14 KiB
Executable File
14 KiB
Executable File
| 1 | Gene | Alteration | Oncogenic | Mutation_Effect | Citations |
|---|---|---|---|---|---|
| 2 | CDK6 | Amplification | Oncogenic | Gain-of-function | 4 |
| 3 | MCL1 | Amplification | Oncogenic | Gain-of-function | 4 |
| 4 | PDGFRA | Amplification | Oncogenic | Gain-of-function | 4 |
| 5 | SRC | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 6 | FGFR4 | Amplification | Oncogenic | Gain-of-function | 4 |
| 7 | ECSIT | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 8 | EGFR | Amplification | Oncogenic | Gain-of-function | 4 |
| 9 | HRAS | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 10 | ERCC2 | Amplification | Inconclusive | Inconclusive | 4 |
| 11 | ATP1A1 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 12 | UBR5 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 13 | PDGFRB | Amplification | Inconclusive | Inconclusive | 4 |
| 14 | MYC | Amplification | Oncogenic | Gain-of-function | 4 |
| 15 | CDK4 | Amplification | Oncogenic | Gain-of-function | 4 |
| 16 | RICTOR | Amplification | Oncogenic | Gain-of-function | 4 |
| 17 | ALK | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 18 | FGFR2 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 19 | PHF19 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 20 | RAC1 | Amplification | Likely Oncogenic | Gain-of-function | 4 |
| 21 | CARD11 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 22 | AXL | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 23 | FGFR1 | Amplification | Oncogenic | Gain-of-function | 4 |
| 24 | PIK3R2 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 25 | KAT7 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 26 | GLI1 | Amplification | Oncogenic | Gain-of-function | 4 |
| 27 | NRAS | Amplification | Inconclusive | Inconclusive | 4 |
| 28 | CXCR4 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 29 | PSMB2 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 30 | BRAF | Amplification | Oncogenic | Gain-of-function | 4 |
| 31 | FLT1 | Amplification | Inconclusive | Inconclusive | 4 |
| 32 | DNMT3B | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 33 | KDM5A | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 34 | AR | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 35 | MDM2 | Amplification | Oncogenic | Gain-of-function | 4 |
| 36 | YES1 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 37 | FOXA1 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 38 | MERTK | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 39 | MAP2K1 | Amplification | Inconclusive | Inconclusive | 4 |
| 40 | MYCL | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 41 | PPM1D | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 42 | NKX2-1 | Amplification | Oncogenic | Gain-of-function | 4 |
| 43 | MYCN | Amplification | Oncogenic | Gain-of-function | 4 |
| 44 | ERBB3 | Amplification | Oncogenic | Gain-of-function | 4 |
| 45 | ETV1 | Amplification | Oncogenic | Gain-of-function | 4 |
| 46 | SETD3 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 47 | ERBB2 | Amplification | Oncogenic | Gain-of-function | 4 |
| 48 | ROS1 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 49 | AURKA | Amplification | Oncogenic | Gain-of-function | 4 |
| 50 | NTRK1 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 51 | ACKR3 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 52 | MDM4 | Amplification | Oncogenic | Gain-of-function | 4 |
| 53 | GATA3 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 54 | BCL6 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 55 | JUN | Amplification | Oncogenic | Gain-of-function | 4 |
| 56 | RNASEH2A | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 57 | REV3L | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 58 | PAK1 | Amplification | Oncogenic | Gain-of-function | 4 |
| 59 | CCND3 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 60 | FGF4 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 61 | PIK3CB | Amplification | Likely Oncogenic | Gain-of-function | 4 |
| 62 | GAB2 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 63 | KIT | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 64 | RHOA | Amplification | Oncogenic | Gain-of-function | 4 |
| 65 | RAF1 | Amplification | Oncogenic | Gain-of-function | 4 |
| 66 | CCND1 | Amplification | Oncogenic | Gain-of-function | 4 |
| 67 | ESR1 | Amplification | Inconclusive | Inconclusive | 4 |
| 68 | BAALC | Amplification | Likely Oncogenic | Likely Gain-of-function | 3 |
| 69 | ID1 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 70 | KDR | Amplification | Oncogenic | Gain-of-function | 4 |
| 71 | PIK3CA | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 72 | MEF2B | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 73 | JAK2 | Amplification | Oncogenic | Gain-of-function | 4 |
| 74 | FGF3 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 75 | MAPK1 | Amplification | Likely Oncogenic | Gain-of-function | 4 |
| 76 | CD274 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 77 | MET | Amplification | Oncogenic | Gain-of-function | 4 |
| 78 | FUS | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 79 | FZR1 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 80 | YAP1 | Amplification | Oncogenic | Gain-of-function | 4 |
| 81 | CCNE1 | Amplification | Oncogenic | Gain-of-function | 4 |
| 82 | CRLF2 | Amplification | Oncogenic | Gain-of-function | 4 |
| 83 | NSD3 | Amplification | Inconclusive | Inconclusive | 4 |
