ENST00000524377,NM_002529.3,Yes,No NTRK1,G595R,Likely Oncogenic,Gain-of-function,4,ENST00000524377,NM_002529.3,Yes,No NTRK1,F589L,Inconclusive,Inconclusive,4,ENST00000524377,NM_002529.3,Yes,No NTRK1,V710A,Likely Neutral,Likely Loss-of-function,4,ENST00000524377,NM_002529.3,Yes,No NTRK1,G667C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000524377,NM_002529.3,Yes,No NTRK1,Delta-NTRK1,Likely Oncogenic,Likely Gain-of-function,4,ENST00000524377,NM_002529.3,Yes,No NTRK1,TRKAIII Splice Variant,Likely Oncogenic,Likely Gain-of-function,4,ENST00000524377,NM_002529.3,Yes,No NTRK1,G667S,Inconclusive,Inconclusive,4,ENST00000524377,NM_002529.3,Yes,No NTRK1,A608D,Inconclusive,Inconclusive,4,ENST00000524377,NM_002529.3,Yes,No PIGA,R412*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000333590,NM_002641.3,No,Yes ACKR3,K206D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000272928,NM_020311,Yes,Yes ACKR3,R142A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000272928,NM_020311,Yes,Yes ACKR3,Y143A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000272928,NM_020311,Yes,Yes ACKR3,D141N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000272928,NM_020311,Yes,Yes ACKR3,D275N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000272928,NM_020311,Yes,Yes ACKR3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000272928,NM_020311,Yes,Yes ACKR3,N127S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000272928,NM_020311,Yes,Yes ACKR3,D7N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000272928,NM_020311,Yes,Yes ACKR3,D179N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000272928,NM_020311,Yes,Yes ACKR3,N127K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000272928,NM_020311,Yes,Yes ACKR3,N127D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000272928,NM_020311,Yes,Yes ACKR3,Y315A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000272928,NM_020311,Yes,Yes MDM4,G57A,Oncogenic,Loss-of-function,4,ENST00000367182,NM_002393.4,Yes,No ALDH2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000261733,NM_000690,No,Yes ALDH2,E487K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000261733,NM_000690,No,Yes TET2,S1898F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380013,NM_001127208.2,No,Yes TET2,N1387A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380013,NM_001127208.2,No,Yes TET2,Y1294A,Inconclusive,Inconclusive,4,ENST00000380013,NM_001127208.2,No,Yes TET2,R1214W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380013,NM_001127208.2,No,Yes TET2,H1382Y,Inconclusive,Inconclusive,4,ENST00000380013,NM_001127208.2,No,Yes TET2,Y1295A,Likely Neutral,Likely Neutral,4,ENST00000380013,NM_001127208.2,No,Yes TET2,R1262A,Likely Neutral,Likely Neutral,4,ENST00000380013,NM_001127208.2,No,Yes TET2,S1303N,Inconclusive,Inconclusive,4,ENST00000380013,NM_001127208.2,No,Yes TET2,R1896S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380013,NM_001127208.2,No,Yes TET2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380013,NM_001127208.2,No,Yes TET2,H1904R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380013,NM_001127208.2,No,Yes TET2,W1291R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380013,NM_001127208.2,No,Yes TET2,Y1902A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380013,NM_001127208.2,No,Yes TET2,D1384V,Inconclusive,Inconclusive,4,ENST00000380013,NM_001127208.2,No,Yes TET2,S1290A,Likely Neutral,Likely Neutral,4,ENST00000380013,NM_001127208.2,No,Yes TET2,M1293A,Inconclusive,Inconclusive,4,ENST00000380013,NM_001127208.2,No,Yes TET2,R1261G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380013,NM_001127208.2,No,Yes TET2,C1193W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380013,NM_001127208.2,No,Yes TET2,I1873T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380013,NM_001127208.2,No,Yes TET2,K1299E,Inconclusive,Inconclusive,4,ENST00000380013,NM_001127208.2,No,Yes TET2,H1881Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380013,NM_001127208.2,No,Yes TET2,R1896M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380013,NM_001127208.2,No,Yes IDH1,R132G,Oncogenic,Switch-of-function,4,ENST00000345146,NM_005896.2,Yes,No IDH1,V294M,Likely Neutral,Likely Neutral,4,ENST00000345146,NM_005896.2,Yes,No IDH1,P33S,Likely Neutral,Likely Neutral,4,ENST00000345146,NM_005896.2,Yes,No IDH1,R100A,Likely Oncogenic,Switch-of-function,4,ENST00000345146,NM_005896.2,Yes,No IDH1,Y139D,Likely Oncogenic,Switch-of-function,4,ENST00000345146,NM_005896.2,Yes,No IDH1,R49C,Likely Neutral,Loss-of-function,4,ENST00000345146,NM_005896.2,Yes,No IDH1,E190K,Likely Neutral,Likely Neutral,4,ENST00000345146,NM_005896.2,Yes,No IDH1,S280F,Inconclusive,Inconclusive,4,ENST00000345146,NM_005896.2,Yes,No IDH1,G97D,Likely Oncogenic,Switch-of-function,4,ENST00000345146,NM_005896.2,Yes,No IDH1,R132H,Oncogenic,Switch-of-function,4,ENST00000345146,NM_005896.2,Yes,No IDH1,R132L,Likely Oncogenic,Likely Switch-of-function,4,ENST00000345146,NM_005896.2,Yes,No IDH1,R132Q,Likely Oncogenic,Likely Switch-of-function,4,ENST00000345146,NM_005896.2,Yes,No IDH1,A134D,Likely Neutral,Loss-of-function,4,ENST00000345146,NM_005896.2,Yes,No IDH1,I99M,Likely Neutral,Likely Neutral,4,ENST00000345146,NM_005896.2,Yes,No IDH1,G70D,Likely Neutral,Loss-of-function,4,ENST00000345146,NM_005896.2,Yes,No IDH1,R132S,Likely Oncogenic,Switch-of-function,4,ENST00000345146,NM_005896.2,Yes,No IDH1,R132C,Oncogenic,Switch-of-function,4,ENST00000345146,NM_005896.2,Yes,No IDH1,G123R,Likely Neutral,Loss-of-function,4,ENST00000345146,NM_005896.2,Yes,No IDH1,I130M,Likely Neutral,Likely Neutral,4,ENST00000345146,NM_005896.2,Yes,No IDH1,H133Q,Likely Neutral,Likely Neutral,4,ENST00000345146,NM_005896.2,Yes,No ELF3,S308A,Likely Neutral,Likely Neutral,4,ENST00000359651,NM_004433.4,Yes,Yes ELF3,S330A,Likely Neutral,Likely Neutral,4,ENST00000359651,NM_004433.4,Yes,Yes ELF3,K320E,Likely Neutral,Likely Neutral,4,ENST00000359651,NM_004433.4,Yes,Yes ELF3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000359651,NM_004433.4,Yes,Yes ELF3,R331P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000359651,NM_004433.4,Yes,Yes ELF3,I279P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000359651,NM_004433.4,Yes,Yes ELF3,A312P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000359651,NM_004433.4,Yes,Yes RARA,R276W,Inconclusive,Inconclusive,4,ENST00000254066,NM_000964.3,No,No GATA3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000346208,NM_002051.2,Yes,Yes ID3,L64F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000374561,NM_002167.4,No,Yes ID3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000374561,NM_002167.4,No,Yes ID3,P56S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000374561,NM_002167.4,No,Yes TP53,R337P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G245A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H179Q,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y163C,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G245V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,K132N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,M246R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V173E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G154D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Q144H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L194H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L111R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G105C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E271Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P191del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,K120M,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,T125M,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,R273L,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C238G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C275W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F113S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C176W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S215R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L145R,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,N268_R273del,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,DNA binding domain insertions,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,K292T,Likely Neutral,Likely Gain-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,K292I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,K132T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,DNA binding domain missense mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H168Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V197M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G244C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P190T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,D281P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C277R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R280A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R273C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R158L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y220D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R337G,Likely Neutral,Likely Neutral,4,ENST00000269305,NM_000546.5,No,Yes TP53,Q144L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R273S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R290H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L344R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P278A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,N239K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V274A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H179D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V272M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S127P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H178N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,K291E,Likely Neutral,Likely Gain-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C141W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G154V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F113V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C277G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V216L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y126H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,T150I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,M246V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L265M,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,M237V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C176Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L257P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F134I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I195M,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,R202S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C275F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y205F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,A159D,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,G245S,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y236C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E258G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F134C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P278R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P151S,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V157D,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R248P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P151R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R282G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E271V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C135W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,A159V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P152Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F134L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P151F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V274F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G105S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H179P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P152R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C277W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V272A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I195K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L348F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I254M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,D259H,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,P190S,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,R267Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E285K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R196L,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,L265P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S215I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I255T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G356A,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,V173L,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I195S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H193P,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I254N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R158P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R342P,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P250R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,N239T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,D281G,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,R249W,Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P152K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I162M,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,S241P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R181L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R158F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F270V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,M237I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y205S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y205D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,M133K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G262V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V218E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,K120A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G245N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,M246T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y107D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E258D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L257V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I254T,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C242R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E285V,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R248G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C176G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C141S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y234N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C242W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I251M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,A161D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y236S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G244D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S127F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S240R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H214P,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,P278H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,T125K,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,E258K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R267P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F270L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P278S,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H168R,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E221Q,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,D281V,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,V216G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L330R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,M246K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L348S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S215T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,D281N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E326L,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V272K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,M133I,Likely Neutral,Likely Neutral,4,ENST00000269305,NM_000546.5,No,Yes TP53,G266R,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C238Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R110C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H168L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y205C,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,M133T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,N239H,Likely Neutral,Likely Neutral,4,ENST00000269305,NM_000546.5,No,Yes TP53,D186A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F109I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y126N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y236H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G105V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R158H,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Q136L,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,Q144P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G266E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S241F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P322R,Likely Neutral,Likely Neutral,4,ENST00000269305,NM_000546.5,No,Yes TP53,F134Y,Likely Neutral,Likely Neutral,4,ENST00000269305,NM_000546.5,No,Yes TP53,R175L,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E286V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L194F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C135Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R337H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R273G,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,D281H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Q331R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V218L,Likely Neutral,Likely Neutral,4,ENST00000269305,NM_000546.5,No,Yes TP53,C242S,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G244A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,K132Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R156H,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y205H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V157F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G154C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F338I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G244S,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y220S,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H179L,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V172G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V274L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V157G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L130P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V172D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S241Y,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,N235D,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G245R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E271K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F270S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R181C,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V274D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,M246L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V197L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C277Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,T125R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S241C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C238S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S215N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H193N,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,M237K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,K291Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H193D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S127C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R110H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,K132E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V197E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y220C,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,K132R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E286A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L330H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L330P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P153H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I254F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R248K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R273H,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R282W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I232T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H115N,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,V218G,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,C176S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,A161T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V157L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R249K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I251S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I255S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V157A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R267G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I255N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H214R,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,R158G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L257R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P219S,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,D281Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C275R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C141Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I195N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,D208N,Likely Neutral,Likely Neutral,4,ENST00000269305,NM_000546.5,No,Yes TP53,G266K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C277F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G105D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L257Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H178Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y234H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,K164E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R156C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R181P,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E180K,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L194R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R196G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Q331H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R267L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V172F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V143A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H193Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C238R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E258V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P190R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R282L,Likely Neutral,Likely Neutral,4,ENST00000269305,NM_000546.5,No,Yes TP53,V216M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,N239D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R267W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y236D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E286K,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,D281E,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,N239S,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E285Q,Likely