#!/usr/bin/perl
# use strict;
use warnings;
die "usage:perl $0 input output project\n" unless @ARGV == 3;

open IN, "$ARGV[0]";
open OUT, ">$ARGV[1]";
my $project = $ARGV[2];

# my $public_path = defined $ENV{'PUBLIC'} ? $ENV{'PUBLIC'} : "/dataseq/jmdna/codes/public/";
my $database_path = defined $ENV{'DATABASE'} ? $ENV{'DATABASE'} : "/dataseq/jmdna/codes/reportbase";

print "Cnv过滤使用database路径：$database_path\n";

my $cnv = info();
my @cnv_list = @$cnv;

my $head = <IN>;
chomp $head;
my @head = split("\t", $head);
print OUT join("\t", (@head[0 .. 4], "ref_gene", "copy", @head[5 .. 9])), "\n";

while (<IN>) {
    chomp;
    my @line = split(/\t/, $_);
    my $cn = sprintf("%.1f", 2 ** (1 + $line[4]));
    my @gene_list = split(/,/, $line[3]);
    my %uniq;
    foreach my $element (@gene_list) {
        if (grep {$_ eq $element} @cnv_list) {
            $uniq{$element}++;
            next if $uniq{$element} > 1;
            if (($cn <= 1 or $cn >= 3.5)) {
                print OUT join("\t", (@line[0 .. 4], $element, $cn, @line[5 .. 9])), "\n";
            }
        }
    }

}

sub info {
    open INFO, "$database_path/info.csv";
    # 读取并解析表头
    my $header = <INFO>;
    chomp($header);
    my @column_names = split(',', $header);
    my (@cnvs);
    while (<INFO>) {
        chomp;
        my @line = split(/,/, $_);
        # 将数据与表头对应
        my %record;
        @record{@column_names} = @line;
        if ($record{'project'} eq $project) {
            if ($record{'cnv'} ne "NA") {
                @cnvs = split(/\//, $record{'cnv'});
            }
        }
    }
    return \@cnvs
}