| 84 | VEGFA | Amplification | Likely Oncogenic | Gain-of-function | 4 |
| 85 | SMO | Amplification | Inconclusive | Inconclusive | 4 |
| 86 | KRAS | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 87 | ADHFE1 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 88 | IKBKE | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 89 | RHEB | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 90 | ALOX12B | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 91 | BCL2L1 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 92 | BRD4 | Amplification | Likely Oncogenic | Gain-of-function | 4 |
| 93 | FGF19 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 94 | TOP1 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 95 | KMT2A | Amplification | Inconclusive | Inconclusive | 4 |
| 96 | RUNX1 | Amplification | Oncogenic | Gain-of-function | 4 |
| 97 | AGO2 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 98 | DDR2 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 99 | AKT1 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 100 | HMGA1 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 101 | TRIM27 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 102 | CYP19A1 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 103 | IRS2 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 104 | PAX5 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 105 | LGR5 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 106 | CDK8 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 107 | AKT2 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 108 | HMGA2 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 109 | CDK12 | Amplification | Inconclusive | Inconclusive | 4 |
| 110 | MITF | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 111 | PDCD1LG2 | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 112 | EZH2 | Amplification | Oncogenic | Gain-of-function | 4 |
| 113 | AKT3 | Amplification | Oncogenic | Gain-of-function | 4 |
| 114 | TERT | Amplification | Likely Oncogenic | Likely Gain-of-function | 4 |
| 115 | KDM5C | Overexpression | Likely Oncogenic | Likely Gain-of-function | 4 |
| 116 | AURKB | Overexpression | Likely Oncogenic | Likely Gain-of-function | 4 |
| 117 | RHOA | Overexpression | Oncogenic | Gain-of-function | 4 |
| 118 | CCNE1 | Overexpression | Oncogenic | Gain-of-function | 4 |
| 119 | EZH2 | Overexpression | Oncogenic | Gain-of-function | 4 |
| 120 | MSH2 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 121 | BBC3 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 122 | EP300 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 123 | CHTF8 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 124 | ATRIP | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 125 | BAP1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 126 | TGFBR1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 127 | MSH3 | Deletion | Likely Oncogenic | Loss-of-function | 4 |
| 128 | DAXX | Deletion | Oncogenic | Loss-of-function | 4 |
| 129 | DUSP4 | Deletion | Inconclusive | Inconclusive | 4 |
| 130 | FANCA | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 131 | ERRFI1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 132 | BRIP1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 133 | PTPRD | Deletion | Oncogenic | Loss-of-function | 4 |
| 134 | TGFBR2 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 135 | CTCF | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 136 | NF1 | Deletion | Likely Oncogenic | Loss-of-function | 4 |
| 137 | FBXW7 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 138 | RAD51B | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 139 | ATM | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 140 | MLH1 | Deletion | Likely Oncogenic | Loss-of-function | 4 |
| 141 | BTG1 | Deletion | Likely Oncogenic | Loss-of-function | 4 |
| 142 | RELN | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 143 | NOTCH1 | Deletion | Likely Oncogenic | Likely Gain-of-function | 4 |
| 144 | PIK3R1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 145 | XRCC2 | Deletion | Likely Neutral | Likely Loss-of-function | 4 |
| 146 | ERCC4 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 147 | NF2 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 148 | CIITA | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 149 | SOX17 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 150 | MSH6 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 151 | HNF1A | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 152 | BRCA2 | Deletion | Oncogenic | Loss-of-function | 4 |
| 153 | BCOR | Deletion | Oncogenic | Loss-of-function | 4 |
| 154 | ATRX | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 155 | DNMT3A | Deletion | Oncogenic | Loss-of-function | 4 |
| 156 | CDKN2B | Deletion | Oncogenic | Loss-of-function | 4 |
| 157 | PMS2 | Deletion | Oncogenic | Loss-of-function | 4 |
| 158 | PARP1 | Deletion | Likely Oncogenic | Loss-of-function | 4 |
| 159 | CDKN2C | Deletion | Oncogenic | Loss-of-function | 4 |
| 160 | RAD17 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 161 | CD58 | Deletion | Likely Oncogenic | Loss-of-function | 4 |
| 162 | EED | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 163 | TP53BP1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 164 | BRCA1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 165 | MED12 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 166 | SMARCA4 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 167 | CDKN2A | Deletion | Oncogenic | Loss-of-function | 4 |