Neutral,Likely Neutral,4,ENST00000269305,NM_000546.5,No,Yes TP53,I195T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F134V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,D208G,Likely Neutral,Likely Neutral,4,ENST00000269305,NM_000546.5,No,Yes TP53,R280I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R290G,Likely Neutral,Likely Gain-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R248W,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C135G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R249M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C275G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V272L,Likely Oncogenic,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,S121Y,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y205N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y126D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R283Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R280K,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H233N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P151T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R110P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C135F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E258Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C135S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G199R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H178P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R213Q,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V143E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C141G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E258A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y126C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F341C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R249S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,D208E,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,R248Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y236N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F270I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S127T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,T123A,Likely Neutral,Likely Neutral,4,ENST00000269305,NM_000546.5,No,Yes TP53,K120E,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H193R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F212Y,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,F109V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S215C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R282P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G105R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C242Y,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I254L,Likely Neutral,Likely Neutral,4,ENST00000269305,NM_000546.5,No,Yes TP53,R181H,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V143M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S121F,Likely Neutral,Likely Gain-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L111M,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y163N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I195F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S215G,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R280T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C238F,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L130F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I232N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S241A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L265R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,K132M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,D208V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G266V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V218dup,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C124R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P151L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R249I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C176R,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R282Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,A161V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R175G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V216E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G244R,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R248L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V173M,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P190L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I251F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H179R,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H168P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S127Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S121C,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,Q136P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H179N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G245C,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y163D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H214Q,Likely Neutral,Likely Neutral,4,ENST00000269305,NM_000546.5,No,Yes TP53,L344P,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G334R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R110L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P152T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V272E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H179Y,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,T329I,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,H214N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I251N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,T155N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R249T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y220N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R175H,Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V143G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R273K,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,A161S,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H168N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P152S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P278L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F109S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R158S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C229R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C242G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V218M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Q136E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C141R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,K120N,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y234D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C275S,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C242F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V173A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L130V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,K120R,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,D281A,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y234S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F113P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,D259V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R175C,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,A159P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S241T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y220H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C277Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C141F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I254V,Likely Neutral,Likely Neutral,4,ENST00000269305,NM_000546.5,No,Yes TP53,L111P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P151A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E286Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R337C,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Tetramerization domain insertions,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G244F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y163H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P151H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,DNA binding domain deletions,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I255F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L130H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,T125P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,A347T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Tetramerization domain deletions,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C135R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R273P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V274G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R158C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P250L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,A161P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,N131K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L194P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,N247I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C275Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I232S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,N131I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P316L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R280S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V272G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F109C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C176F,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H193Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H193L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,S121A,Likely Neutral,Likely Gain-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y234C,Likely Oncogenic,Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P278T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,T125A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R337L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R337S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H178D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,C238W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,M133R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L111Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,D259Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,L130R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F270C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,I232F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H297N,Likely Neutral,Likely Neutral,4,ENST00000269305,NM_000546.5,No,Yes TP53,T155I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,E286G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F113L,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,P278F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G244V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F328V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,F113C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Y126S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,D259N,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,R249G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Q136H,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,I254S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,N131S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,P152L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,Q144R,Inconclusive,Inconclusive,4,ENST00000269305,NM_000546.5,No,Yes TP53,P47S,Likely Neutral,Neutral,4,ENST00000269305,NM_000546.5,No,Yes TP53,F134S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,M246I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,T155P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V173G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,V197G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,H214L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,R280G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes TP53,G245D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000269305,NM_000546.5,No,Yes EPAS1,P531L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263734,NM_001430.4,No,No EPAS1,I533_P534del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263734,NM_001430.4,No,No EPAS1,P531S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263734,NM_001430.4,No,No EPAS1,A530V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263734,NM_001430.4,No,No EPAS1,P531A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263734,NM_001430.4,No,No EPAS1,P534_D536del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263734,NM_001430.4,No,No EPAS1,A530T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263734,NM_001430.4,No,No EPAS1,Y532C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263734,NM_001430.4,No,No RNASEH2A,R280G,Likely Neutral,Likely Loss-of-function,4,ENST00000221486,NM_006397,Yes,No RNASEH2A,V133M,Likely Neutral,Likely Loss-of-function,4,ENST00000221486,NM_006397,Yes,No RNASEH2A,P158S,Likely Neutral,Likely Loss-of-function,4,ENST00000221486,NM_006397,Yes,No SDHC,G75D,Inconclusive,Inconclusive,4,ENST00000367975,NM_003001.3,No,Yes SDHC,R133*,Likely Oncogenic,Loss-of-function,4,ENST00000367975,NM_003001.3,No,Yes SDHC,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000367975,NM_003001.3,No,Yes SHOC2,M173I,Likely Oncogenic,Loss-of-function,4,ENST00000369452,NM_007373.3,Yes,No SHOC2,S2G,Likely Oncogenic,Loss-of-function,4,ENST00000369452,NM_007373.3,Yes,No EPHB1,G628W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000398015,NM_004441.4,No,Yes EPHB1,R351W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000398015,NM_004441.4,No,Yes EPHB1,R84H,Likely Neutral,Likely Neutral,4,ENST00000398015,NM_004441.4,No,Yes EPHB1,R90C,Likely Neutral,Likely Neutral,4,ENST00000398015,NM_004441.4,No,Yes SPRED1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000299084,NM_152594.2,No,Yes SDHB,W200C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000375499,NM_003000.2,No,Yes SDHB,C196Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000375499,NM_003000.2,No,Yes SDHB,S100F,Inconclusive,Inconclusive,4,ENST00000375499,NM_003000.2,No,Yes SDHB,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000375499,NM_003000.2,No,Yes SDHB,I127S,Likely Neutral,Likely Neutral,4,ENST00000375499,NM_003000.2,No,Yes SDHB,R242H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000375499,NM_003000.2,No,Yes SDHB,R46Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000375499,NM_003000.2,No,Yes H1-5,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000331442,NM_005322.2,No,Yes CCND3,Q276*,Likely Oncogenic,Gain-of-function,4,ENST00000372991,NM_001760.3,Yes,No CCND3,P284L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000372991,NM_001760.3,Yes,No CCND3,D286_L292trunc,Likely Oncogenic,Likely Gain-of-function,4,ENST00000372991,NM_001760.3,Yes,No CCND3,T283A,Likely Oncogenic,Gain-of-function,4,ENST00000372991,NM_001760.3,Yes,No CCND3,T285A,Likely Oncogenic,Gain-of-function,4,ENST00000372991,NM_001760.3,Yes,No CCND3,I290R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000372991,NM_001760.3,Yes,No GATA2,G320D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000341105,NM_032638.4,Yes,No GATA2,R308P,Likely Neutral,Likely Neutral,4,ENST00000341105,NM_032638.4,Yes,No GATA2,A318T,Likely Neutral,Likely Loss-of-function,4,ENST00000341105,NM_032638.4,Yes,No GATA2,L321F,Likely Neutral,Likely Loss-of-function,4,ENST00000341105,NM_032638.4,Yes,No INPP4B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262992,NM_001101669.1,No,Yes H3-3A,G35R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000366813,NM_002107.4,Yes,No H3-3A,K28M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000366813,NM_002107.4,Yes,No H3-3A,G35V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000366813,NM_002107.4,Yes,No PRKN,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000366898,NM_004562.2,No,Yes SUFU,N328K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000369902,NM_016169.3,No,Yes SUFU,G64V,Likely Neutral,Likely Neutral,4,ENST00000369902,NM_016169.3,No,Yes SUFU,R339W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000369902,NM_016169.3,No,Yes SUFU,I57N,Likely Neutral,Likely Neutral,4,ENST00000369902,NM_016169.3,No,Yes SUFU,S351G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000369902,NM_016169.3,No,Yes SUFU,G334D,Likely Neutral,Likely Neutral,4,ENST00000369902,NM_016169.3,No,Yes SUFU,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000369902,NM_016169.3,No,Yes LATS1,Truncating Mutations,Likely Oncogenic,Loss-of-function,4,ENST00000253339,NM_004690.3,No,Yes PIK3CB,D1067Y,Oncogenic,Gain-of-function,4,ENST00000289153,NM_006219.2,Yes,No PIK3CB,A593V,Likely Neutral,Likely Neutral,4,ENST00000289153,NM_006219.2,Yes,No PIK3CB,D1067V,Oncogenic,Gain-of-function,4,ENST00000289153,NM_006219.2,Yes,No PIK3CB,E470K,Oncogenic,Gain-of-function,4,ENST00000289153,NM_006219.2,Yes,No PIK3CB,A1048V,Oncogenic,Gain-of-function,4,ENST00000289153,NM_006219.2,Yes,No PIK3CB,D1067A,Likely Oncogenic,Gain-of-function,4,ENST00000289153,NM_006219.2,Yes,No PIK3CB,E552K,Likely Oncogenic,Gain-of-function,4,ENST00000289153,NM_006219.2,Yes,No PIK3CB,E633K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000289153,NM_006219.2,Yes,No PIK3CB,E1051K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000289153,NM_006219.2,Yes,No PIK3CB,E497D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000289153,NM_006219.2,Yes,No KIT,N463S,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,V560E,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,V559A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,D816A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,D816H,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,S501_A502dup,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,K509I,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,Y553_Q556del,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,Y553_K558del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,D816F,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,V560A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,N822K,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,D816N,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,D820V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,L576del,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,K558_V559del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,P577_R588dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,D816Y,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,Y418_D419del,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,W557_V559delinsC,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,W557R,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,N822I,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,N655K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,N564_Y578del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,Y578_D579insEQQLPY,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,A829P,Resistance,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,D816E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,V555_V559del,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,I653T,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,D737N,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,D572A,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,V555_L576del,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,V559I,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,T574_R588delinsL,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,M552_W557del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,W557G,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,K550_K558del,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,L576P,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,K642E,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,D52N,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,C443Y,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,N505I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,P573Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,V559_G565del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,Y570H,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,T574insTQLPYD,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,X550_splice,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,E490K,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,D820G,Resistance,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,D579del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,A502_Y503dup,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,D820A,Resistance,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,R796G,Likely Neutral,Loss-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,D820E,Resistance,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,P838L,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,R634W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,F522C,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,D816V,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,Y578_D579dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,W557C,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,S709F,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,V559G,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,V560G,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,W557_V560del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,K558_E562del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,N822Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,V530I,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,W557_K558del,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,A504_Y505ins,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,T670I,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,Q556_K558del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,Y578C,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,Y553N,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,E839K,Likely Neutral,Loss-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,M541L,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,C809G,Resistance,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,Q575_P585dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,H697Y,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,R888Q,Likely Neutral,Likely Loss-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,T417_D419delinsI,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,V560D,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,K558delinsNP,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,I563_L576del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,N822H,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,E554_V559del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,V559C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,P551_E554del,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,E554_I571del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,D60N,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,Y823D,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,P551_M552del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,V654A,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,D820Y,Resistance,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,V559D,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,D816G,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,P573_D579del,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,P577_D579del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,E554_K558del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,S476I,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,M552_K558del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,Exon 11 deletions,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,V560del,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,V852I,Inconclusive,Inconclusive,4,ENST00000288135,NM_000222.2,Yes,No KIT,P551_W557delinsL,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,T417_D419delinsRG,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,K550_W557del,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,D419del,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,Y568_L576delinsVN,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,K558_V560del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,P577_W582delinsPYD,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,V559_V560del,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,P551_V555del,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,V559del,Likely Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,K558N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,V569_L576del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,K550_V555delinsI,Oncogenic,Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No KIT,V559F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288135,NM_000222.2,Yes,No RHOA,G14V,Likely Neutral,Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,G62E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,G17A,Likely Oncogenic,Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,T37Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,Y42C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,E40N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,Y42S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,G17E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,A161V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,L69P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,A161P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,E40K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,T19N,Inconclusive,Inconclusive,4,ENST00000418115,NM_001664.2,Yes,No RHOA,C16R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,Y34C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,T37A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,E40T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,L57V,Oncogenic,Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,L69R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,E40L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,C16F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,G17V,Oncogenic,Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,E40Q,Likely Neutral,Likely Neutral,4,ENST00000418115,NM_001664.2,Yes,No RHOA,E40W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,R5W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,Y34F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,A161E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,K118E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,R5Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,Y42F,Likely Neutral,Likely Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RHOA,E47K,Likely Neutral,Likely Loss-of-function,4,ENST00000418115,NM_001664.2,Yes,No RAF1,R554K,Likely Neutral,Likely Neutral,4,ENST00000251849,NM_002880.3,Yes,No RAF1,E478K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,S257P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,P261T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,S259P,Likely Oncogenic,Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,S257L,Oncogenic,Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,S259F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,S259C,Likely Neutral,Likely Neutral,4,ENST00000251849,NM_002880.3,Yes,No RAF1,I448V,Inconclusive,Inconclusive,4,ENST00000251849,NM_002880.3,Yes,No RAF1,D447N,Likely Neutral,Likely Neutral,4,ENST00000251849,NM_002880.3,Yes,No RAF1,S257W,Likely Oncogenic,Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,R391W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,M469I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,G361A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,D486N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,P261L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,P261S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,G356E,Likely Neutral,Likely Neutral,4,ENST00000251849,NM_002880.3,Yes,No RAF1,T491I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,S259A,Oncogenic,Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,L613V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,K106N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,S427G,Oncogenic,Gain-of-function,4,ENST00000251849,NM_002880.3,Yes,No RAF1,S427T,Likely Neutral,Likely Neutral,4,ENST00000251849,NM_002880.3,Yes,No TET1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373644,NM_030625.2,No,Yes KLF5,P301S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000377687,NM_001730.4,Yes,No KLF5,E419Q,Oncogenic,Gain-of-function,4,ENST00000377687,NM_001730.4,Yes,No KLF5,E419K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000377687,NM_001730.4,Yes,No KLF5,S303P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000377687,NM_001730.4,Yes,No KLF5,P304A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000377687,NM_001730.4,Yes,No KLF5,D418N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000377687,NM_001730.4,Yes,No IDH2,R140Q,Oncogenic,Switch-of-function,4,ENST00000330062,NM_002168.2,Yes,No IDH2,R172G,Likely Oncogenic,Likely Switch-of-function,4,ENST00000330062,NM_002168.2,Yes,No IDH2,R140W,Likely Oncogenic,Likely Switch-of-function,4,ENST00000330062,NM_002168.2,Yes,No IDH2,R172T,Likely Oncogenic,Likely Switch-of-function,4,ENST00000330062,NM_002168.2,Yes,No IDH2,R172W,Likely Oncogenic,Likely Switch-of-function,4,ENST00000330062,NM_002168.2,Yes,No IDH2,I319M,Inconclusive,Inconclusive,4,ENST00000330062,NM_002168.2,Yes,No IDH2,R172K,Oncogenic,Switch-of-function,4,ENST00000330062,NM_002168.2,Yes,No IDH2,R172S,Oncogenic,Switch-of-function,4,ENST00000330062,NM_002168.2,Yes,No IDH2,R172M,Likely Oncogenic,Likely Switch-of-function,4,ENST00000330062,NM_002168.2,Yes,No IDH2,Q316E,Inconclusive,Inconclusive,4,ENST00000330062,NM_002168.2,Yes,No ERF,Truncating Mutations,Likely Oncogenic,Loss-of-function,4,ENST00000222329,NM_006494.2,No,Yes SETBP1,G870S,Oncogenic,Gain-of-function,4,ENST00000282030,NM_015559.2,Yes,No SETBP1,I871S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000282030,NM_015559.2,Yes,No SETBP1,D868N,Oncogenic,Gain-of-function,4,ENST00000282030,NM_015559.2,Yes,No SETBP1,I871T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000282030,NM_015559.2,Yes,No SETBP1,D868Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000282030,NM_015559.2,Yes,No SETBP1,I865,Inconclusive,Inconclusive,4,ENST00000282030,NM_015559.2,Yes,No SETBP1,S869R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000282030,NM_015559.2,Yes,No SETBP1,E858K,Inconclusive,Inconclusive,4,ENST00000282030,NM_015559.2,Yes,No SETBP1,T864,Inconclusive,Inconclusive,4,ENST00000282030,NM_015559.2,Yes,No CCND1,L283_D294del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000227507,NM_053056.2,Yes,No CCND1,T286I,Oncogenic,Gain-of-function,4,ENST00000227507,NM_053056.2,Yes,No CCND1,Y44D,Likely Oncogenic,Gain-of-function,4,ENST00000227507,NM_053056.2,Yes,No CCND1,C47S,Likely Oncogenic,Gain-of-function,4,ENST00000227507,NM_053056.2,Yes,No CCND1,D289_D292del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000227507,NM_053056.2,Yes,No CCND1,D289A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000227507,NM_053056.2,Yes,No CCND1,D289del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000227507,NM_053056.2,Yes,No CCND1,T286A,Oncogenic,Gain-of-function,4,ENST00000227507,NM_053056.2,Yes,No CCND1,P287A,Likely Oncogenic,Gain-of-function,4,ENST00000227507,NM_053056.2,Yes,No CCND1,256_286trunc,Likely Oncogenic,Gain-of-function,4,ENST00000227507,NM_053056.2,Yes,No CCND1,P287S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000227507,NM_053056.2,Yes,No CCND1,V293A,Inconclusive,Inconclusive,4,ENST00000227507,NM_053056.2,Yes,No CCND1,P287T,Oncogenic,Gain-of-function,4,ENST00000227507,NM_053056.2,Yes,No RNASEH2B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000336617,NM_024570,No,Yes RNASEH2B,E202*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000336617,NM_024570,No,Yes PTPN11,D61N,Oncogenic,Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,D61Y,Oncogenic,Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,K590R,Likely Neutral,Likely Loss-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,V45L,Likely Oncogenic,Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,M504V,Oncogenic,Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,S502T,Likely Oncogenic,Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,P491S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,E76A,Oncogenic,Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,T73I,Oncogenic,Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,Y63C,Likely Oncogenic,Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,G503V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,G464A,Inconclusive,Inconclusive,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,I282V,Oncogenic,Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,E139D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,A72S,Oncogenic,Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,N308D,Oncogenic,Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,R498L,Inconclusive,Inconclusive,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,F71I,Oncogenic,Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,T468M,Oncogenic,Loss-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,E76Q,Likely Neutral,Likely Neutral,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,E76K,Oncogenic,Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,Q510E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,R498W,Likely Neutral,Likely Loss-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,A72V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,F285S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,Q79R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,D106A,Oncogenic,Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,T507K,Oncogenic,Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,E69K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,Y62C,Likely Oncogenic,Gain-of-function,4,ENST00000351677,NM_002834.3,Yes,No PTPN11,A461T,Likely Oncogenic,Loss-of-function,4,ENST00000351677,NM_002834.3,Yes,No SMARCB1,R377C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263121,NM_003073.3,No,Yes SMARCB1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263121,NM_003073.3,No,Yes SMARCB1,K363N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263121,NM_003073.3,No,Yes SMARCB1,R377H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263121,NM_003073.3,No,Yes SMARCB1,K364del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263121,NM_003073.3,No,Yes SMARCB1,R366C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263121,NM_003073.3,No,Yes ESR1,Y537S,Oncogenic,Gain-of-function,4,ENST00000206249,NM_001122740.1,Yes,No ESR1,L536H,Likely Oncogenic,Gain-of-function,4,ENST00000206249,NM_001122740.1,Yes,No ESR1,S463P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000206249,NM_001122740.1,Yes,No ESR1,V534E,Likely Neutral,Likely Neutral,4,ENST00000206249,NM_001122740.1,Yes,No ESR1,Y537D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000206249,NM_001122740.1,Yes,No ESR1,L469V,Likely Oncogenic,Gain-of-function,4,ENST00000206249,NM_001122740.1,Yes,No ESR1,E380Q,Likely Oncogenic,Gain-of-function,4,ENST00000206249,NM_001122740.1,Yes,No ESR1,V422del,Likely Oncogenic,Gain-of-function,4,ENST00000206249,NM_001122740.1,Yes,No ESR1,Y537C,Likely Oncogenic,Gain-of-function,4,ENST00000206249,NM_001122740.1,Yes,No ESR1,D538G,Oncogenic,Gain-of-function,4,ENST00000206249,NM_001122740.1,Yes,No ESR1,S432L,Likely Neutral,Likely Neutral,4,ENST00000206249,NM_001122740.1,Yes,No ESR1,Y537N,Likely Oncogenic,Gain-of-function,4,ENST00000206249,NM_001122740.1,Yes,No ESR1,L536Q,Likely Oncogenic,Gain-of-function,4,ENST00000206249,NM_001122740.1,Yes,No ESR1,L540Q,Inconclusive,Inconclusive,4,ENST00000206249,NM_001122740.1,Yes,No ESR1,L536P,Likely Oncogenic,Gain-of-function,4,ENST00000206249,NM_001122740.1,Yes,No ESR1,K303R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000206249,NM_001122740.1,Yes,No ESR1,L536R,Likely Oncogenic,Gain-of-function,4,ENST00000206249,NM_001122740.1,Yes,No CREBBP,H1487Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,Y1503S,Likely Oncogenic,Loss-of-function,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,Q1500P,Likely Neutral,Likely Neutral,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,R1563S,Likely Neutral,Likely Neutral,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,Y1450C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,S1680del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,Y1482H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,D1435H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,W1502A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,D1435E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,R1446H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,Y1503D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,W1502C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,R1446C,Likely Oncogenic,Loss-of-function,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,R1446G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,K1320R,Likely Neutral,Likely Neutral,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,Y1503F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262367,NM_004380.2,No,Yes CREBBP,S1436N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262367,NM_004380.2,No,Yes ESCO2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000305188,NM_001017420.2,No,Yes STAG2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000218089,NM_001042749.1,No,Yes RAD21,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000297338,NM_006265.2,No,Yes REST,S593N,Likely Neutral,Likely Neutral,4,ENST00000309042,NM_001193508.1,No,Yes REST,H322R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000309042,NM_001193508.1,No,Yes REST,A642T,Likely Neutral,Likely Neutral,4,ENST00000309042,NM_001193508.1,No,Yes REST,R160P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000309042,NM_001193508.1,No,Yes REST,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000309042,NM_001193508.1,No,Yes REST,E91G,Likely Neutral,Likely Neutral,4,ENST00000309042,NM_001193508.1,No,Yes REST,N290Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000309042,NM_001193508.1,No,Yes REST,H918Y,Likely Neutral,Likely Neutral,4,ENST00000309042,NM_001193508.1,No,Yes REST,M420T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000309042,NM_001193508.1,No,Yes SDHA,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264932,NM_004168.2,No,Yes FAS,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000355740,NM_000043.4,No,Yes KLF4,K409Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000374672,NM_004235.4,Yes,Yes KLF4,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000374672,NM_004235.4,Yes,Yes KDR,Q472H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263923,NM_002253.2,Yes,No KDR,R1032Q,Likely Neutral,Likely Loss-of-function,4,ENST00000263923,NM_002253.2,Yes,No KDR,G800R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263923,NM_002253.2,Yes,No KDR,G843D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263923,NM_002253.2,Yes,No KDR,R1022Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263923,NM_002253.2,Yes,No KDR,S925F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263923,NM_002253.2,Yes,No KDR,D717V,Oncogenic,Gain-of-function,4,ENST00000263923,NM_002253.2,Yes,No KDR,L840F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263923,NM_002253.2,Yes,No KDR,T771R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263923,NM_002253.2,Yes,No KDR,C482R,Inconclusive,Inconclusive,4,ENST00000263923,NM_002253.2,Yes,No KDR,S1100F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263923,NM_002253.2,Yes,No KDR,A1065T,Likely Oncogenic,Gain-of-function,4,ENST00000263923,NM_002253.2,Yes,No KDR,G800D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263923,NM_002253.2,Yes,No GAB1,T387N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262994,NM_002039.3,Yes,No GAB1,Y83C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262994,NM_002039.3,Yes,No LATS2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000382592,NM_014572.2,No,Yes PIK3CA,E109_I112delinsD,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,V105_R108delVGNR,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R38C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,Y1021C,Inconclusive,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R818C,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E39K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,G451R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,P449T,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,F614I,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R115P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,M1043V,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,V344M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,I910V,Inconclusive,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R382K,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,G363A,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,N345I,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,C378Y,Inconclusive,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E600K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E365K,Likely Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E542V,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E545D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,P471L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,I391M,Inconclusive,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,C604R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E149G,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,P449_L455delPHGLEDL,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R108H,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,C901F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,H1047L,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R115L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E218K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,C378R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,M1043L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,D939G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,N345T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,N1068Kfs*5,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,M1004I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,T1025A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,M1V,Inconclusive,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,V356I,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,L766F,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,G364R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E726K,Inconclusive,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R975S,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,W11L,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,P124L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E579K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E453K,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R108S,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E542A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,N345K,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E110K,Inconclusive,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,K111del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,Q546E,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,G118D,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E970K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,K111N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,H450_P458del,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,M1040V,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E545K,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E453Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E81K,Inconclusive,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,G106D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E78K,Resistance,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,G106_R108del,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,S629C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,G1049R,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,H1047R,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,V344G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,V638A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,D350G,Likely Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E545G,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E365V,Inconclusive,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R93P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E542Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,P487Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,G914R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,T1025S,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,L456Afs*13,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E1037K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,C24Y,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E116K,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,P366R,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,N1068fs*4,Inconclusive,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,D549N,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R93W,Likely Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E453A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,Q60K,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,N1044K,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,Y1021H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R108C,Inconclusive,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,A1066V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,C971R,Inconclusive,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E103_G106delinsD,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R108L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E542K,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,G106V,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E545Q,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,M1043I,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,Q546R,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R398H,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,Q546K,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E545A,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,D1029Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,T1025N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E103_P104delEP,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,Q546L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,H701P,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,C420R,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,K111E,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,C420G,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,G106R,Likely Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,P449_L455del,Likely Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E110del,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R38H,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R93Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,V344A,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,G451V,Inconclusive,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,H1047Y,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,P539R,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E542G,Inconclusive,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,Q546P,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,E547K,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,P447_L455del,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,A1020V,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R88Q,Oncogenic,Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,G1007R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,I112N,Inconclusive,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,S332_L334delSAL,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,P104L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,I31M,Likely