| 168 | DNMT3B | Deletion | Likely Oncogenic | Loss-of-function | 4 |
| 169 | NPM1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 170 | SOX9 | Deletion | Oncogenic | Loss-of-function | 4 |
| 171 | APC | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 172 | BCL2L11 | Deletion | Oncogenic | Likely Loss-of-function | 4 |
| 173 | CIC | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 174 | SHQ1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 175 | RBM10 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 176 | AXIN1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 177 | FOXA1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 178 | PBRM1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 179 | EPHA3 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 180 | VHL | Deletion | Oncogenic | Likely Loss-of-function | 4 |
| 181 | BCL10 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 182 | KEAP1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 183 | CDC73 | Deletion | Oncogenic | Loss-of-function | 4 |
| 184 | COP1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 185 | CASP8 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 186 | PTEN | Deletion | Oncogenic | Loss-of-function | 4 |
| 187 | SETD2 | Deletion | Oncogenic | Loss-of-function | 4 |
| 188 | MGA | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 189 | STK11 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 190 | ALDH2 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 191 | TET2 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 192 | GATA3 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 193 | TP53 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 194 | REV3L | Deletion | Inconclusive | Inconclusive | 4 |
| 195 | SDHB | Deletion | Likely Oncogenic | Loss-of-function | 4 |
| 196 | INPP4B | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 197 | LATS1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 198 | TET1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 199 | RNASEH2B | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 200 | PTPN11 | Deletion | Oncogenic | Loss-of-function | 4 |
| 201 | SMARCB1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 202 | CREBBP | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 203 | RAD21 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 204 | LATS2 | Deletion | Oncogenic | Loss-of-function | 4 |
| 205 | ASXL2 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 206 | CDKN1A | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 207 | KDM6A | Deletion | Oncogenic | Loss-of-function | 4 |
| 208 | SDHD | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 209 | ARID1A | Deletion | Likely Oncogenic | Loss-of-function | 4 |
| 210 | FZR1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 211 | ASXL1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 212 | CDKN1B | Deletion | Oncogenic | Loss-of-function | 4 |
| 213 | TNFAIP3 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 214 | ARID1B | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 215 | IKZF1 | Deletion | Likely Oncogenic | Loss-of-function | 4 |
| 216 | KMT2C | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 217 | MAX | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 218 | CBL | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 219 | FH | Deletion | Likely Oncogenic | Loss-of-function | 4 |
| 220 | RB1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 221 | PPP2R2A | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 222 | MTAP | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 223 | SMAD4 | Deletion | Likely Oncogenic | Loss-of-function | 4 |
| 224 | CDH1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 225 | BARD1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 226 | TSC2 | Deletion | Oncogenic | Likely Loss-of-function | 4 |
| 227 | KMT2D | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 228 | HTATIP2 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 229 | RASA1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 230 | MEN1 | Deletion | Oncogenic | Loss-of-function | 4 |
| 231 | PAX5 | Deletion | Likely Oncogenic | Loss-of-function | 4 |
| 232 | BCL11B | Deletion | Likely Oncogenic | Loss-of-function | 4 |
| 233 | B2M | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 234 | SMAD3 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 235 | INTS6 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 236 | CDK12 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 237 | TSC1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 238 | BIRC3 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 239 | RAD50 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 240 | FAT1 | Deletion | Oncogenic | Loss-of-function | 4 |
| 241 | SMAD2 | Deletion | Likely Oncogenic | Loss-of-function | 4 |
| 242 | ANKRD11 | Deletion | Likely Oncogenic | Loss-of-function | 4 |
| 243 | DICER1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 244 | SETD3 | Overexpression | Likely Oncogenic | Likely Gain-of-function | 1 |
| 245 | CRLF2 | Overexpression | Oncogenic | Gain-of-function | 10 |
| 246 | FLT3 | Amplification | Likely Oncogenic | Gain-of-function | 2 |
| 247 | PRDM1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 4 |
| 248 | TLE1 | Deletion | Likely Oncogenic | Likely Loss-of-function | 2 |
| 249 | TLE4 | Deletion | Likely Oncogenic | Likely Loss-of-function | 2 |