Neutral,Likely Neutral,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,D350N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000263967,NM_006218.2,Yes,No PIK3CA,R38S,Inconclusive,Inconclusive,4,ENST00000263967,NM_006218.2,Yes,No ATXN7,P42_P43insP,Likely Oncogenic,Likely Gain-of-function,4,ENST00000295900,NM_000333.3,Yes,No ATXN7,Q39P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000295900,NM_000333.3,Yes,No ATXN7,P40Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000295900,NM_000333.3,Yes,No ATXN7,Q30R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000295900,NM_000333.3,Yes,No FUBP1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000370768,NM_003902.3,No,Yes ECT2L,Truncating Mutations,Inconclusive,Inconclusive,4,ENST00000367682,NM_001077706.2,No,Yes MEF2B,D83V,Oncogenic,Gain-of-function,4,ENST00000162023,NM_001145785.1,Yes,No MEF2B,K4E,Oncogenic,Loss-of-function,4,ENST00000162023,NM_001145785.1,Yes,No MEF2B,N81Y,Inconclusive,Inconclusive,4,ENST00000162023,NM_001145785.1,Yes,No MEF2B,E77K,Oncogenic,Likely Gain-of-function,4,ENST00000162023,NM_001145785.1,Yes,No MEF2B,Y69H,Oncogenic,Likely Gain-of-function,4,ENST00000162023,NM_001145785.1,Yes,No RET,D631Y,Likely Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,D631N,Likely Neutral,Likely Neutral,4,ENST00000355710,NM_020975.4,Yes,No RET,Y791F,Likely Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,D631G,Likely Neutral,Likely Neutral,4,ENST00000355710,NM_020975.4,Yes,No RET,I852M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,D631A,Likely Neutral,Likely Neutral,4,ENST00000355710,NM_020975.4,Yes,No RET,A919P,Inconclusive,Inconclusive,4,ENST00000355710,NM_020975.4,Yes,No RET,G810S,Resistance,Inconclusive,4,ENST00000355710,NM_020975.4,Yes,No RET,C611Y,Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,S904F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,C634W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,T338I,Inconclusive,Inconclusive,4,ENST00000355710,NM_020975.4,Yes,No RET,R886W,Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,C618R,Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,S649L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,S765P,Likely Neutral,Loss-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,C630R,Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,M918T,Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,S891A,Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,V804L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,Y806C,Inconclusive,Inconclusive,4,ENST00000355710,NM_020975.4,Yes,No RET,C620R,Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,E921K,Likely Neutral,Loss-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,E768D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,G810C,Resistance,Inconclusive,4,ENST00000355710,NM_020975.4,Yes,No RET,E632_L633del,Likely Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,R873Q,Likely Neutral,Loss-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,R897Q,Likely Neutral,Loss-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,V804M,Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,E511K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,D898_E901del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,A883T,Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,A883F,Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,M980T,Likely Neutral,Likely Neutral,4,ENST00000355710,NM_020975.4,Yes,No RET,R833C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,K603Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,E505_G506del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,M918V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,C634Y,Likely Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,L633_C634dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,V648I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,V804G,Likely Neutral,Likely Loss-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,D631_L633delinsE,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,C609Y,Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,M848T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,F893L,Likely Neutral,Loss-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,C634S,Likely Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,C634R,Oncogenic,Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No RET,A919V,Inconclusive,Inconclusive,4,ENST00000355710,NM_020975.4,Yes,No RET,G885R,Inconclusive,Inconclusive,4,ENST00000355710,NM_020975.4,Yes,No RET,L790F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000355710,NM_020975.4,Yes,No ASXL2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000435504,NM_018263.4,No,Yes JAK2,R683K,Oncogenic,Gain-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,Y931C,Oncogenic,Likely Gain-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,Y1045*,Resistance,Inconclusive,4,ENST00000381652,NM_004972.3,Yes,No JAK2,I1018W,Resistance,Inconclusive,4,ENST00000381652,NM_004972.3,Yes,No JAK2,T875N,Oncogenic,Gain-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,R683G,Oncogenic,Gain-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,Y1045W,Resistance,Inconclusive,4,ENST00000381652,NM_004972.3,Yes,No JAK2,G417P,Resistance,Inconclusive,4,ENST00000381652,NM_004972.3,Yes,No JAK2,G571S,Likely Neutral,Likely Neutral,4,ENST00000381652,NM_004972.3,Yes,No JAK2,R1113H,Likely Neutral,Loss-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,V617F,Oncogenic,Gain-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,D544H,Resistance,Inconclusive,4,ENST00000381652,NM_004972.3,Yes,No JAK2,E1024R,Likely Neutral,Loss-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,S1025C,Resistance,Inconclusive,4,ENST00000381652,NM_004972.3,Yes,No JAK2,Exon 12 missense mutations,Likely Oncogenic,Gain-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,H538Q,Oncogenic,Gain-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,S1039F,Resistance,Inconclusive,4,ENST00000381652,NM_004972.3,Yes,No JAK2,G335D,Likely Neutral,Likely Neutral,4,ENST00000381652,NM_004972.3,Yes,No JAK2,I1018F,Resistance,Inconclusive,4,ENST00000381652,NM_004972.3,Yes,No JAK2,L983F,Resistance,Inconclusive,4,ENST00000381652,NM_004972.3,Yes,No JAK2,L611V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,Exon 12 deletions,Likely Oncogenic,Gain-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,R683T,Oncogenic,Likely Gain-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,R683S,Oncogenic,Gain-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,C618R,Oncogenic,Gain-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,Exon 12 insertions,Likely Oncogenic,Gain-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,F537_K539delinsL,Oncogenic,Gain-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,L1026F,Resistance,Inconclusive,4,ENST00000381652,NM_004972.3,Yes,No JAK2,F1061W,Resistance,Inconclusive,4,ENST00000381652,NM_004972.3,Yes,No JAK2,N542_E543del,Oncogenic,Gain-of-function,4,ENST00000381652,NM_004972.3,Yes,No JAK2,W1038C,Resistance,Inconclusive,4,ENST00000381652,NM_004972.3,Yes,No JAK2,L551P,Oncogenic,Inconclusive,4,ENST00000381652,NM_004972.3,Yes,No JAK2,V1075F,Resistance,Inconclusive,4,ENST00000381652,NM_004972.3,Yes,No JAK2,R426K,Resistance,Inconclusive,4,ENST00000381652,NM_004972.3,Yes,No JAK2,K539L,Oncogenic,Gain-of-function,4,ENST00000381652,NM_004972.3,Yes,No PRPF8,M1307I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304992,NM_006445,No,Yes PRPF8,H1875R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304992,NM_006445,No,Yes PRPF8,A687P,Likely Neutral,Likely Neutral,4,ENST00000304992,NM_006445,No,Yes PRPF8,G1750E,Likely Neutral,Likely Neutral,4,ENST00000304992,NM_006445,No,Yes PRPF8,E1292K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304992,NM_006445,No,Yes PRPF8,D1598Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304992,NM_006445,No,Yes PRPF8,V1015N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304992,NM_006445,No,Yes PRPF8,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000304992,NM_006445,No,Yes XPO1,C528S,Inconclusive,Inconclusive,4,ENST00000401558,NM_003400.3,Yes,No XPO1,R749Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000401558,NM_003400.3,Yes,No XPO1,E571K,Oncogenic,Gain-of-function,4,ENST00000401558,NM_003400.3,Yes,No HLA-C,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000376228,NM_002117.5,No,Yes EZHIP,Y184C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000342995,NM_203407.2,Yes,No EZHIP,T73S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000342995,NM_203407.2,Yes,No EZHIP,I88F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000342995,NM_203407.2,Yes,No MAPK1,R67I,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,C127I,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I56K,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I347Y,Inconclusive,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y36T,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I56G,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,P58Q,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,L75H,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,G37K,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I56Q,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,L75E,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I31C,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y36E,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Q105W,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,F59S,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,T110P,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,S142L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y64A,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,F59G,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I347F,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,P58L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,T68M,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,G37A,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y36S,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,D100M,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,E71G,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y64Q,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,E71P,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I56E,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I31M,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,P58M,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,S57F,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I103Q,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,T68P,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,E322V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y43W,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y36Q,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,D321N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,M38P,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,F59R,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,F59P,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,G37D,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y36A,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,P58K,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I56H,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,L156G,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,D321V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,P58A,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I56Y,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y36C,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I31W,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,E33P,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y64I,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,V49A,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y64P,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,M98W,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I56P,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I31H,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I347W,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,P58V,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,E60S,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,L156N,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,E322K,Likely Oncogenic,Gain-of-function,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,V39A,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Q105I,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,G37S,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y64G,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,P58T,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,P58Y,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,P58G,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y36D,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,L75R,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,G37P,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I31Y,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,V51H,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Q105V,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,E81K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y36R,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I31K,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,L75W,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I31L,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I56W,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I56D,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I31R,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,C65Y,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,A35N,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y64T,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y64R,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,E71C,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y36N,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,S57G,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,K55G,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,R15P,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I31Q,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I31E,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,E71K,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Q105T,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,G37T,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,R191H,Likely Neutral,Likely Loss-of-function,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,P58N,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,E322A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y43E,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y64M,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Q62P,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Q105Y,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Q105F,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I347H,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,T68Y,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y64C,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,V51K,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,T68D,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y64K,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,E71A,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y187A,Likely Neutral,Likely Loss-of-function,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y64D,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y64L,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,C40R,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I31N,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,P58S,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y233A,Likely Neutral,Likely Loss-of-function,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,G37C,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,T68H,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I56S,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,T68Q,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,P58W,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y36G,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I103W,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Q97R,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I31D,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,L69R,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,T68N,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,S57P,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,T68I,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,G32P,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y64E,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,T185A,Likely Neutral,Likely Loss-of-function,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,T68L,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y64V,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,P58F,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I103Y,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,L75P,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,C40P,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,D124T,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y36H,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,G169D,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y36V,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,G37N,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,T68F,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,C65W,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,E60Q,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y36I,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,C65F,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y64S,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,P58R,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y36M,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Q105N,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,D44H,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,Y36L,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,I347M,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No MAPK1,P58I,Resistance,Inconclusive,4,ENST00000215832,NM_002745.4,Yes,No PTPN2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000309660,NM_002828.3,No,Yes H1-2,S102F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000343677,NM_005319.3,No,No CDKN1A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000244741,NM_078467.2,No,Yes CDKN1A,S31R,Inconclusive,Inconclusive,4,ENST00000244741,NM_078467.2,No,Yes MET,H1106D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,F1200I,Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,D1002A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,D1010,Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,N375S,Inconclusive,Inconclusive,4,ENST00000397752,NM_000245.2,Yes,No MET,X1008_splice,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,V1220I,Likely Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,Y1003F,Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,Y1003,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,M1250T,Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,981_1028splice,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,H1094R,Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,Y1230H,Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,Exon 14 Skipping Mutation,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,Exon 14 skipping mutation,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,Exon 14 deletions,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,D1228N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,X1010_splice,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,D1010H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,X1009_splice,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,Y1235D,Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,Exon 14 splice mutations,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,X1007_splice,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,L1195V,Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,D1010Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,V1070E,Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,D1010N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,N1100Y,Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,H1094Y,Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,X963_splice,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,Y1230C,Likely Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,V1092I,Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,D1228H,Resistance,Inconclusive,4,ENST00000397752,NM_000245.2,Yes,No MET,Kinase Domain Duplication,Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,T992I,Inconclusive,Inconclusive,4,ENST00000397752,NM_000245.2,Yes,No MET,X1006_splice,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,E168D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,Y1248H,Resistance,Inconclusive,4,ENST00000397752,NM_000245.2,Yes,No MET,V1188L,Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,H1094L,Oncogenic,Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,Y1003*,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,R970C,Inconclusive,Inconclusive,4,ENST00000397752,NM_000245.2,Yes,No MET,R1004A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,Y1003C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,Y1003N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397752,NM_000245.2,Yes,No MET,D1246N,Resistance,Inconclusive,4,ENST00000397752,NM_000245.2,Yes,No DUSP22,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000344450,NM_020185.4,No,Yes H1-3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000244534,NM_005320.2,No,Yes KDM6A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000377967,NM_021140.2,No,Yes SDHD,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000375549,NM_003002.3,No,Yes PRDM1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000369096,NM_001198.3,No,Yes ARID1A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000324856,NM_006015.4,No,Yes NFE2L2,W24R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,I28T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,E79Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,Exon 2 and 3 deletions,Likely Oncogenic,Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,T80R,Likely Oncogenic,Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,V32G,Inconclusive,Inconclusive,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,G31V,Oncogenic,Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,E79K,Likely Oncogenic,Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,D77H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,T80K,Oncogenic,Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,E82D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,G81R,Likely Oncogenic,Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,R34G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,G31R,Oncogenic,Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,D29Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,G81S,Likely Oncogenic,Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,G31A,Oncogenic,Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,D77Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,E82V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,L30P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,D29N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,E82G,Likely Oncogenic,Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,R34L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,G81D,Likely Oncogenic,Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,Exon 2 deletions,Likely Oncogenic,Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,R34Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,D29H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,L30F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,W24C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,T80A,Likely Oncogenic,Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,W24S,Likely Oncogenic,Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,R34P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No NFE2L2,N160S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000397062,NM_006164.4,Yes,No CUX1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000292535,NM_181552.3,No,Yes GNA11,E191G,Likely Neutral,Likely Neutral,4,ENST00000078429,NM_002067.2,Yes,No GNA11,Q209L,Oncogenic,Gain-of-function,4,ENST00000078429,NM_002067.2,Yes,No GNA11,R183C,Oncogenic,Gain-of-function,4,ENST00000078429,NM_002067.2,Yes,No GNA11,E234K,Likely Neutral,Likely Neutral,4,ENST00000078429,NM_002067.2,Yes,No TBL1XR1,F10L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000430069,NM_024665.4,No,Yes YAP1,R331W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000282441,NM_001130145.2,Yes,No HLA-B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000412585,NM_005514.6,No,Yes CRLF2,F232C,Oncogenic,Gain-of-function,4,ENST00000381566,NM_022148.2,Yes,No SH2B3,D231fs,Oncogenic,Likely Loss-of-function,4,ENST00000341259,NM_005475.2,No,Yes SH2B3,E208Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000341259,NM_005475.2,No,Yes SH2B3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000341259,NM_005475.2,No,Yes SH2B3,G220V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000341259,NM_005475.2,No,Yes NSD1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000439151,NM_022455.4,Yes,Yes JAK3,E1106G,Likely Neutral,Likely Neutral,4,ENST00000458235,NM_000215.3,Yes,No JAK3,R403H,Likely Neutral,Likely Neutral,4,ENST00000458235,NM_000215.3,Yes,No JAK3,M511I,Oncogenic,Gain-of-function,4,ENST00000458235,NM_000215.3,Yes,No JAK3,R657Q,Oncogenic,Gain-of-function,4,ENST00000458235,NM_000215.3,Yes,No JAK3,R657W,Oncogenic,Gain-of-function,4,ENST00000458235,NM_000215.3,Yes,No JAK3,A573V,Oncogenic,Gain-of-function,4,ENST00000458235,NM_000215.3,Yes,No JAK3,R272H,Likely Neutral,Likely Neutral,4,ENST00000458235,NM_000215.3,Yes,No JAK3,L857Q,Oncogenic,Gain-of-function,4,ENST00000458235,NM_000215.3,Yes,No JAK3,V678M,Oncogenic,Gain-of-function,4,ENST00000458235,NM_000215.3,Yes,No JAK3,A572T,Oncogenic,Gain-of-function,4,ENST00000458235,NM_000215.3,Yes,No JAK3,R925S,Likely Neutral,Likely Neutral,4,ENST00000458235,NM_000215.3,Yes,No JAK3,V674A,Oncogenic,Gain-of-function,4,ENST00000458235,NM_000215.3,Yes,No PIK3CD,E525K,Likely Oncogenic,Gain-of-function,4,ENST00000377346,NM_005026.3,Yes,No PIK3CD,G124D,Oncogenic,Gain-of-function,4,ENST00000377346,NM_005026.3,Yes,No PIK3CD,N334K,Likely Oncogenic,Gain-of-function,4,ENST00000377346,NM_005026.3,Yes,No PIK3CD,C416R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000377346,NM_005026.3,Yes,No PIK3CD,E1021K,Likely Oncogenic,Gain-of-function,4,ENST00000377346,NM_005026.3,Yes,No PIK3CD,G971R,Oncogenic,Gain-of-function,4,ENST00000377346,NM_005026.3,Yes,No NT5C2,D407H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,D407E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,D407A,Likely Oncogenic,Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,R238Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,R238W,Likely Oncogenic,Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,D407Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,P414S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,K404N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,R238L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,R238G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,D415G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,R478S,Likely Oncogenic,Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,R39Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,L375F,Likely Oncogenic,Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,Q523*,Likely Oncogenic,Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,S408R,Likely Oncogenic,Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,R367Q,Likely Oncogenic,Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,S445F,Likely Oncogenic,Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,P414A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No NT5C2,K359Q,Likely Oncogenic,Gain-of-function,4,ENST00000343289,NM_001134373.2,Yes,No ATXN2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000377617,NM_002973.3,No,Yes ASXL1,G646Wfs*12,Likely Oncogenic,Likely Loss-of-function,4,ENST00000375687,NM_015338.5,No,Yes ASXL1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000375687,NM_015338.5,No,Yes AMER1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000330258,NM_152424.3,No,Yes SH2D1A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371139,NM_002351.4,No,Yes SH2D1A,T53I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371139,NM_002351.4,No,Yes SH2D1A,Q99P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371139,NM_002351.4,No,Yes SH2D1A,R32Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371139,NM_002351.4,No,Yes SH2D1A,C42W,Likely Oncogenic,Loss-of-function,4,ENST00000371139,NM_002351.4,No,Yes SH2D1A,P101L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371139,NM_002351.4,No,Yes SH2D1A,S28R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371139,NM_002351.4,No,Yes SH2D1A,Y7C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371139,NM_002351.4,No,Yes SH2D1A,T68I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371139,NM_002351.4,No,Yes SH2D1A,V102G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371139,NM_002351.4,No,Yes MRE11,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000323929,NM_005591.3,No,Yes MRE11,N117S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000323929,NM_005591.3,No,Yes JAK1,Y652H,Likely Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,K648N,Likely Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,L783F,Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,A634D,Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,A723D,Likely Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,S729C,Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,F958V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,K1026E,Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,F958S,Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,F958C,Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,S646F,Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,R724H,Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,Y1035C,Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,S703I,Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,R879C,Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,G1097D,Likely Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,L910P,Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes JAK1,V658F,Oncogenic,Gain-of-function,4,ENST00000342505,NM_002227.2,Yes,Yes ARHGAP35,R997*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000404338,NM_004491.4,Yes,Yes ARHGAP35,Y742H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000404338,NM_004491.4,Yes,Yes ARHGAP35,L1396Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000404338,NM_004491.4,Yes,Yes ARHGAP35,R997Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000404338,NM_004491.4,Yes,Yes ARHGAP35,R1284A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000404338,NM_004491.4,Yes,Yes ARHGAP35,S866F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000404338,NM_004491.4,Yes,Yes ARHGAP35,R832Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000404338,NM_004491.4,Yes,Yes ARHGAP35,A865_L870del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000404338,NM_004491.4,Yes,Yes GNA13,L197Q,Likely Neutral,Likely Loss-of-function,4,ENST00000439174,NM_006572.5,Yes,No GNA13,I158K,Likely Neutral,Likely Loss-of-function,4,ENST00000439174,NM_006572.5,Yes,No GNA13,N283I,Likely Neutral,Likely Loss-of-function,4,ENST00000439174,NM_006572.5,Yes,No GNA13,D259V,Likely Neutral,Likely Loss-of-function,4,ENST00000439174,NM_006572.5,Yes,No GNA13,Q226L,Likely Oncogenic,Gain-of-function,4,ENST00000439174,NM_006572.5,Yes,No GNA13,Y308S,Likely Neutral,Likely Loss-of-function,4,ENST00000439174,NM_006572.5,Yes,No GNA13,I305S,Likely Neutral,Likely Loss-of-function,4,ENST00000439174,NM_006572.5,Yes,No GNA13,L184R,Likely Neutral,Likely Loss-of-function,4,ENST00000439174,NM_006572.5,Yes,No GNA13,K292R,Likely Neutral,Likely Loss-of-function,4,ENST00000439174,NM_006572.5,Yes,No GNA13,F245S,Likely Neutral,Likely Loss-of-function,4,ENST00000439174,NM_006572.5,Yes,No PTPN1,M282L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371621,NM_001278618.1,Yes,Yes PTPN1,Q9*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371621,NM_001278618.1,Yes,Yes PTPN1,R156*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371621,NM_001278618.1,Yes,Yes PTPN1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371621,NM_001278618.1,Yes,Yes PTPN1,V184D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371621,NM_001278618.1,Yes,Yes PTPN1,M74L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371621,NM_001278618.1,Yes,Yes PTPN1,A69V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000371621,NM_001278618.1,Yes,Yes CDKN1B,G9R,Likely Oncogenic,Loss-of-function,4,ENST00000228872,NM_004064.3,No,Yes CDKN1B,P133T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000228872,NM_004064.3,No,Yes CDKN1B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000228872,NM_004064.3,No,Yes CDKN1B,V109G,Inconclusive,Inconclusive,4,ENST00000228872,NM_004064.3,No,Yes PAK5,S312C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000353224,NM_177990.2,Yes,No PAK5,S573N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000353224,NM_177990.2,Yes,No PAK5,V593I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000353224,NM_177990.2,Yes,No PAK5,E294K,Likely Neutral,Likely Neutral,4,ENST00000353224,NM_177990.2,Yes,No PAK5,T538N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000353224,NM_177990.2,Yes,No PAK5,M173I,Likely Neutral,Likely Neutral,4,ENST00000353224,NM_177990.2,Yes,No PAK5,S364L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000353224,NM_177990.2,Yes,No PAK5,V463L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000353224,NM_177990.2,Yes,No PAK5,E144K,Likely Neutral,Likely Neutral,4,ENST00000353224,NM_177990.2,Yes,No PAK5,D421N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000353224,NM_177990.2,Yes,No SMO,W281C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000249373,NM_005631.4,Yes,No SMO,T241M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000249373,NM_005631.4,Yes,No SMO,L221R,Inconclusive,Inconclusive,4,ENST00000249373,NM_005631.4,Yes,No SMO,I408V,Likely Oncogenic,Gain-of-function,4,ENST00000249373,NM_005631.4,Yes,No SMO,C469Y,Likely Oncogenic,Gain-of-function,4,ENST00000249373,NM_005631.4,Yes,No SMO,S387N,Likely Oncogenic,Gain-of-function,4,ENST00000249373,NM_005631.4,Yes,No SMO,K575M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000249373,NM_005631.4,Yes,No SMO,V321M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000249373,NM_005631.4,Yes,No SMO,D473H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000249373,NM_005631.4,Yes,No SMO,V414A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000249373,NM_005631.4,Yes,No SMO,L412F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000249373,NM_005631.4,Yes,No SMO,F460L,Likely Oncogenic,Gain-of-function,4,ENST00000249373,NM_005631.4,Yes,No SMO,W535L,Likely Oncogenic,Gain-of-function,4,ENST00000249373,NM_005631.4,Yes,No SMO,N219D,Inconclusive,Inconclusive,4,ENST00000249373,NM_005631.4,Yes,No SMO,E518K,Likely Neutral,Likely Neutral,4,ENST00000249373,NM_005631.4,Yes,No SMO,Q635E,Inconclusive,Inconclusive,4,ENST00000249373,NM_005631.4,Yes,No SMO,E518A,Resistance,Inconclusive,4,ENST00000249373,NM_005631.4,Yes,No SMO,D473G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000249373,NM_005631.4,Yes,No SMO,Q477E,Inconclusive,Inconclusive,4,ENST00000249373,NM_005631.4,Yes,No SMO,D384N,Inconclusive,Inconclusive,4,ENST00000249373,NM_005631.4,Yes,No SMO,D473Y,Resistance,Inconclusive,4,ENST00000249373,NM_005631.4,Yes,No SMO,H231R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000249373,NM_005631.4,Yes,No SMO,A459V,Likely Oncogenic,Gain-of-function,4,ENST00000249373,NM_005631.4,Yes,No TNFAIP3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000237289,NM_006290.3,No,Yes ABRAXAS1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000321945,NM_139076.2,No,Yes ARID1B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000346085,NM_020732.3,No,Yes HLA-A,596_619splice,Likely Oncogenic,Likely Loss-of-function,4,ENST00000376809,NM_001242758.1,No,Yes HLA-A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000376809,NM_001242758.1,No,Yes BCL2,A131T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000333681,NM_000633.2,Yes,No BCL2,K22R,Likely Neutral,Likely Neutral,4,ENST00000333681,NM_000633.2,Yes,No BCL2,P59S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000333681,NM_000633.2,Yes,No BCL2,N172Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000333681,NM_000633.2,Yes,No BCL2,G33R,Likely Oncogenic,Gain-of-function,4,ENST00000333681,NM_000633.2,Yes,No BCL2,G101V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000333681,NM_000633.2,Yes,No BCL2,N172S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000333681,NM_000633.2,Yes,No NFKBIA,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000216797,NM_020529.2,No,Yes NFKBIA,S36Y,Likely Neutral,Likely Gain-of-function,4,ENST00000216797,NM_020529.2,No,Yes NFKBIA,E14*,Likely Neutral,Gain-of-function,4,ENST00000216797,NM_020529.2,No,Yes NFKBIA,M37K,Likely Neutral,Likely Gain-of-function,4,ENST00000216797,NM_020529.2,No,Yes NFKBIA,L34P,Likely Neutral,Likely Gain-of-function,4,ENST00000216797,NM_020529.2,No,Yes NFKBIA,S32I,Likely Neutral,Gain-of-function,4,ENST00000216797,NM_020529.2,No,Yes FOXO1,S22P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379561,NM_002015.3,No,Yes FOXO1,L219A,Likely Neutral,Likely Neutral,4,ENST00000379561,NM_002015.3,No,Yes FOXO1,T24A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379561,NM_002015.3,No,Yes FOXO1,L217A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379561,NM_002015.3,No,Yes FOXO1,L183P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379561,NM_002015.3,No,Yes FOXO1,N216A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379561,NM_002015.3,No,Yes FOXO1,S205N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379561,NM_002015.3,No,Yes FOXO1,L168V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379561,NM_002015.3,No,Yes FOXO1,R214A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379561,NM_002015.3,No,Yes FOXO1,M1L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379561,NM_002015.3,No,Yes FOXO1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379561,NM_002015.3,No,Yes FOXO1,N216K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379561,NM_002015.3,No,Yes FOXO1,T24I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379561,NM_002015.3,No,Yes FOXO1,I213A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379561,NM_002015.3,No,Yes FOXO1,A166V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379561,NM_002015.3,No,Yes FOXO1,H215A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379561,NM_002015.3,No,Yes FOXO1,I186T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000379561,NM_002015.3,No,Yes NSD2,E1099K,Oncogenic,Gain-of-function,4,ENST00000382891,NM_001042424.2,Yes,No SPRTN,E112A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000295050,NM_032018.6,No,Yes SPRTN,Y117C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000295050,NM_032018.6,No,Yes KRAS,Q61L,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Y71H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,E63K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,E62K,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Q22E,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,N116H,Inconclusive,Inconclusive,4,ENST00000311936,NM_004985.3,Yes,No KRAS,K117N,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,F156L,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,M67L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,K5N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G12R,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G12C,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Q25H,Inconclusive,Inconclusive,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Q22R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Y64D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Q61K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,R164Q,Inconclusive,Inconclusive,4,ENST00000311936,NM_004985.3,Yes,No KRAS,R149G,Inconclusive,Inconclusive,4,ENST00000311936,NM_004985.3,Yes,No KRAS,A59G,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Q61E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G13R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G60E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,D33E,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Y40A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,E31K,Likely Neutral,Likely Neutral,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Q61R,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Q61A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,P34L,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,M67R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,K117D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,A59T,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,V14I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G12L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,D153V,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,S65N,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G12V,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Y64A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G12W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,A59E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G12D,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,A18D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G12A,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Q22K,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,E31D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Q61P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G60R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,L19F,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,K147E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G12S,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,T74P,Likely Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Y96D,Resistance,Inconclusive,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G60D,Inconclusive,Inconclusive,4,ENST00000311936,NM_004985.3,Yes,No KRAS,T58I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,C118S,Likely Neutral,Likely Loss-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G13V,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,F28L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,A11_G12insGA,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G13C,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,E62_A66dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,A146V,Likely Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G13D,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,A146T,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Y32S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Wildtype,Likely Neutral,Neutral,4,ENST00000311936,NM_004985.3,Yes,No KRAS,Q61H,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G60_A66dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,P34R,Oncogenic,Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,A146P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G12F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,D119N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G13E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No KRAS,G10dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311936,NM_004985.3,Yes,No TYK2,S47N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000264818,NM_003331.4,Yes,No TYK2,V731I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000264818,NM_003331.4,Yes,No TYK2,E957D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000264818,NM_003331.4,Yes,No TYK2,R1027H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000264818,NM_003331.4,Yes,No TYK2,R425H,Likely Neutral,Likely Neutral,4,ENST00000264818,NM_003331.4,Yes,No TYK2,G36D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000264818,NM_003331.4,Yes,No KLF2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000248071,NM_016270.2,No,Yes KLF2,C274Y,Oncogenic,Likely Loss-of-function,4,ENST00000248071,NM_016270.2,No,Yes KLF2,A291V,Likely Neutral,Likely Neutral,4,ENST00000248071,NM_016270.2,No,Yes IGF1R,M1255I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000268035,NM_000875.3,Yes,No IGF1R,A1347V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000268035,NM_000875.3,Yes,No IGF1R,R10L,Likely Oncogenic,Loss-of-function,4,ENST00000268035,NM_000875.3,Yes,No DDX3X,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000399959,NM_001356.4,No,Yes DDX3X,Y38A,Likely Oncogenic,Loss-of-function,4,ENST00000399959,NM_001356.4,No,Yes DDX3X,D354V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000399959,NM_001356.4,No,Yes DDX3X,L43A,Likely Oncogenic,Loss-of-function,4,ENST00000399959,NM_001356.4,No,Yes DDX3X,G302V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000399959,NM_001356.4,No,Yes DDX3X,M370R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000399959,NM_001356.4,No,Yes DDX3X,A222P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000399959,NM_001356.4,No,Yes DDX3X,R351W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000399959,NM_001356.4,No,Yes DDX3X,G325E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000399959,NM_001356.4,No,Yes DDX3X,T275M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000399959,NM_001356.4,No,Yes DDX3X,L353F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000399959,NM_001356.4,No,Yes RAB35,A151T,Oncogenic,Gain-of-function,4,ENST00000229340,NM_006861.6,Yes,No RAB35,F161L,Oncogenic,Gain-of-function,4,ENST00000229340,NM_006861.6,Yes,No CTLA4,T17A,Inconclusive,Inconclusive,4,ENST00000302823,NM_005214.4,Yes,No RHEB,G63A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262187,NM_005614.3,Yes,No RHEB,Y35C,Oncogenic,Gain-of-function,4,ENST00000262187,NM_005614.3,Yes,No RHEB,Y35H,Likely Oncogenic,Gain-of-function,4,ENST00000262187,NM_005614.3,Yes,No RHEB,P37L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262187,NM_005614.3,Yes,No RHEB,Y35N,Oncogenic,Gain-of-function,4,ENST00000262187,NM_005614.3,Yes,No RHEB,E40V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000262187,NM_005614.3,Yes,No LRP5,A214T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000294304,NM_001291902.1,Yes,Yes LRP5,E721A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000294304,NM_001291902.1,Yes,Yes LRP5,W199A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000294304,NM_001291902.1,Yes,Yes LRP5,D111Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000294304,NM_001291902.1,Yes,Yes LRP5,G171V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000294304,NM_001291902.1,Yes,Yes LRP5,T253I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000294304,NM_001291902.1,Yes,Yes LRP5,N198S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000294304,NM_001291902.1,Yes,Yes LRP5,R154M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000294304,NM_001291902.1,Yes,Yes SLFN11,E669Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000308377,NM_001104587.1,No,Yes RRAS2,Q72L,Oncogenic,Gain-of-function,4,ENST00000256196,NM_012250.5,Yes,No RRAS2,G24D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000256196,NM_012250.5,Yes,No RRAS2,G23V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000256196,NM_012250.5,Yes,No GPS2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380728,NM_004489.4,No,Yes IL7R,S185C,Oncogenic,Gain-of-function,4,ENST00000303115,NM_002185.3,Yes,No IL7R,T244_I245insCPT,Oncogenic,Gain-of-function,4,ENST00000303115,NM_002185.3,Yes,No STAT2,R510*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000314128,NM_005419.3,No,No KMT2C,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262189,NM_170606.2,No,Yes KMT2C,A1685S,Likely Oncogenic,Loss-of-function,4,ENST00000262189,NM_170606.2,No,Yes KMT2C,S3660L,Likely Neutral,Likely Neutral,4,ENST00000262189,NM_170606.2,No,Yes KMT2B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000222270,NM_014727.1,No,Yes MAX,R35L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358664,NM_002382.4,No,Yes MAX,R60Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358664,NM_002382.4,No,Yes MAX,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358664,NM_002382.4,No,Yes MAX,R60W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358664,NM_002382.4,No,Yes MAX,R35H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358664,NM_002382.4,No,Yes MAX,R36W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358664,NM_002382.4,No,Yes MAX,H28R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358664,NM_002382.4,No,Yes HOXB13,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000290295,NM_006361.5,Yes,Yes HOXB13,G84E,Inconclusive,Inconclusive,4,ENST00000290295,NM_006361.5,Yes,Yes TCF3,V557E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000344749,NM_001136139.2,No,Yes TCF3,D561E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000344749,NM_001136139.2,No,Yes TCF3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000344749,NM_001136139.2,No,Yes TCF3,N551K,Likely Oncogenic,Loss-of-function,4,ENST00000344749,NM_001136139.2,No,Yes GNAS,R201C,Oncogenic,Gain-of-function,4,ENST00000371085,NM_000516.4,Yes,No GNAS,R201H,Oncogenic,Gain-of-function,4,ENST00000371085,NM_000516.4,Yes,No GNAS,Q227L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000371085,NM_000516.4,Yes,No GNAS,Q227R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000371085,NM_000516.4,Yes,No GNAS,R160C,Likely Oncogenic,Inconclusive,4,ENST00000371085,NM_000516.4,Yes,No CBL,N454D,Likely Neutral,Neutral,4,ENST00000264033,NM_005188.3,No,Yes CBL,P417A,Likely Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,H94Y,Inconclusive,Inconclusive,4,ENST00000264033,NM_005188.3,No,Yes CBL,W802*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,C384R,Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,Q367P,Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,D390Y,Likely Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,V391I,Likely Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,Y371S,Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,H398Y,Likely Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,V430M,Likely Neutral,Likely Neutral,4,ENST00000264033,NM_005188.3,No,Yes CBL,C381A,Likely Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,K382E,Likely Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,H398Q,Likely Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,S80N,Inconclusive,Inconclusive,4,ENST00000264033,NM_005188.3,No,Yes CBL,S376F,Likely Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,P395A,Likely Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,Y371H,Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,C396R,Likely Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,R420Q,Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,L399V,Likely Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,Q249E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes CBL,M374V,Likely Neutral,Likely Neutral,4,ENST00000264033,NM_005188.3,No,Yes CBL,P428L,Likely Neutral,Likely Neutral,4,ENST00000264033,NM_005188.3,No,Yes CBL,G375P,Likely Oncogenic,Loss-of-function,4,ENST00000264033,NM_005188.3,No,Yes STAT3,F384Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000264657,NM_139276.2,Yes,No STAT3,E616G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000264657,NM_139276.2,Yes,No STAT3,E616K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000264657,NM_139276.2,Yes,No STAT3,K658N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000264657,NM_139276.2,Yes,No STAT3,F384L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000264657,NM_139276.2,Yes,No STAT3,C426R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000264657,NM_139276.2,Yes,No STAT3,D661Y,Likely Oncogenic,Gain-of-function,4,ENST00000264657,NM_139276.2,Yes,No STAT3,G618R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000264657,NM_139276.2,Yes,No STAT3,N647I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000264657,NM_139276.2,Yes,No STAT3,E616del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000264657,NM_139276.2,Yes,No STAT3,H410R,Likely Oncogenic,Gain-of-function,4,ENST00000264657,NM_139276.2,Yes,No STAT3,D661V,Likely Oncogenic,Gain-of-function,4,ENST00000264657,NM_139276.2,Yes,No STAT3,Y640F,Oncogenic,Gain-of-function,4,ENST00000264657,NM_139276.2,Yes,No STAT3,D427H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000264657,NM_139276.2,Yes,No STAT3,F384V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000264657,NM_139276.2,Yes,No STAT3,S614R,Likely Oncogenic,Gain-of-function,4,ENST00000264657,NM_139276.2,Yes,No FH,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000366560,NM_000143.3,No,Yes FH,K477dup,Inconclusive,Inconclusive,4,ENST00000366560,NM_000143.3,No,Yes FH,Y465C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000366560,NM_000143.3,No,Yes FH,T330P,Inconclusive,Inconclusive,4,ENST00000366560,NM_000143.3,No,Yes FH,G397R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000366560,NM_000143.3,No,Yes FH,M195T,Inconclusive,Inconclusive,4,ENST00000366560,NM_000143.3,No,Yes FH,S186N,Inconclusive,Inconclusive,4,ENST00000366560,NM_000143.3,No,Yes PLCG1,S520F,Likely Oncogenic,Gain-of-function,4,ENST00000373271,NM_182811.1,Yes,No PLCG1,S345F,Likely Oncogenic,Gain-of-function,4,ENST00000373271,NM_182811.1,Yes,No PLCG1,R707Q,Likely Oncogenic,Gain-of-function,4,ENST00000373271,NM_182811.1,Yes,No NADK,I90F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000341426,NM_001198993.1,Yes,No RB1,C712R,Likely Neutral,Likely Neutral,4,ENST00000267163,NM_000321.2,No,Yes RB1,S567L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000267163,NM_000321.2,No,Yes RB1,R621C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000267163,NM_000321.2,No,Yes RB1,N480del,Likely Neutral,Likely Neutral,4,ENST00000267163,NM_000321.2,No,Yes RB1,C706F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000267163,NM_000321.2,No,Yes RB1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000267163,NM_000321.2,No,Yes RB1,L607I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000267163,NM_000321.2,No,Yes RB1,R661W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000267163,NM_000321.2,No,Yes RB1,R698W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000267163,NM_000321.2,No,Yes LRP6,Y875A,Likely Neutral,Likely Loss-of-function,4,ENST00000261349,NM_002336.2,Yes,No LRP6,Y706A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000261349,NM_002336.2,Yes,No LRP6,S488Y,Likely Neutral,Likely Loss-of-function,4,ENST00000261349,NM_002336.2,Yes,No LRP6,E708A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000261349,NM_002336.2,Yes,No LRP6,R1184A,Likely Neutral,Likely Loss-of-function,4,ENST00000261349,NM_002336.2,Yes,No LRP6,R118A,Likely Neutral,Likely Loss-of-function,4,ENST00000261349,NM_002336.2,Yes,No LRP6,P1206H,Likely Neutral,Likely Loss-of-function,4,ENST00000261349,NM_002336.2,Yes,No LRP6,R739G,Likely Neutral,Likely Loss-of-function,4,ENST00000261349,NM_002336.2,Yes,No LRP6,W767A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000261349,NM_002336.2,Yes,No LRP6,K82N,Likely Neutral,Likely Loss-of-function,4,ENST00000261349,NM_002336.2,Yes,No LRP6,E663A,Likely Neutral,Likely Loss-of-function,4,ENST00000261349,NM_002336.2,Yes,No LRP6,M877A,Likely Neutral,Likely Loss-of-function,4,ENST00000261349,NM_002336.2,Yes,No LRP6,I1264V,Likely Neutral,Likely Loss-of-function,4,ENST00000261349,NM_002336.2,Yes,No LRP6,P1066T,Likely Neutral,Likely Loss-of-function,4,ENST00000261349,NM_002336.2,Yes,No PPP2R2A,E83*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000380737,NM_002717.3,No,Yes SF3B1,R625H,Likely Oncogenic,Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,R625D,Likely Oncogenic,Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,R625G,Likely Oncogenic,Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,K700E,Likely Oncogenic,Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,K666N,Likely Oncogenic,Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,K666T,Likely Oncogenic,Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,R625C,Likely Oncogenic,Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,Y623C,Inconclusive,Inconclusive,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,G742D,Likely Oncogenic,Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,K741Q,Likely Oncogenic,Likely Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,G740E,Likely Oncogenic,Likely Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,R957Q,Likely Oncogenic,Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,I665F,Likely Neutral,Likely Neutral,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,D781E,Likely Oncogenic,Likely Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,R625L,Likely Oncogenic,Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,H662Q,Likely Oncogenic,Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,E622Q,Inconclusive,Inconclusive,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,H662R,Likely Oncogenic,Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,H662D,Likely Oncogenic,Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,K700R,Likely Oncogenic,Likely Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,K741E,Likely Oncogenic,Likely Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,K666R,Oncogenic,Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,K666M,Likely Oncogenic,Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,E622D,Likely Oncogenic,Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No SF3B1,K741N,Likely Oncogenic,Likely Switch-of-function,4,ENST00000335508,NM_012433.2,Yes,No STAT1,K278E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361099,NM_007315.3,No,No STAT1,Y701C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000361099,NM_007315.3,No,No STAT1,K673R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000361099,NM_007315.3,No,No STAT1,G250E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000361099,NM_007315.3,No,No STAT1,T437N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361099,NM_007315.3,No,No STAT1,G384D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361099,NM_007315.3,No,No STAT1,R274Q,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361099,NM_007315.3,No,No STAT1,T437I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361099,NM_007315.3,No,No STAT1,Q463H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000361099,NM_007315.3,No,No STAT1,T385M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361099,NM_007315.3,No,No STAT1,E157K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000361099,NM_007315.3,No,No GNAQ,T175R,Likely Neutral,Likely Neutral,4,ENST00000286548,NM_002072.3,Yes,No GNAQ,G48L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000286548,NM_002072.3,Yes,No GNAQ,Q209L,Oncogenic,Gain-of-function,4,ENST00000286548,NM_002072.3,Yes,No GNAQ,T96S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000286548,NM_002072.3,Yes,No GNAQ,F228L,Likely Neutral,Likely Neutral,4,ENST00000286548,NM_002072.3,Yes,No GNAQ,R183Q,Likely Neutral,Likely Neutral,4,ENST00000286548,NM_002072.3,Yes,No GNAQ,Q209P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000286548,NM_002072.3,Yes,No GNAQ,G48V,Likely Neutral,Likely Neutral,4,ENST00000286548,NM_002072.3,Yes,No TOP1,T729E,Resistance,Likely Loss-of-function,4,ENST00000361337,NM_003286.2,Yes,No TOP1,F361S,Resistance,Inconclusive,4,ENST00000361337,NM_003286.2,Yes,No TOP1,E710G,Likely Neutral,Likely Neutral,4,ENST00000361337,NM_003286.2,Yes,No TOP1,G365S,Resistance,Likely Loss-of-function,4,ENST00000361337,NM_003286.2,Yes,No TOP1,D533G,Resistance,Inconclusive,4,ENST00000361337,NM_003286.2,Yes,No TOP1,G717R,Resistance,Likely Loss-of-function,4,ENST00000361337,NM_003286.2,Yes,No TOP1,N722S,Resistance,Inconclusive,4,ENST00000361337,NM_003286.2,Yes,No TOP1,R621H,Likely Neutral,Likely Neutral,4,ENST00000361337,NM_003286.2,Yes,No TOP1,W736*,Resistance,Likely Loss-of-function,4,ENST00000361337,NM_003286.2,Yes,No TOP1,A653P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361337,NM_003286.2,Yes,No TOP1,D583G,Resistance,Inconclusive,4,ENST00000361337,NM_003286.2,Yes,No TOP1,G737S,Resistance,Inconclusive,4,ENST00000361337,NM_003286.2,Yes,No TOP1,T729K,Resistance,Inconclusive,4,ENST00000361337,NM_003286.2,Yes,No TOP1,Y723F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000361337,NM_003286.2,Yes,No TOP1,Q421R,Resistance,Likely Loss-of-function,4,ENST00000361337,NM_003286.2,Yes,No TOP1,G363C,Resistance,Inconclusive,4,ENST00000361337,NM_003286.2,Yes,No TOP1,R364H,Resistance,Inconclusive,4,ENST00000361337,NM_003286.2,Yes,No TOP1,T729A,Resistance,Likely Loss-of-function,4,ENST00000361337,NM_003286.2,Yes,No TOP1,L617I,Likely Neutral,Likely Neutral,4,ENST00000361337,NM_003286.2,Yes,No TOP1,E418K,Resistance,Inconclusive,4,ENST00000361337,NM_003286.2,Yes,No KMT2A,Partial Tandem Duplication,Likely Oncogenic,Likely Gain-of-function,4,ENST00000534358,NM_001197104.1,No,Yes KMT2A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000534358,NM_001197104.1,No,Yes KNSTRN,A40E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000249776,NM_033286.3,No,No KNSTRN,V12G,Inconclusive,Inconclusive,4,ENST00000249776,NM_033286.3,No,No KNSTRN,P26S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000249776,NM_033286.3,No,No KNSTRN,R11K,Likely Oncogenic,Likely Loss-of-function,4,ENST00000249776,NM_033286.3,No,No KNSTRN,S24F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000249776,NM_033286.3,No,No KNSTRN,P28S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000249776,NM_033286.3,No,No IKZF3,Q147H,Likely Oncogenic,Likely Gain-of-function,4,ENST00000346872,NM_012481.4,Yes,Yes CYSLTR2,L129Q,Likely Oncogenic,Gain-of-function,4,ENST00000282018,NM_020377.2,Yes,No RUNX1,R166G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,W279*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,K110N,Likely Oncogenic,Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,S318fsX300,Oncogenic,Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,Y140*,Oncogenic,Likely Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,R107C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,P200S,Oncogenic,Likely Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,H105Q,Likely Oncogenic,Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,D198N,Oncogenic,Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,A149*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,R204Q,Oncogenic,Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,R201Q,Oncogenic,Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,K110E,Likely Oncogenic,Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,R166Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,R204*,Oncogenic,Likely Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,D198G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,R201*,Oncogenic,Gain-of-function,4,ENST00000300305,NM_001754.4,No,Yes RUNX1,G69R,Inconclusive,Inconclusive,4,ENST00000300305,NM_001754.4,No,Yes AGO2,R583A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000220592,NM_012154.3,No,No AGO2,R812A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000220592,NM_012154.3,No,No AGO2,Q545A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000220592,NM_012154.3,No,No AGO2,R647A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000220592,NM_012154.3,No,No PLCG2,R665W,Oncogenic,Gain-of-function,4,ENST00000359376,NM_002661.3,Yes,No PLCG2,L845F,Oncogenic,Gain-of-function,4,ENST00000359376,NM_002661.3,Yes,No SFRP1,C140Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000220772,NM_003012.4,No,Yes MYH11,R669C,Inconclusive,Inconclusive,4,ENST00000300036,NM_002474,No,Yes MYH11,K1256del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000300036,NM_002474,No,Yes MYH11,R669H,Inconclusive,Inconclusive,4,ENST00000300036,NM_002474,No,Yes ROBO1,R922H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000464233,NM_002941.3,No,Yes ROBO1,R107H,Likely Neutral,Likely Neutral,4,ENST00000464233,NM_002941.3,No,Yes ROBO1,T1260A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000464233,NM_002941.3,No,Yes SMAD4,G491fs,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,W398V,Inconclusive,Inconclusive,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,R361H,Likely Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,Y413_R416del,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,C324Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,L43V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,E33*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,R497H,Likely Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,Y513A,Inconclusive,Inconclusive,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,G86V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,D493A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,R515I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,D537Y,Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,V465M,Inconclusive,Inconclusive,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,K507Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,R361C,Likely Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,G419V,Likely Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,D351N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,P130S,Likely Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,V370D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,R420H,Likely Oncogenic,Likely Neutral,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,Y353L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,A532H,Likely Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,E330K,Likely Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,E330G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,R378A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,G386D,Likely Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,D537G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,H132Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,D351H,Likely Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,K507A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,G508S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,D493H,Likely Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,D537A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,W302*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,D537V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,D537E,Likely Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,R515G,Likely Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,G352E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,R496H,Likely Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,P102L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,E330A,Likely Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,R361G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,E526Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,R100T,Likely Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,D537H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,L109fs,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,G510R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,Y353S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,K428A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,F408fs,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,R441P,Likely Neutral,Likely Neutral,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,D493G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,D493N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,R515A,Likely Oncogenic,Loss-of-function,4,ENST00000342988,NM_005359.5,No,Yes SMAD4,W509R,Inconclusive,Inconclusive,4,ENST00000342988,NM_005359.5,No,Yes CDH1,A298T,Likely Oncogenic,Likely Loss-of-function,4,ENST00000261769,NM_004360.3,No,Yes CDH1,D254N,Oncogenic,Loss-of-function,4,ENST00000261769,NM_004360.3,No,Yes CDH1,A634V,Oncogenic,Loss-of-function,4,ENST00000261769,NM_004360.3,No,Yes CDH1,T340A,Oncogenic,Loss-of-function,4,ENST00000261769,NM_004360.3,No,Yes CDH1,A617T,Likely Oncogenic,Loss-of-function,4,ENST00000261769,NM_004360.3,No,Yes CDH1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000261769,NM_004360.3,No,Yes CDH1,D257N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000261769,NM_004360.3,No,Yes CDH1,G239R,Inconclusive,Inconclusive,4,ENST00000261769,NM_004360.3,No,Yes CDH1,Epigenetic Silencing,Likely Oncogenic,Likely Loss-of-function,4,ENST00000261769,NM_004360.3,No,Yes CDH1,R732Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000261769,NM_004360.3,No,Yes NCOR1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000268712,NM_006311.3,No,Yes GRIN2A,G762E,Inconclusive,Inconclusive,4,ENST00000330684,NM_001134407.1,No,Yes GRIN2A,P1132L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000330684,NM_001134407.1,No,Yes GRIN2A,P1133S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000330684,NM_001134407.1,No,Yes GRIN2A,G889E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000330684,NM_001134407.1,No,Yes GRIN2A,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000330684,NM_001134407.1,No,Yes DDR2,L63V,Oncogenic,Gain-of-function,4,ENST00000367921,NM_006182.2,Yes,No DDR2,S768R,Inconclusive,Inconclusive,4,ENST00000367921,NM_006182.2,Yes,No DDR2,G505S,Likely Oncogenic,Gain-of-function,4,ENST00000367921,NM_006182.2,Yes,No DDR2,T654M,Inconclusive,Inconclusive,4,ENST00000367921,NM_006182.2,Yes,No DDR2,I638F,Inconclusive,Inconclusive,4,ENST00000367921,NM_006182.2,Yes,No DDR2,G774V,Oncogenic,Gain-of-function,4,ENST00000367921,NM_006182.2,Yes,No DDR2,L239R,Oncogenic,Gain-of-function,4,ENST00000367921,NM_006182.2,Yes,No DDR2,T654I,Inconclusive,Inconclusive,4,ENST00000367921,NM_006182.2,Yes,No DDR2,G253C,Oncogenic,Gain-of-function,4,ENST00000367921,NM_006182.2,Yes,No SLX4,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000294008,NM_032444.2,No,Yes SPEN,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000375759,NM_015001.2,No,Yes PREX2,T994A,Likely Neutral,Likely Neutral,4,ENST00000288368,NM_024870.2,No,No PREX2,Q1430*,Likely Oncogenic,Gain-of-function,4,ENST00000288368,NM_024870.2,No,No PREX2,L50V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288368,NM_024870.2,No,No PREX2,P948S,Likely Neutral,Neutral,4,ENST00000288368,NM_024870.2,No,No PREX2,V1441F,Likely Neutral,Likely Neutral,4,ENST00000288368,NM_024870.2,No,No PREX2,A1376V,Likely Neutral,Likely Neutral,4,ENST00000288368,NM_024870.2,No,No PREX2,S1113R,Likely Oncogenic,Gain-of-function,4,ENST00000288368,NM_024870.2,No,No PREX2,K278*,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288368,NM_024870.2,No,No PREX2,G258V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288368,NM_024870.2,No,No PREX2,K400*,Likely Neutral,Likely Loss-of-function,4,ENST00000288368,NM_024870.2,No,No PREX2,E1346D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288368,NM_024870.2,No,No PREX2,P1145S,Likely Neutral,Likely Neutral,4,ENST00000288368,NM_024870.2,No,No PREX2,E824*,Likely Oncogenic,Gain-of-function,4,ENST00000288368,NM_024870.2,No,No PREX2,G844D,Likely Oncogenic,Likely Gain-of-function,4,ENST00000288368,NM_024870.2,No,No PREX2,G106E,Likely Neutral,Likely Neutral,4,ENST00000288368,NM_024870.2,No,No PREX2,T868I,Likely Neutral,Likely Neutral,4,ENST00000288368,NM_024870.2,No,No AKT1,W80A,Likely Oncogenic,Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,F55Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,N53A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,T195I,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,Y176F,Likely Neutral,Likely Loss-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,D323Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,C77F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,T34N,Inconclusive,Inconclusive,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,V270A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,P42T,Likely Neutral,Likely Neutral,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,E17K,Oncogenic,Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,K189N,Inconclusive,Inconclusive,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,L78T,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,D32Y,Likely Neutral,Likely Neutral,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,P68_C77dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,G311D,Inconclusive,Inconclusive,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,K179M,Inconclusive,Inconclusive,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,T65_I75dup,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,Q79K,Oncogenic,Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,L362R,Likely Neutral,Likely Neutral,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,L321A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,D325A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,E191A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,R200A,Likely Neutral,Likely Neutral,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,L202F,Likely Neutral,Likely Neutral,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,K39N,Likely Neutral,Likely Neutral,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,R328A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,R23A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,V271A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,D323H,Oncogenic,Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,Q59E,Likely Neutral,Likely Neutral,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,E40K,Oncogenic,Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,E49K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,F35L,Likely Neutral,Likely Neutral,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,Q79E,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,N53H,Likely Neutral,Likely Neutral,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,R121W,Likely Neutral,Likely Neutral,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,L52R,Oncogenic,Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,E267G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No AKT1,R370C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000349310,NM_001014431.1,Yes,No BARD1,C71Y,Oncogenic,Likely Loss-of-function,4,ENST00000260947,NM_000465.2,No,Yes BARD1,R99E,Likely Oncogenic,Loss-of-function,4,ENST00000260947,NM_000465.2,No,Yes BARD1,C78S,Likely Neutral,Likely Neutral,4,ENST00000260947,NM_000465.2,No,Yes BARD1,C83R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000260947,NM_000465.2,No,Yes BARD1,L44R,Likely Oncogenic,Loss-of-function,4,ENST00000260947,NM_000465.2,No,Yes BARD1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000260947,NM_000465.2,No,Yes BARD1,C53W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000260947,NM_000465.2,No,Yes SOS1,R1051G,Likely Neutral,Likely Neutral,4,ENST00000402219,NM_005633.3,Yes,No SOS1,D309Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000402219,NM_005633.3,Yes,No SOS1,N535S,Likely Neutral,Likely Neutral,4,ENST00000402219,NM_005633.3,Yes,No SOS1,I733V,Likely Neutral,Likely Neutral,4,ENST00000402219,NM_005633.3,Yes,No SOS1,R552G,Likely Oncogenic,Gain-of-function,4,ENST00000402219,NM_005633.3,Yes,No SOS1,I327T,Likely Neutral,Likely Neutral,4,ENST00000402219,NM_005633.3,Yes,No SOS1,G434R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000402219,NM_005633.3,Yes,No SOS1,N233Y,Oncogenic,Gain-of-function,4,ENST00000402219,NM_005633.3,Yes,No SOS1,E846K,Likely Oncogenic,Gain-of-function,4,ENST00000402219,NM_005633.3,Yes,No SOS1,P478L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000402219,NM_005633.3,Yes,No SOS1,R552S,Likely Oncogenic,Gain-of-function,4,ENST00000402219,NM_005633.3,Yes,No SOS1,D265N,Likely Neutral,Likely Neutral,4,ENST00000402219,NM_005633.3,Yes,No SOS1,M269R,Likely Oncogenic,Gain-of-function,4,ENST00000402219,NM_005633.3,Yes,No SOS1,G604V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000402219,NM_005633.3,Yes,No SOS1,L938F,Likely Neutral,Likely Neutral,4,ENST00000402219,NM_005633.3,Yes,No TSC2,V241del,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,E1679K,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,V1144M,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,E114K,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,V705M,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,G661V,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,N1522S,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,E498K,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,G661R,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,S1653P,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,R905Q,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,R245H,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,E254K,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,S1207I,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,N958S,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,V705E,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,L410R,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,A889P,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,L448P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,V1673F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,P1709L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,V1120E,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,T1203K,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,P1771L,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,L1750Afs25,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,P670L,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,S1498N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,S235N,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,D1734E,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,L493P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,A328P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,V1673D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,S1379L,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,Y1571N,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,P1145L,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,R611Q,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,L146R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,P1315S,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,R611W,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,R462C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,L826P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,W1610G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,G654C,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,S918C,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,R505Q,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,V1144L,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,A772E,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,L1584R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,P1675L,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,E1552del,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,V1500M,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,Y1033H,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,V299G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,G1567D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,Q1554H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,M649T,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,P91L,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,P1381L,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,A614D,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,I427M,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,L493V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,T1623I,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,S433C,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,H1773P,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,F615S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,C696Y,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,V769E,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,H597Y,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,S1653F,Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,Y598C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,S1036P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,R1200W,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,S1774T,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,A447V,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,Q1503P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,R905W,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,H522Y,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,G1596V,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,L830R,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,L844R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,E75G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,D416Y,Inconclusive,Inconclusive,4,ENST00000219476,NM_000548.3,No,Yes TSC2,P1358L,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,R905G,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,L792R,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,R1706C,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,H1620R,Likely Oncogenic,Loss-of-function,4,ENST00000219476,NM_000548.3,No,Yes TSC2,V1711M,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes TSC2,S1454G,Likely Neutral,Likely Neutral,4,ENST00000219476,NM_000548.3,No,Yes ATR,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000350721,NM_001184.3,No,Yes KMT2D,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000301067,NM_003482.3,No,Yes KMT2D,R5432W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000301067,NM_003482.3,No,Yes KMT2D,C1471Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000301067,NM_003482.3,No,Yes KMT2D,Y5426A,Inconclusive,Inconclusive,4,ENST00000301067,NM_003482.3,No,Yes KMT2D,C1430R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000301067,NM_003482.3,No,Yes KMT2D,Y5512A,Inconclusive,Inconclusive,4,ENST00000301067,NM_003482.3,No,Yes MBD4,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000249910,NM_003925,No,Yes HTATIP2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000421577,NM_001098521,No,Yes RASA1,L481F,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274376,NM_002890.2,No,Yes RASA1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274376,NM_002890.2,No,Yes RASA1,Y472H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000274376,NM_002890.2,No,Yes MEN1,M327I,Resistance,Inconclusive,4,ENST00000312049,NM_130799.2,No,Yes MEN1,T349M,Resistance,Inconclusive,4,ENST00000312049,NM_130799.2,No,Yes MEN1,G331D,Resistance,Inconclusive,4,ENST00000312049,NM_130799.2,No,Yes MEN1,G331R,Resistance,Inconclusive,4,ENST00000312049,NM_130799.2,No,Yes MEN1,M327V,Resistance,Inconclusive,4,ENST00000312049,NM_130799.2,No,Yes MEN1,S253L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000312049,NM_130799.2,No,Yes MEN1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000312049,NM_130799.2,No,Yes PAX5,V26G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358127,NM_016734.2,No,Yes PAX5,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000358127,NM_016734.2,No,Yes EZH1,Q571R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000428826,NM_001991.3,Yes,No FANCL,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000233741,NM_018062.3,No,Yes TBX3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000257566,NM_016569.3,No,Yes BCL11B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000357195,NM_138576.3,No,Yes BCL11B,N441K,Likely Oncogenic,Loss-of-function,4,ENST00000357195,NM_138576.3,No,Yes B2M,M1R,Likely Oncogenic,Loss-of-function,4,ENST00000558401,NM_004048.2,No,Yes B2M,M1T,Likely Oncogenic,Loss-of-function,4,ENST00000558401,NM_004048.2,No,Yes B2M,M1K,Likely Oncogenic,Loss-of-function,4,ENST00000558401,NM_004048.2,No,Yes B2M,M1I,Likely Oncogenic,Loss-of-function,4,ENST00000558401,NM_004048.2,No,Yes B2M,M1V,Likely Oncogenic,Loss-of-function,4,ENST00000558401,NM_004048.2,No,Yes B2M,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000558401,NM_004048.2,No,Yes SMAD3,P336S,Likely Oncogenic,Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,R292A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,Y298A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,R373Q,Likely Oncogenic,Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,D408E,Likely Oncogenic,Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,D258N,Likely Oncogenic,Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,V277D,Likely Oncogenic,Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,Y226A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,K341A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,Y238A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,V356R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,R268C,Likely Oncogenic,Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,R243A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,W406A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,R373H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,E239A,Likely Oncogenic,Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,R268A,Likely Oncogenic,Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,D408Y,Likely Oncogenic,Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,Y384A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,D408H,Likely Oncogenic,Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,Y237A,Likely Neutral,Neutral,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,S425C,Likely Oncogenic,Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,R287A,Likely Oncogenic,Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes SMAD3,Y297A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000327367,NM_005902.3,No,Yes JARID2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000341776,NM_004973.3,Yes,Yes CCNQ,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000576892,NM_152274.4,No,Yes FOXP1,R514C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000318789,NM_001244814.1,Yes,Yes FOXP1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000318789,NM_001244814.1,Yes,Yes AKT2,I289M,Likely Oncogenic,Likely Gain-of-function,4,ENST00000392038,NM_001626.4,Yes,No AKT2,E17K,Oncogenic,Gain-of-function,4,ENST00000392038,NM_001626.4,Yes,No AKT2,R170W,Likely Oncogenic,Likely Gain-of-function,4,ENST00000392038,NM_001626.4,Yes,No AKT2,G161V,Inconclusive,Inconclusive,4,ENST00000392038,NM_001626.4,Yes,No AKT2,D324N,Inconclusive,Inconclusive,4,ENST00000392038,NM_001626.4,Yes,No AKT2,H355Y,Likely Oncogenic,Likely Gain-of-function,4,ENST00000392038,NM_001626.4,Yes,No AKT2,R368C,Likely Oncogenic,Likely Gain-of-function,4,ENST00000392038,NM_001626.4,Yes,No AKT2,K181M,Inconclusive,Inconclusive,4,ENST00000392038,NM_001626.4,Yes,No IRF1,M8L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000245414,NM_002198.2,No,Yes IRF1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000245414,NM_002198.2,No,Yes CSF1R,E633K,Likely Neutral,Likely Loss-of-function,4,ENST00000286301,NM_005211.3,No,No CSF1R,I794T,Likely Neutral,Likely Loss-of-function,4,ENST00000286301,NM_005211.3,No,No CSF1R,W450_E456del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000286301,NM_005211.3,No,No CSF1R,P386L,Likely Oncogenic,Likely Gain-of-function,4,ENST00000286301,NM_005211.3,No,No CSF1R,Y561_I564del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000286301,NM_005211.3,No,No CSF1R,M875T,Likely Neutral,Likely Loss-of-function,4,ENST00000286301,NM_005211.3,No,No CSF1R,Y546_K551del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000286301,NM_005211.3,No,No CSF1R,G585_K619delinsA,Inconclusive,Inconclusive,4,ENST00000286301,NM_005211.3,No,No CDK12,K975E,Inconclusive,Inconclusive,4,ENST00000447079,NM_016507.2,No,Yes CDK12,Y901C,Likely Oncogenic,Loss-of-function,4,ENST00000447079,NM_016507.2,No,Yes CDK12,W719*,Likely Oncogenic,Loss-of-function,4,ENST00000447079,NM_016507.2,No,Yes CDK12,E928_L929insYTKI,Likely Oncogenic,Likely Loss-of-function,4,ENST00000447079,NM_016507.2,No,Yes CDK12,K764R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000447079,NM_016507.2,No,Yes CDK12,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000447079,NM_016507.2,No,Yes CDK12,R882L,Likely Oncogenic,Loss-of-function,4,ENST00000447079,NM_016507.2,No,Yes CDK12,D877N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000447079,NM_016507.2,No,Yes CDK12,G909R,Likely Oncogenic,Loss-of-function,4,ENST00000447079,NM_016507.2,No,Yes CDK12,L996F,Likely Oncogenic,Loss-of-function,4,ENST00000447079,NM_016507.2,No,Yes RAD51,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000267868,NM_002875.4,No,Yes MITF,E318K,Likely Oncogenic,Likely Gain-of-function,4,ENST00000394351,NM_000248.3,Yes,Yes MITF,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000394351,NM_000248.3,Yes,Yes CRBN,R419*,Likely Oncogenic,Likely Loss-of-function,4,ENST00000231948,NM_016302.3,No,Yes CRBN,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000231948,NM_016302.3,No,Yes TSC1,L191H,Likely Oncogenic,Loss-of-function,4,ENST00000298552,NM_000368.4,No,Yes TSC1,V128del,Likely Oncogenic,Loss-of-function,4,ENST00000298552,NM_000368.4,No,Yes TSC1,H68R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000298552,NM_000368.4,No,Yes TSC1,V220F,Inconclusive,Inconclusive,4,ENST00000298552,NM_000368.4,No,Yes TSC1,F158C,Likely Oncogenic,Loss-of-function,4,ENST00000298552,NM_000368.4,No,Yes TSC1,R1097H,Likely Neutral,Neutral,4,ENST00000298552,NM_000368.4,No,Yes TSC1,L117P,Likely Oncogenic,Loss-of-function,4,ENST00000298552,NM_000368.4,No,Yes TSC1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000298552,NM_000368.4,No,Yes TSC1,T417I,Likely Neutral,Neutral,4,ENST00000298552,NM_000368.4,No,Yes TSC1,H206D,Likely Oncogenic,Loss-of-function,4,ENST00000298552,NM_000368.4,No,Yes TSC1,R246K,Likely Neutral,Neutral,4,ENST00000298552,NM_000368.4,No,Yes TSC1,H105R,Likely Oncogenic,Loss-of-function,4,ENST00000298552,NM_000368.4,No,Yes TSC1,G305W,Likely Neutral,Neutral,4,ENST00000298552,NM_000368.4,No,Yes TSC1,G1035S,Likely Neutral,Neutral,4,ENST00000298552,NM_000368.4,No,Yes TSC1,G305R,Likely Neutral,Neutral,4,ENST00000298552,NM_000368.4,No,Yes TSC1,R509Q,Likely Neutral,Neutral,4,ENST00000298552,NM_000368.4,No,Yes TSC1,L180P,Likely Oncogenic,Loss-of-function,4,ENST00000298552,NM_000368.4,No,Yes TSC1,F216A,Inconclusive,Inconclusive,4,ENST00000298552,NM_000368.4,No,Yes TSC1,N198_F199delinsI,Likely Oncogenic,Loss-of-function,4,ENST00000298552,NM_000368.4,No,Yes TSC1,S35Q,Likely Oncogenic,Loss-of-function,4,ENST00000298552,NM_000368.4,No,Yes TSC1,K82T,Likely Neutral,Likely Neutral,4,ENST00000298552,NM_000368.4,No,Yes TSC1,M224R,Oncogenic,Loss-of-function,4,ENST00000298552,NM_000368.4,No,Yes BIRC3,R448Q,Likely Neutral,Likely Neutral,4,ENST00000263464,NM_182962.2,No,No BIRC3,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263464,NM_182962.2,No,No BIRC3,S7I,Likely Neutral,Likely Neutral,4,ENST00000263464,NM_182962.2,No,No BIRC3,G297D,Likely Neutral,Likely Neutral,4,ENST00000263464,NM_182962.2,No,No BIRC3,R172I,Likely Neutral,Likely Neutral,4,ENST00000263464,NM_182962.2,No,No BIRC3,S278R,Likely Neutral,Likely Neutral,4,ENST00000263464,NM_182962.2,No,No BIRC3,G472R,Likely Neutral,Likely Neutral,4,ENST00000263464,NM_182962.2,No,No BIRC3,T488M,Likely Neutral,Likely Neutral,4,ENST00000263464,NM_182962.2,No,No BIRC3,T536R,Likely Neutral,Likely Neutral,4,ENST00000263464,NM_182962.2,No,No BIRC3,C319Y,Likely Neutral,Likely Neutral,4,ENST00000263464,NM_182962.2,No,No BIRC3,S248C,Likely Neutral,Likely Neutral,4,ENST00000263464,NM_182962.2,No,No BIRC3,H574A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000263464,NM_182962.2,No,No RAD50,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000265335,NM_005732.3,No,Yes RAD50,D69Y,Likely Oncogenic,Likely Loss-of-function,4,ENST00000265335,NM_005732.3,No,Yes RAD50,D69N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000265335,NM_005732.3,No,Yes RAD50,L234fs,Likely Oncogenic,Likely Loss-of-function,4,ENST00000265335,NM_005732.3,No,Yes RAD50,L1237F,Likely Oncogenic,Loss-of-function,4,ENST00000265335,NM_005732.3,No,Yes FAT1,P4309A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000441802,NM_005245.3,No,Yes FAT1,T4511I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000441802,NM_005245.3,No,Yes FAT1,A4419S,Likely Oncogenic,Likely Loss-of-function,4,ENST00000441802,NM_005245.3,No,Yes FAT1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000441802,NM_005245.3,No,Yes EZH2,Y731D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320356,NM_004456.4,Yes,Yes EZH2,Y646S,Oncogenic,Likely Gain-of-function,4,ENST00000320356,NM_004456.4,Yes,Yes EZH2,K665R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320356,NM_004456.4,Yes,Yes EZH2,A682G,Likely Oncogenic,Likely Gain-of-function,4,ENST00000320356,NM_004456.4,Yes,Yes EZH2,K515R,Likely Neutral,Likely Neutral,4,ENST00000320356,NM_004456.4,Yes,Yes EZH2,Y646H,Oncogenic,Likely Gain-of-function,4,ENST00000320356,NM_004456.4,Yes,Yes EZH2,R690C,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320356,NM_004456.4,Yes,Yes EZH2,C576W,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320356,NM_004456.4,Yes,Yes EZH2,K665E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320356,NM_004456.4,Yes,Yes EZH2,Y646N,Likely Oncogenic,Likely Gain-of-function,4,ENST00000320356,NM_004456.4,Yes,Yes EZH2,Y646C,Oncogenic,Likely Gain-of-function,4,ENST00000320356,NM_004456.4,Yes,Yes EZH2,A692V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000320356,NM_004456.4,Yes,Yes EZH2,Y646F,Likely Oncogenic,Likely Gain-of-function,4,ENST00000320356,NM_004456.4,Yes,Yes EZH2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000320356,NM_004456.4,Yes,Yes HSD17B2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000199936,NM_002153,No,Yes HSD17B2,G160R,Likely Neutral,Likely Neutral,4,ENST00000199936,NM_002153,No,Yes HSD17B2,A111D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000199936,NM_002153,No,Yes AKT3,E17K,Oncogenic,Gain-of-function,4,ENST00000263826,NM_005465.4,Yes,No TERT,Y846C,Likely Neutral,Likely Loss-of-function,4,ENST00000310581,NM_198253.2,Yes,No TERT,L392Vfs*146,Inconclusive,Inconclusive,4,ENST00000310581,NM_198253.2,Yes,No TERT,H412Y,Likely Neutral,Likely Loss-of-function,4,ENST00000310581,NM_198253.2,Yes,No TERT,R1084*,Inconclusive,Inconclusive,4,ENST00000310581,NM_198253.2,Yes,No TERT,H876Q,Likely Neutral,Likely Loss-of-function,4,ENST00000310581,NM_198253.2,Yes,No TERT,P308Hfs*43,Inconclusive,Inconclusive,4,ENST00000310581,NM_198253.2,Yes,No TERT,Promoter Mutation,Likely Oncogenic,Likely Gain-of-function,4,ENST00000310581,NM_198253.2,Yes,No TERT,P704S,Likely Neutral,Likely Loss-of-function,4,ENST00000310581,NM_198253.2,Yes,No HDAC1,K432R,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373548,NM_004964.2,Yes,No HDAC1,H141A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000373548,NM_004964.2,Yes,No ARAF,Q347_A348del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000377045,NM_001654.4,Yes,No ARAF,G387N,Resistance,Inconclusive,4,ENST00000377045,NM_001654.4,Yes,No ARAF,P216A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000377045,NM_001654.4,Yes,No ARAF,S214A,Likely Oncogenic,Likely Gain-of-function,4,ENST00000377045,NM_001654.4,Yes,No ARAF,G387R,Resistance,Inconclusive,4,ENST00000377045,NM_001654.4,Yes,No ARAF,S214F,Oncogenic,Gain-of-function,4,ENST00000377045,NM_001654.4,Yes,No ARAF,S214T,Likely Oncogenic,Gain-of-function,4,ENST00000377045,NM_001654.4,Yes,No ARAF,G322S,Likely Oncogenic,Likely Gain-of-function,4,ENST00000377045,NM_001654.4,Yes,No ARAF,N217I,Oncogenic,Gain-of-function,4,ENST00000377045,NM_001654.4,Yes,No ARAF,F351L,Oncogenic,Gain-of-function,4,ENST00000377045,NM_001654.4,Yes,No ARAF,G387D,Resistance,Inconclusive,4,ENST00000377045,NM_001654.4,Yes,No ARAF,P462L,Resistance,Inconclusive,4,ENST00000377045,NM_001654.4,Yes,No ARAF,G377R,Resistance,Inconclusive,4,ENST00000377045,NM_001654.4,Yes,No ARAF,S214C,Oncogenic,Gain-of-function,4,ENST00000377045,NM_001654.4,Yes,No RTEL1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000360203,NM_001283009.1,No,Yes RTEL1,M492I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000360203,NM_001283009.1,No,Yes USP8,S718P,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307179,NM_001128610.2,Yes,No USP8,S718del,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307179,NM_001128610.2,Yes,No USP8,P720R,Likely Oncogenic,Likely Gain-of-function,4,ENST00000307179,NM_001128610.2,Yes,No USP8,C748A,Likely Neutral,Likely Loss-of-function,4,ENST00000307179,NM_001128610.2,Yes,No SMAD2,S276L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,D450H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,N387P,Inconclusive,Inconclusive,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,P305L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,R428A,Inconclusive,Inconclusive,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,S465A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,S467P,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,Y426A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,K375A,Inconclusive,Inconclusive,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,R321Q,Likely Oncogenic,Loss-of-function,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,D300N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,D450E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,Y406H,Inconclusive,Inconclusive,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,F346V,Likely Neutral,Likely Neutral,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,S467A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,T413N,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,K420A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,D300H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,R310H,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,V319D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,W368H,Likely Neutral,Likely Neutral,4,ENST00000262160,NM_001003652.3,No,Yes SMAD2,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000262160,NM_001003652.3,No,Yes ANKRD11,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000301030,NM_013275.5,No,Yes DICER1,E1813A,Likely Oncogenic,Loss-of-function,4,ENST00000393063,NM_177438.2,No,Yes DICER1,S1344L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000393063,NM_177438.2,No,Yes DICER1,D1810A,Likely Oncogenic,Loss-of-function,4,ENST00000393063,NM_177438.2,No,Yes DICER1,D1709N,Oncogenic,Loss-of-function,4,ENST00000393063,NM_177438.2,No,Yes DICER1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,4,ENST00000393063,NM_177438.2,No,Yes DICER1,E1705K,Likely Oncogenic,Loss-of-function,4,ENST00000393063,NM_177438.2,No,Yes DICER1,G1809R,Oncogenic,Loss-of-function,4,ENST00000393063,NM_177438.2,No,Yes DICER1,E1705A,Likely Oncogenic,Loss-of-function,4,ENST00000393063,NM_177438.2,No,Yes DICER1,D1709A,Likely Oncogenic,Likely Loss-of-function,4,ENST00000393063,NM_177438.2,No,Yes DICER1,D1709E,Likely Oncogenic,Likely Loss-of-function,4,ENST00000393063,NM_177438.2,No,Yes DICER1,E1813G,Likely Oncogenic,Likely Loss-of-function,4,ENST00000393063,NM_177438.2,No,Yes DICER1,R944Q,Likely Neutral,Likely Neutral,4,ENST00000393063,NM_177438.2,No,Yes DICER1,G1809K,Likely Oncogenic,Loss-of-function,4,ENST00000393063,NM_177438.2,No,Yes ACTG1,G310A,Inconclusive,Inconclusive,1,ENST00000331925,NM_001199954.1,No,Yes ATM,L590R,Likely Oncogenic,Likely Loss-of-function,3,ENST00000278616,NM_000051.3,No,Yes ATM,R2032K,Inconclusive,Inconclusive,6,ENST00000278616,NM_000051.3,No,Yes ATP6AP1,R71H,Likely Oncogenic,Loss-of-function,1,ENST00000369762,NM_001183.5,No,No ATP6AP1,L98S,Likely Oncogenic,Loss-of-function,1,ENST00000369762,NM_001183.5,No,No BAP1,V99M,Inconclusive,Inconclusive,2,ENST00000460680,NM_004656.3,No,Yes BRAF,V600D_K601insFGLAT,Oncogenic,Gain-of-function,1,ENST00000288602,NM_004333.4,Yes,No BRAF,V600_K601delinsE,Oncogenic,Gain-of-function,2,ENST00000288602,NM_004333.4,Yes,No BRAF,T599_V600insEAT,Likely Oncogenic,Likely Gain-of-function,1,ENST00000288602,NM_004333.4,Yes,No BRAF,T599_V600insETT,Likely Oncogenic,Likely Gain-of-function,1,ENST00000288602,NM_004333.4,Yes,No BRAF,K601_S602delinsNT,Likely Oncogenic,Likely Gain-of-function,2,ENST00000288602,NM_004333.4,Yes,No BRAF,K601_W604del,Inconclusive,Inconclusive,1,ENST00000288602,NM_004333.4,Yes,No BRCA1,E23fs,Oncogenic,Loss-of-function,7,ENST00000357654,NM_007294.3,No,Yes BRCA1,T47D,Likely Neutral,Likely Neutral,1,ENST00000357654,NM_007294.3,No,Yes BRCA1,E60L,Inconclusive,Inconclusive,2,ENST00000357654,NM_007294.3,No,Yes BRCA2,N2829R,Likely Oncogenic,Likely Loss-of-function,1,ENST00000380152,NM_000059.3,No,Yes BRCA2,A2466V,Likely Neutral,Likely Neutral,1,ENST00000380152,NM_000059.3,No,Yes BRCA2,V2678G,Likely Neutral,Likely Neutral,1,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2901D,Likely Neutral,Likely Neutral,1,ENST00000380152,NM_000059.3,No,Yes BRCA2,P3065S,Likely Neutral,Likely Neutral,1,ENST00000380152,NM_000059.3,No,Yes BRCA2,S1670A,Inconclusive,Inconclusive,1,ENST00000380152,NM_000059.3,No,Yes BRCA2,R2304C,Inconclusive,Inconclusive,1,ENST00000380152,NM_000059.3,No,Yes CALR,C-terminal truncating mutation,Likely Oncogenic,Likely Gain-of-function,3,ENST00000316448,NM_004343.3,Yes,No CALR,Exon 9 indel,Likely Neutral,Likely Neutral,3,ENST00000316448,NM_004343.3,Yes,No CALR,309_417ins,Likely Neutral,Likely Neutral,3,ENST00000316448,NM_004343.3,Yes,No CARD11,G116S,Likely Oncogenic,Likely Gain-of-function,1,ENST00000396946,NM_032415.4,Yes,No CARD11,F123I,Likely Oncogenic,Likely Gain-of-function,2,ENST00000396946,NM_032415.4,Yes,No CARD11,E127G,Likely Oncogenic,Likely Gain-of-function,1,ENST00000396946,NM_032415.4,Yes,No CARD11,L225LI,Likely Oncogenic,Gain-of-function,3,ENST00000396946,NM_032415.4,Yes,No CARM1,S217E,Inconclusive,Likely Loss-of-function,1,ENST00000327064,NM_199141.1,No,No CARM1,S217T,Inconclusive,Likely Loss-of-function,1,ENST00000327064,NM_199141.1,No,No CARM1,S217A,Inconclusive,Likely Loss-of-function,1,ENST00000327064,NM_199141.1,No,No CARM1,S217C,Inconclusive,Likely Loss-of-function,1,ENST00000327064,NM_199141.1,No,No CASP8,CASP8L,Likely Oncogenic,Loss-of-function,4,ENST00000358485,NM_001080125.1,No,Yes CASP8,C248T,Likely Oncogenic,Likely Loss-of-function,1,ENST00000358485,NM_001080125.1,No,Yes CASP8,G325A,Likely Oncogenic,Likely Gain-of-function,1,ENST00000358485,NM_001080125.1,No,Yes CCND3,T286A,Likely Oncogenic,Gain-of-function,1,ENST00000372991,NM_001760.3,Yes,No CD79B,Y196H,Oncogenic,Gain-of-function,4,ENST00000392795,NM_001039933.1,Yes,No CD79B,Y196F,Oncogenic,Gain-of-function,3,ENST00000392795,NM_001039933.1,Yes,No CD79B,Y196C,Oncogenic,Gain-of-function,3,ENST00000392795,NM_001039933.1,Yes,No CD79B,E197G,Oncogenic,Gain-of-function,3,ENST00000392795,NM_001039933.1,Yes,No CDK12,K765R,Likely Oncogenic,Likely Loss-of-function,2,ENST00000447079,NM_016507.2,No,Yes CDKN2A,P73L,Oncogenic,Loss-of-function,1,ENST00000304494,NM_000077.4,No,Yes CDKN2A,R79P,Oncogenic,Loss-of-function,1,ENST00000304494,NM_000077.4,No,Yes CDKN2A,L97R,Oncogenic,Loss-of-function,2,ENST00000304494,NM_000077.4,No,Yes CDKN2A,V118D,Oncogenic,Loss-of-function,1,ENST00000304494,NM_000077.4,No,Yes CDKN2A,V126D,Oncogenic,Loss-of-function,1,ENST00000304494,NM_000077.4,No,Yes CDKN2A,R80L,Likely Oncogenic,Likely Loss-of-function,1,ENST00000304494,NM_000077.4,No,Yes CDKN2A,G93W,Likely Oncogenic,Loss-of-function,1,ENST00000304494,NM_000077.4,No,Yes CIC,Q274R,Likely Oncogenic,Likely Loss-of-function,1,ENST00000575354,NM_015125.3,No,Yes CIITA,R35*,Likely Oncogenic,Loss-of-function,1,ENST00000324288,NM_001286402,No,Yes CSF1R,E631K,Likely Neutral,Likely Loss-of-function,1,ENST00000286301,NM_005211.3,No,No CSF1R,I792T,Likely Neutral,Likely Loss-of-function,1,ENST00000286301,NM_005211.3,No,No CSF1R,M873T,Likely Neutral,Likely Loss-of-function,1,ENST00000286301,NM_005211.3,No,No CXORF67,T73S,Likely Oncogenic,Likely Gain-of-function,1,ENST00000342995,NM_203407.2,Yes,No CXORF67,I88F,Likely Oncogenic,Likely Gain-of-function,1,ENST00000342995,NM_203407.2,Yes,No CXORF67,Y184C,Likely Oncogenic,Likely Gain-of-function,1,ENST00000342995,NM_203407.2,Yes,No EGFR,Exon 19 insertion,Oncogenic,Gain-of-function,8,ENST00000275493,NM_005228.3,Yes,No EGFR,Exon 19 deletion,Oncogenic,Gain-of-function,13,ENST00000275493,NM_005228.3,Yes,No EGFR,E746_E749del,Oncogenic,Gain-of-function,4,ENST00000275493,NM_005228.3,Yes,No EGFR,L747_P753delinsN,Likely Oncogenic,Gain-of-function,,,,, EGFR,Exon 20 insertion,Oncogenic,Gain-of-function,8,ENST00000275493,NM_005228.3,Yes,No EGFR,A775_G776insYVMA,Oncogenic,Gain-of-function,FDA,ENST00000275493,NM_005228.3,Yes,No EGFR,N771_P772insVDN,Oncogenic,Gain-of-function,,ENST00000275493,NM_005228.3,Yes,No EGFR,L841V,Oncogenic,Gain-of-function,1,ENST00000275493,NM_005228.3,Yes,No EGFR,A743T,Likely Neutral,Neutral,1,ENST00000275493,NM_005228.3,Yes,No EGFR,S752Kfs*12,Likely Oncogenic,Likely Gain-of-function,1,ENST00000275493,NM_005228.3,Yes,No EPAS1,533_534del,Likely Oncogenic,Likely Gain-of-function,2,ENST00000263734,NM_001430.4,No,No EPAS1,534_536del,Likely Oncogenic,Likely Gain-of-function,2,ENST00000263734,NM_001430.4,No,No ERBB2,Exon 20 deletions,Likely Oncogenic,Likely Gain-of-function,8,ENST00000269571,NM_004448.2,Yes,No ERBB2,Exon 20 insertion,Likely Oncogenic,Likely Gain-of-function,8,ENST00000269571,NM_004448.2,Yes,No ERBB3,V855A,Likely Oncogenic,Likely Gain-of-function,,ENST00000267101,NM_001982.3,Yes,No ERBB4,G1109C,Likely Oncogenic,Gain-of-function,,ENST00000342788,NM_005235.2,Yes,No ERCC2,Q785E,Likely Neutral,Likely Neutral,1,ENST00000391945,NM_000400.3,No,Yes ETV6,385_418del,Likely Oncogenic,Loss-of-function,1,ENST00000396373,NM_001987.4,No,Yes EZH2,A687V,Likely Oncogenic,Likely Gain-of-function,3,ENST00000320356,NM_004456.4,Yes,Yes FANCD2,L310S,Likely Oncogenic,Likely Loss-of-function,1,ENST00000383807,NM_001018115.1,No,Yes FBXW7,R482Q,Oncogenic,Loss-of-function,1,ENST00000281708,NM_033632.3,No,Yes FBXW7,E192A,Likely Oncogenic,Likely Loss-of-function,,ENST00000281708,NM_033632.3,No,Yes FGFR1,E664K,Likely Neutral,Likely Loss-of-function,1,ENST00000425967,NM_001174067.1,Yes,No FGFR2,K525E,Likely Oncogenic,Likely Gain-of-function,1,ENST00000358487,NM_000141.4,Yes,No FGFR2,T730S,Likely Neutral,Likely Neutral,1,ENST00000358487,NM_000141.4,Yes,No FGFR2,V755I,Likely Neutral,Likely Neutral,1,ENST00000358487,NM_000141.4,Yes,No FLT3,E604_Y958ins,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,E604_Y958mis,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,Tyrosine kinase domain mutation,Likely Oncogenic,Likely Gain-of-function,4,ENST00000241453,NM_004119.2,Yes,No FLT3,D835G,Likely Oncogenic,Likely Gain-of-function,,ENST00000241453,NM_004119.2,Yes,No FOXA1,R266L,Likely Oncogenic,Likely Gain-of-function,1,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,D266N,Likely Oncogenic,Likely Gain-of-function,1,ENST00000250448,NM_004496.3,Yes,Yes FOXA1,G275*,Likely Oncogenic,Likely Gain-of-function,1,ENST00000250448,NM_004496.3,Yes,Yes GATA3,R177Pfs*126,Likely Oncogenic,Loss-of-function,1,ENST00000346208,NM_002051.2,Yes,Yes GNAS,R844H,Oncogenic,Gain-of-function,2,ENST00000371085,NM_000516.4,Yes,No GTF2I,L383H,Likely Oncogenic,Gain-of-function,1,ENST00000324896,NM_032999.3,Yes,No GTF2I,L404H,Likely Oncogenic,Gain-of-function,1,ENST00000324896,NM_032999.3,Yes,No HIST1H1B,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,3,ENST00000331442,NM_005322.2,No,Yes HIST1H1D,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,3,ENST00000244534,NM_005320.2,No,Yes HRAS,G13V,Likely Oncogenic,Likely Gain-of-function,4,ENST00000311189,NM_001130442.1,Yes,No HRAS,G13C,Likely Oncogenic,Likely Gain-of-function,5,ENST00000311189,NM_001130442.1,Yes,No HRAS,G13R,Likely Oncogenic,Likely Gain-of-function,2,ENST00000311189,NM_001130442.1,Yes,No IGF1R,G119T,Likely Oncogenic,Loss-of-function,1,ENST00000268035,NM_000875.3,Yes,No IGF1R,A1374V,Likely Oncogenic,Likely Gain-of-function,1,ENST00000268035,NM_000875.3,Yes,No IGF1R,G1125A,Likely Neutral,Likely Loss-of-function,1,ENST00000268035,NM_000875.3,Yes,No JAK1,G871E,Likely Oncogenic,Likely Loss-of-function,1,ENST00000342505,NM_002227.2,Yes,Yes JAK1,G1079D,Likely Oncogenic,Gain-of-function,1,ENST00000342505,NM_002227.2,Yes,Yes JAK2,R277K,Oncogenic,Inconclusive,1,ENST00000381652,NM_004972.3,Yes,No JAK2,Exon 12 missense mutation,Likely Oncogenic,Gain-of-function,1,ENST00000381652,NM_004972.3,Yes,No JAK2,Exon 12 insertion,Likely Oncogenic,Gain-of-function,1,ENST00000381652,NM_004972.3,Yes,No JAK2,Exon 12 deletion,Likely Oncogenic,Gain-of-function,1,ENST00000381652,NM_004972.3,Yes,No JAK3,A572V,Oncogenic,Gain-of-function,,ENST00000458235,NM_000215.3,Yes,No KBTBD4,R313delinsPRR,Inconclusive,Inconclusive,1,ENST00000395288,NM_016506.5,No,No KDM5C,M1_E165DEL,Likely Oncogenic,Loss-of-function,1,ENST00000375401,NM_004187.3,No,Yes KDR,R961W,Likely Oncogenic,Likely Gain-of-function,,ENST00000263923,NM_002253.2,Yes,No KIT,Exon 11 deletion,Oncogenic,Gain-of-function,8,ENST00000288135,NM_000222.2,Yes,No KIT,D572_P573dup,Likely Oncogenic,Likely Gain-of-function,1,ENST00000288135,NM_000222.2,Yes,No KIT,Q575_L576dup,Likely Oncogenic,Likely Gain-of-function,1,ENST00000288135,NM_000222.2,Yes,No KIT,D579_H580insFNPTQLPYD,Likely Oncogenic,Likely Gain-of-function,1,ENST00000288135,NM_000222.2,Yes,No KIT,D579_H580insLPCD,Likely Oncogenic,Likely Gain-of-function,1,ENST00000288135,NM_000222.2,Yes,No KIT,I669_T670delinsMI,Likely Oncogenic,Likely Gain-of-function,1,ENST00000288135,NM_000222.2,Yes,No KIT,Y823N,Likely Oncogenic,Likely Gain-of-function,1,ENST00000288135,NM_000222.2,Yes,No KRAS,G12N,Oncogenic,Gain-of-function,FDA approved - On Companion Diagnostic,ENST00000311936,NM_004985,Yes,No LRP5,W781A,Likely Oncogenic,Likely Gain-of-function,1,ENST00000294304,NM_001291902.1,Yes,Yes LRP6,R379G,Likely Neutral,Likely Loss-of-function,1,ENST00000261349,NM_002336.2,Yes,No LZTR1,G284C,Oncogenic,Likely Loss-of-function,1,ENST00000215739,NM_006767.3,No,Yes MAP2K1,L105_A106del,Likely Oncogenic,Likely Gain-of-function,1,ENST00000307102,NM_002755.3,Yes,No MAP2K1,L105_I107delinsL,Likely Oncogenic,Likely Gain-of-function,1,ENST00000307102,NM_002755.3,Yes,No MAP2K1,M164E,Likely Neutral,Likely Neutral,1,ENST00000307102,NM_002755.3,Yes,No MAP2K1,G179C,Likely Neutral,Likely Neutral,1,ENST00000307102,NM_002755.3,Yes,No MAP2K1,D190Y,Likely Neutral,Likely Neutral,1,ENST00000307102,NM_002755.3,Yes,No MAP3K1,T1481fs,Likely Oncogenic,Likely Loss-of-function,1,ENST00000399503,NM_005921.1,No,Yes MAPK1,E69R,Inconclusive,Inconclusive,1,ENST00000215832,NM_002745.4,Yes,No MED12,Exon 1 mutation,Oncogenic,Likely Loss-of-function,1,ENST00000374080,NM_005120.2,Yes,Yes MED12,Exon 2 mutation,Oncogenic,Likely Loss-of-function,6,ENST00000374080,NM_005120.2,Yes,Yes MET,Exon 14 splice mutation,Oncogenic,Gain-of-function,8,ENST00000397752,NM_000245.2,Yes,No MET,Exon 14 deletion,Oncogenic,Gain-of-function,8,ENST00000397752,NM_000245.2,Yes,No MET,R988C,Likely Oncogenic,Likely Gain-of-function,1,ENST00000397752,NM_000245.2,Yes,No MET,F1080S,Likely Oncogenic,Likely Gain-of-function,1,ENST00000397752,NM_000245.2,Yes,No MLH1,N306K,Likely Oncogenic,Likely Loss-of-function,2,ENST00000231790,NM_000249.3,No,Yes MLH1,K618del,Likely Oncogenic,Likely Loss-of-function,6,ENST00000231790,NM_000249.3,No,Yes MLH1,A441T,Inconclusive,Inconclusive,1,ENST00000231790,NM_000249.3,No,Yes MPL,Exon 10 mutation,Likely Oncogenic,Likely Gain-of-function,12,ENST00000372470,NM_005373.2,Yes,No MSH2,I624S,Likely Oncogenic,Likely Loss-of-function,1,ENST00000233146,NM_000251.2,No,Yes MUTYH,R109W,Likely Oncogenic,Likely Loss-of-function,5,ENST00000372115,NM_001048171.1,No,Yes MUTYH,Y179C,Likely Oncogenic,Likely Loss-of-function,1,ENST00000372115,NM_001048171.1,No,Yes MUTYH,R182C,Likely Oncogenic,Likely Loss-of-function,7,ENST00000372115,NM_001048171.1,No,Yes MUTYH,R245C,Likely Oncogenic,Likely Loss-of-function,1,ENST00000372115,NM_001048171.1,No,Yes MUTYH,R274Q,Likely Oncogenic,Likely Loss-of-function,7,ENST00000372115,NM_001048171.1,No,Yes MUTYH,G396D,Likely Oncogenic,Likely Loss-of-function,4,ENST00000372115,NM_001048171.1,No,Yes MUTYH,P405L,Likely Oncogenic,Likely Loss-of-function,7,ENST00000372115,NM_001048171.1,No,Yes MUTYH,E480del,Likely Oncogenic,Likely Loss-of-function,2,ENST00000372115,NM_001048171.1,No,Yes NFE2L2,Exon 2 deletion,Likely Oncogenic,Gain-of-function,1,ENST00000397062,NM_006164.4,Yes,No NFE2L2,Exon 2 and 3 deletion,Likely Oncogenic,Gain-of-function,1,ENST00000397062,NM_006164.4,Yes,No NKX2-1,A339V,Likely Oncogenic,Likely Gain-of-function,1,ENST00000354822,NM_001079668.2,Yes,No NOTCH1,Truncating Mutations,Likely Oncogenic,Likely Loss-of-function,5,ENST00000277541,NM_017617.3,Yes,Yes NRAS,G12N,Oncogenic,Gain-of-function,FDA approved - On Companion Diagnostic,ENST00000369535,NM_002524.4,Yes,No NRAS,K117N,Oncogenic,Gain-of-function,FDA approved - On Companion Diagnostic,ENST00000369535,NM_002524.4,Yes,No NTRK1,V573M,Likely Oncogenic,Likely Gain-of-function,,ENST00000524377,NM_002529.3,Yes,No PBRM1,N1333Gfs*,Oncogenic,Loss-of-function,1,ENST00000394830,NM_018313.4,No,Yes PIK3CA,G106_R108delGNR,Likely Oncogenic,Likely Gain-of-function,1,ENST00000263967,NM_006218.2,Yes,No PIK3CB,F930S,Likely Oncogenic,Likely Gain-of-function,1,ENST00000289153,NM_006219.2,Yes,No PIK3CB,K944N,Likely Oncogenic,Likely Gain-of-function,1,ENST00000289153,NM_006219.2,Yes,No PIK3CB,V955I,Likely Oncogenic,Likely Gain-of-function,1,ENST00000289153,NM_006219.2,Yes,No PIK3CB,V955G,Likely Oncogenic,Likely Gain-of-function,1,ENST00000289153,NM_006219.2,Yes,No PIK3CB,K966E,Likely Oncogenic,Likely Gain-of-function,1,ENST00000289153,NM_006219.2,Yes,No PIK3CA,Exon 20 mutation,Inconclusive,Inconclusive,5,ENST00000263967,NM_006218.2,Yes,No PMS2,E541K,Likely Neutral,Likely Neutral,2,ENST00000265849,NM_000535.5,No,Yes POLE,S279Y,Likely Oncogenic,Likely Loss-of-function,2,ENST00000320574,NM_006231.2,No,Yes PPP2R2A,G247T,Likely Oncogenic,Likely Loss-of-function,1,ENST00000380737,NM_002717.3,No,Yes PRDM1,P48R,Likely Oncogenic,Loss-of-function,1,ENST00000369096,NM_001198.3,No,Yes PRDM1,P48T,Likely Oncogenic,Loss-of-function,1,ENST00000369096,NM_001198.3,No,Yes PRDM1,Y149D,Likely Oncogenic,Loss-of-function,1,ENST00000369096,NM_001198.3,No,Yes PRDM1,C569Y,Likely Oncogenic,Loss-of-function,1,ENST00000369096,NM_001198.3,No,Yes PREX2,E278*,Likely Oncogenic,Likely Gain-of-function,2,ENST00000288368,NM_024870.2,No,No PTPRT,A1022E,Oncogenic,Loss-of-function,1,ENST00000373198,NM_133170.3,No,Yes PTPRT,R1040L,Oncogenic,Likely Loss-of-function,1,ENST00000373198,NM_133170.3,No,Yes PTPRT,T844M,Likely Oncogenic,Loss-of-function,1,ENST00000373198,NM_133170.3,No,Yes PTPRT,D927G,Likely Oncogenic,Loss-of-function,1,ENST00000373198,NM_133170.3,No,Yes PTPRT,V995M,Likely Oncogenic,Loss-of-function,2,ENST00000373198,NM_133170.3,No,Yes RAC1,C157Y,Likely Oncogenic,Gain-of-function,1,ENST00000356142,NM_018890.3,Yes,No RAD50,L1273F,Likely Oncogenic,Loss-of-function,1,ENST00000265335,NM_005732.3,No,Yes RAD51B,S207L,Likely Oncogenic,Likely Loss-of-function,4,ENST00000487270,NM_133509.3,No,Yes RAD51D,S257delinsK,Likely Oncogenic,Inconclusive,1,ENST00000345365,NM_002878,No,Yes RB1,H483Y,Likely Oncogenic,Likely Loss-of-function,Likely Oncogenic,Likely Loss-of-function,1,ENST00000267163,NM_000321.2 RBM10,V354E,Oncogenic,Loss-of-function,2,ENST00000329236,NM_001204468.1,No,Yes ROBO1,R886H,Likely Oncogenic,Likely Loss-of-function,1,ENST00000464233,NM_002941.3,No,Yes ROBO1,T1160A,Likely Oncogenic,Likely Loss-of-function,1,ENST00000464233,NM_002941.3,No,Yes ROBO1,R77H,Likely Neutral,Likely Neutral,1,ENST00000464233,NM_002941.3,No,Yes RTEL1,M516I,Likely Oncogenic,Likely Loss-of-function,4,ENST00000508582,NM_032957.4,No,Yes RXRA,S247Y,Inconclusive,Inconclusive,1,ENST00000481739,NM_002957.4,No,No RXRA,S247F,Inconclusive,Inconclusive,1,ENST00000481739,NM_002957.4,No,No SDHB,L139H,Likely Oncogenic,Likely Loss-of-function,1,ENST00000375499,NM_003000.2,No,Yes SFRP1,N150*,Likely Oncogenic,Likely Loss-of-function,1,ENST00000220772,NM_003012.4,No,Yes SH2D1A,X129R,Likely Oncogenic,Likely Loss-of-function,1,ENST00000371139,NM_002351.4,No,Yes SMAD4,D357Y,Likely Oncogenic,Loss-of-function,1,ENST00000342988,NM_005359.5,No,Yes SMO,G497W,Likely Oncogenic,Likely Gain-of-function,,ENST00000249373,NM_005631.4,Yes,No SMO,S533N,Likely Oncogenic,Likely Gain-of-function,,ENST00000249373,NM_005631.4,Yes,No SMO,W281L,Likely Oncogenic,Likely Gain-of-function,,ENST00000249373,NM_005631.4,Yes,No SOX9,F12L,Likely Oncogenic,Loss-of-function,1,ENST00000245479,NM_000346.3,Yes,Yes SOX9,H65Y,Likely Oncogenic,Loss-of-function,1,ENST00000245479,NM_000346.3,Yes,Yes SOX9,A19V,Likely Neutral,Neutral,1,ENST00000245479,NM_000346.3,Yes,Yes STK11,D194E,Likely Oncogenic,Loss-of-function,,ENST00000326873,NM_000455.4,No,Yes STK19,D89N,Inconclusive,Inco